The dynamics of item and context memory in the medial temporal lobe

内侧颞叶项目记忆和情境记忆的动态变化

• 批准号: 8305298
• 负责人: RACHEL A DIANA
• 金额: $ 24.9万
• 依托单位: VIRGINIA POLYTECHNIC INST AND ST UNIV
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-20 至 2014-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8305298
• 关键词: Affect; Alzheimer' s Disease; Binding; Cognitive; Disease; Episodic memory; Event; Foundations; Hippocampus (Brain); Impairment; Instruction; Medial; Memory; Mental Depression; Modeling; Nature; Neurologic; Neurosciences; Patients; Process; Psyche structure; Psychology; Quality of life; Research; Retrieval; Role; Schizophrenia; Semantics; Specific qualifier value; Temporal Lobe; Testing; Time; base; memory process; novel diagnostics; novel therapeutic intervention; relating to nervous system; stem

The central feature of episodic memory is that each item to be remembered is associated with a specific context¿a time, place, and circumstance. According to the BIC model of MTL function (Diana, Ranganath, & Yonelinas, 2007), three regions in the medial temporal lobes (MTL)¿the perirhinal cortex (PRc), parahippocampal cortex (PHc), and the hippocampus¿make qualitatively different contributions to the encoding of item information, context information, and the binding of items to episodic context, respectively. Alternative MTL models exist, however the BIC model is unique in its focus on differentiating the roles of the PRc and PHc. PHc function is the least well understood of the MTL subregions. The BIC model makes predictions both for the role of PHc in memory and the cognitive relationships between item and context information that can affect memory. This project will test the BIC model's predictions about the cognitive and neural bases of episodic memory. Specific Aims: 1) To examine the dynamics of episodic information, in particular how cognitive representations are changed as a result of unitization of item and context information. 2) To test the neural hypothesis that PHc and PRc activations are differentially involved in retrieval of context representations and item representations, respectively. 3) To identify the nature of context information represented in the PHc, testing the neural hypothesis that PHc encodes the internal, mental context of an event.

情景记忆的核心特征是每个要记住的项目都与特定的内容相关联。 语境根据 MTL 函数的 BIC 模型（Diana、Ranganath、 & Yonelinas, 2007），内侧颞叶 (MTL) 的三个区域¿鼻周皮层（PRc）， 海马旁皮质 (PHc) 和海马¿做出不同质的贡献 分别对项目信息、上下文信息以及项目与情景上下文的绑定进行编码。 存在替代的 MTL 模型，但 BIC 模型的独特之处在于它专注于区分不同的角色 PRc 和 PHc 功能是 BIC 模型中最不为人所知的。 预测 PHc 在记忆中的作用以及项目和上下文之间的认知关系 该项目将测试 BIC 模型对认知和记忆的预测。 情景记忆的神经基础 具体目标： 1）检查情景信息的动态。 特别是认知表征如何因项目和上下文的统一而改变 2) 检验 PHc 和 PRc 激活差异参与的神经假设。 3) 识别性质 PHc 中表示的上下文信息，测试 PHc 编码内部的神经假设， 事件的心理背景。