The dynamics of item and context memory in the medial temporal lobe

内侧颞叶项目记忆和情境记忆的动态变化

• 批准号: 8305298
• 负责人: RACHEL A DIANA
• 金额: $ 24.9万
• 依托单位: VIRGINIA POLYTECHNIC INST AND ST UNIV
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-20 至 2014-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8305298
• 关键词: Affect; Alzheimer' s Disease; Binding; Cognitive; Disease; Episodic memory; Event; Foundations; Hippocampus (Brain); Impairment; Instruction; Medial; Memory; Mental Depression; Modeling; Nature; Neurologic; Neurosciences; Patients; Process; Psyche structure; Psychology; Quality of life; Research; Retrieval; Role; Schizophrenia; Semantics; Specific qualifier value; Temporal Lobe; Testing; Time; base; memory process; novel diagnostics; novel therapeutic intervention; relating to nervous system; stem

The central feature of episodic memory is that each item to be remembered is associated with a specific context¿a time, place, and circumstance. According to the BIC model of MTL function (Diana, Ranganath, & Yonelinas, 2007), three regions in the medial temporal lobes (MTL)¿the perirhinal cortex (PRc), parahippocampal cortex (PHc), and the hippocampus¿make qualitatively different contributions to the encoding of item information, context information, and the binding of items to episodic context, respectively. Alternative MTL models exist, however the BIC model is unique in its focus on differentiating the roles of the PRc and PHc. PHc function is the least well understood of the MTL subregions. The BIC model makes predictions both for the role of PHc in memory and the cognitive relationships between item and context information that can affect memory. This project will test the BIC model's predictions about the cognitive and neural bases of episodic memory. Specific Aims: 1) To examine the dynamics of episodic information, in particular how cognitive representations are changed as a result of unitization of item and context information. 2) To test the neural hypothesis that PHc and PRc activations are differentially involved in retrieval of context representations and item representations, respectively. 3) To identify the nature of context information represented in the PHc, testing the neural hypothesis that PHc encodes the internal, mental context of an event.

情节内存的主要特征是，要记住的每个项目都与特定 上下文»时间，地点和环境。根据MTL功能的BIC模型（Diana，Ranganath， ＆Yonelinas，2007年），内侧临时爱情（MTL）的三个地区»周围皮层（PRC）， Parahampocampal Cortex（PHC）和海马术在质量上对 分别编码项目信息，上下文信息和项目与情节上下文的结合。 存在替代的MTL模型，但是BIC模型在重点是区分角色方面是独一无二的 中国和PHC。 PHC功能是MTL子区域最不理解的。 BIC模型使 预测PHC在记忆中的作用以及项目和上下文之间的认知关系 可能影响内存的信息。该项目将测试BIC模型对认知和 情节记忆的神经基础。具体目的：1）检查情节信息的动态， 特别是由于项目和上下文的单位化而改变认知表示 信息。 2）检验神经假说，即PHC和PRC激活与 分别检索上下文表示和项目表示。 3）确定的本质 PHC中表示的上下文信息，测试了PHC编码内部的神经假设 事件的心理背景。