The Dynamics of Item and Context Memory in the Medial Temporal Lobe

内侧颞叶项目记忆和情境记忆的动态

• 批准号: 7659798
• 负责人: RACHEL A DIANA
• 金额: $ 8.51万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-20 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7659798
• 关键词: Affect; Alzheimer' s Disease; Behavioral; Binding; Cognitive; Disease; Episodic memory; Event; Foundations; Functional Magnetic Resonance Imaging; Goals; Hippocampus (Brain); Human; Impairment; Medial; Memory; Methodology; Methods; Modeling; Nature; Neurologic; Neurosciences; Patients; Positioning Attribute; Process; Psychology; Quality of life; Research; Research Personnel; Retrieval; Role; Schizophrenia; Semantics; Specific qualifier value; Temporal Lobe; Testing; Therapeutic; Time; Training; Universities; base; cognitive neuroscience; depression; memory process; novel diagnostics; relating to nervous system; stem

DESCRIPTION (provided by applicant): A central feature of episodic memories is that each item to be remembered is associated with a specific context-a time, place, and situation. According to the BIC model of MTL function (Diana, Ranganath, & Yonelinas, 2007), three regions in the medial temporal lobes (MTL)-the perirhinal cortex (PRc), parahippocampal cortex (PHc), and the hippocampus-make qualitatively different contributions to the encoding of item information, context information, and the binding of items to episodic context, respectively. Alternative MTL models exist, however the BIC model is unique in its focus on differentiating the roles of the PRc and PHc. PHc function is the least well understood of the MTL subregions. The BIC model makes predictions both for the role of PHc in memory and the cognitive relationships between item and context information that can affect memory. This application will test the BIC model's predictions about the cognitive and neural bases of episodic memory. Specific Aims: 1)To examine the dynamics of episodic information, testing the cognitive hypothesis that item and context information are typically represented as separate pieces of information but can be unitized under specific encoding conditions. We will use ERP and behavioral methods to explore these cognitive questions regarding item and context information in memory. 2) To test the neural hypothesis that PHc and PRc activations are dissociable and are differentially involved in encoding of context representations and item representations, respectively. We will use fMRI methodology to dissociate the functions of PHc and PRc in memory. 3) To identify the nature of context information represented in the PHc, testing the neural hypothesis that PHc encodes spatial, semantic, and temporal context information. We will use fMRI methodology to define the nature of memory representations in PHc. The proposed projects will provide training in ERP, fMRI, and patient methodologies, enabling me to pursue my goal of becoming an independent investigator of the cognitive neuroscience of human memory. I intend to complete my training through two additional years of postdoctoral research and then obtain a position at a major research university to continue my research.

描述（由申请人提供）：情节记忆的主要特征是，要记住的每个项目都与特定的上下文，时间，地点和情况相关联。 According to the BIC model of MTL function (Diana, Ranganath, & Yonelinas, 2007), three regions in the medial temporal lobes (MTL)-the perirhinal cortex (PRc), parahippocampal cortex (PHc), and the hippocampus-make qualitatively different contributions to the encoding of item information, context information, and the binding of items to episodic context, 分别。存在替代的MTL模型，但是BIC模型在区分PRC和PHC的角色方面是独一无二的。 PHC功能是MTL子区域最不理解的。 BIC模型既可以预测PHC在记忆中的作用以及可能影响内存的项目和上下文信息之间的认知关系。该应用程序将测试BIC模型对情节记忆的认知和神经碱基的预测。具体目的：1）检查情节信息的动力学，测试认知假设，即项目和上下文信息通常表示为单独的信息，但可以在特定的编码条件下进行单位化。我们将使用ERP和行为方法来探讨有关记忆中有关项目和上下文信息的这些认知问题。 2）测试神经假说，即PHC和PRC激活是可分离的，并且分别参与了上下文表示和项目表示的编码。我们将使用fMRI方法来解离PHC和PRC在记忆中的功能。 3）确定PHC中代表的上下文信息的性质，测试了PHC编码空间，语义和时间上下文信息的神经假设。我们将使用fMRI方法来定义PHC中内存表示的性质。拟议的项目将在ERP，fMRI和患者方法论中提供培训，使我能够追求成为人类记忆认知神经科学的独立研究者的目标。我打算通过另外两年的博士后研究来完成我的培训，然后在一所大型研究大学的职位上继续我的研究。