The Dynamics of Item and Context Memory in the Medial Temporal Lobe

内侧颞叶项目记忆和情境记忆的动态

• 批准号: 7659798
• 负责人: RACHEL A DIANA
• 金额: $ 8.51万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-20 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7659798
• 关键词: Affect; Alzheimer' s Disease; Behavioral; Binding; Cognitive; Disease; Episodic memory; Event; Foundations; Functional Magnetic Resonance Imaging; Goals; Hippocampus (Brain); Human; Impairment; Medial; Memory; Methodology; Methods; Modeling; Nature; Neurologic; Neurosciences; Patients; Positioning Attribute; Process; Psychology; Quality of life; Research; Research Personnel; Retrieval; Role; Schizophrenia; Semantics; Specific qualifier value; Temporal Lobe; Testing; Therapeutic; Time; Training; Universities; base; cognitive neuroscience; depression; memory process; novel diagnostics; relating to nervous system; stem

DESCRIPTION (provided by applicant): A central feature of episodic memories is that each item to be remembered is associated with a specific context-a time, place, and situation. According to the BIC model of MTL function (Diana, Ranganath, & Yonelinas, 2007), three regions in the medial temporal lobes (MTL)-the perirhinal cortex (PRc), parahippocampal cortex (PHc), and the hippocampus-make qualitatively different contributions to the encoding of item information, context information, and the binding of items to episodic context, respectively. Alternative MTL models exist, however the BIC model is unique in its focus on differentiating the roles of the PRc and PHc. PHc function is the least well understood of the MTL subregions. The BIC model makes predictions both for the role of PHc in memory and the cognitive relationships between item and context information that can affect memory. This application will test the BIC model's predictions about the cognitive and neural bases of episodic memory. Specific Aims: 1)To examine the dynamics of episodic information, testing the cognitive hypothesis that item and context information are typically represented as separate pieces of information but can be unitized under specific encoding conditions. We will use ERP and behavioral methods to explore these cognitive questions regarding item and context information in memory. 2) To test the neural hypothesis that PHc and PRc activations are dissociable and are differentially involved in encoding of context representations and item representations, respectively. We will use fMRI methodology to dissociate the functions of PHc and PRc in memory. 3) To identify the nature of context information represented in the PHc, testing the neural hypothesis that PHc encodes spatial, semantic, and temporal context information. We will use fMRI methodology to define the nature of memory representations in PHc. The proposed projects will provide training in ERP, fMRI, and patient methodologies, enabling me to pursue my goal of becoming an independent investigator of the cognitive neuroscience of human memory. I intend to complete my training through two additional years of postdoctoral research and then obtain a position at a major research university to continue my research.

描述（由申请人提供）：情景记忆的一个核心特征是要记住的每个项目都与特定的上下文（时间、地点和情况）相关联。根据 MTL 功能的 BIC 模型（Diana、Ranganath 和 Yonelinas，2007），内侧颞叶（MTL）中的三个区域——鼻周皮层（PRc）、海马旁皮层（PHc）和海马——使得质上不同分别对项目信息、上下文信息的编码以及项目与情景上下文的绑定做出贡献。存在替代的 MTL 模型，但 BIC 模型的独特之处在于它侧重于区分 PRc 和 PHc 的角色。 PHc 功能是 MTL 亚区中最不为人所知的。 BIC 模型对 PHc 在记忆中的作用以及可能影响记忆的项目和上下文信息之间的认知关系进行预测。该应用程序将测试 BIC 模型对情景记忆的认知和神经基础的预测。具体目标： 1）检查情景信息的动态，测试认知假设，即项目和上下文信息通常表示为单独的信息片段，但可以在特定的编码条件下统一。我们将使用 ERP 和行为方法来探索这些关于记忆中的项目和上下文信息的认知问题。 2）测试PHc和PRc激活是可分离的并且分别不同地参与上下文表示和项目表示的编码的神经假设。我们将使用功能磁共振成像方法来分离 PHc 和 PRc 在记忆中的功能。 3) 识别 PHc 中表示的上下文信息的性质，测试 PHc 编码空间、语义和时间上下文信息的神经假设。我们将使用功能磁共振成像方法来定义 PHc 中记忆表征的本质。拟议的项目将提供 ERP、功能磁共振成像和患者方法方面的培训，使我能够实现成为人类记忆认知神经科学独立研究者的目标。我打算通过另外两年的博士后研究来完成我的培训，然后在一所主要研究型大学获得一个职位来继续我的研究。