Confirmation of Cancer and Cause of Death

癌症和死因的确认

• 批准号: 8376899
• 负责人: Meir Stampfer
• 金额: $ 32.62万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8376899
• 关键词: Authorization documentation; Cancer Etiology; Cause of Death; Cessation of life; Characteristics; Colorectal Cancer; Computer software; Custom; Data; Data Files; Death Records; Diagnosis; Diet; Disease; Epidemiology; Family; Funding; Histopathology; Hormonal; Incidence; Institution; Learning; Letters; Mails; Malignant Neoplasms; Malignant neoplasm of ovary; Medical; Medical Records; Nonrespondent; Nurses' Health Study; Participant; Physicians; Protocols documentation; Questionnaires; Records; Report (document); Reporting; Research; Research Personnel; Secure; Site; Software Design; Source; Staging; Telephone Interviews; Trust; Update; Woman; cancer diagnosis; cohort; follow-up; improved; indexing; malignant breast neoplasm; mortality; prevent; tumor; tumor registry

Core B is responsible for confirming all cancer reports and all deaths in the Nurses' Health Study cohort. The specific aims for this core are as follows: 1) To document and confirm reports of incident cancer as collected from the questionnaires, telephone interviews, and death records. 2) To identify all deaths among cohort participants and to ascertain the cause of death. 3) To provide standardized data files of cancer diagnoses and all deaths for epidemiologic analyses. Under the direction of Meir Stampfer, MD, DrPh, Core B obtains medical records and other relevant information to confirm cancer diagnoses and cohort deaths. The trust that has evolved over the past thirty-two years between the NHS investigators and cohort participants has led to an extremely high degree of cooperation in securing permission to review medical records, and from the families in ascertaining the details of the cause of death. Medical records are reviewed by physicians according to uniform standardized criteria to confirm the cancer diagnoses and obtain details of the histopathology, including tumor site, stage, and grade. We learn of most deaths through the questionnaire mailings and we search the National Death Index for questionnaire nonrespondents. State tumor registries are also utilized to confirm cancer diagnoses and deaths. Custom-designed computer software has been developed to track the progress from the initial report of a diagnosis or death to the final confirmation. The software also automatically generates letters to participants and medical institutions for requesting medical records and additional Information. At the end of every biennial follow-up cycle, standardized files are generated for specific cancer diagnoses and for all deaths to be used by all investigators conducting research with the NHS data.

核心B负责确认护士健康研究队列中所有癌症报告和所有死亡。 该核心的具体目的如下： 1）记录并确认从问卷，电话访谈和死亡记录中收集的事件癌症的报告。 2）确定队列参与者中的所有死亡并确定死亡原因。 3）为流行病学分析提供癌症诊断和所有死亡的标准化数据文件。 在Meir Stampfer，医学博士，DRPH，Core B的指导下，获得了医疗记录和其他相关信息，以确认癌症诊断和队列死亡。在过去的32年中，NHS调查人员和队列参与者之间发展的信任已导致在确保审查医疗记录的许可方面以及确定死亡原因细节的家人方面具有极高的合作。医生根据统一的标准化标准对病历进行了审查，以确认癌症诊断并获得组织病理学的细节，包括肿瘤部位，阶段和等级。我们通过问卷邮件了解了大多数死亡，并搜索了国家死亡指数，以获取无响应者的问卷。国家肿瘤注册机构还用于确认癌症诊断和死亡。已经开发了定制设计的计算机软件，以跟踪从诊断或死亡的初始报告到最终确认的进度。该软件还会自动生成给参与者和医疗机构的信件，以索取医疗记录和其他信息。在每个两年一次的随访周期结束时，为特定的癌症诊断生成了标准化文件，并为所有人生成 所有研究人员都使用NHS数据进行研究。