Function of 3'UTRs

3UTR 的功能

基本信息

批准号：
8197924
负责人：
Marvin P. Wickens
金额：
$ 34.2万
依托单位：
UNIVERSITY OF WISCONSIN-MADISON
依托单位国家：
美国
项目类别：
财政年份：
1994
资助国家：
美国
起止时间：
1994-04-01 至 2013-01-13
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8197924
关键词：
3&apos Untranslated Regions Binding Biochemical Bioinformatics Biological Biology Caenorhabditis elegans Cell-Free System Cells Complex Critical Pathways DNA Data Development Disease Elements Eukaryota Eukaryotic Cell Explosion Family Floods Foundations Genetic Genetic Translation Genome Goals Health Homeostasis In Vitro Indium Intervention Learning Location Malignant Neoplasms Mammalian Cell Mediating Memory Messenger RNA MicroRNAs Molecular Molecular Genetics Muscular Dystrophies Nature Outcome Poly(A) Tail Proteins RNA RNA Binding RNA Sequences Recruitment Activity Regulation Regulatory Element Repression Research Role Saccharomyces cerevisiae Small RNA Specificity Stem cells Structure System Terminator Codon Thalassemia Translations Untranslated Regions Viral Work Xenopus base combinatorial design genetic regulatory protein in vivo mRNA Decay mRNA Stability novel strategies protein complex

项目摘要

DESCRIPTION (provided by applicant): Project Summary - DNA makes RNA makes protein. The second step of that pathway - the critical function of RNA in genetic information transfer - is exquisitely regulated. mRNA activity, stability and location are controlled by factors that recognize specific RNA sequences. We focus on the PUF proteins, a widespread family of mRNA regulatory proteins that control key steps in early development and are required for establishing memory. We propose to determine how these proteins find and recognize specific mRNAs, and how they then execute that decision. PUBLIC HEALTH RELEVANCE: Project Narrative The proposed work will illuminate how a widespread family of mRNA regulatory proteins work. These proteins control stem cells and participate in the formation of memory. Understanding how they work should provide practical opportunities for intervention.

描述（由申请人提供）：项目摘要 - DNA 使 RNA 产生蛋白质。该途径的第二步——RNA 在遗传信息传递中的关键功能——受到精心调控。 mRNA 的活性、稳定性和位置由识别特定 RNA 序列的因素控制。我们重点关注 PUF 蛋白，这是一个广泛存在的 mRNA 调节蛋白家族，它控制着早期发育的关键步骤，并且是建立记忆所必需的。我们建议确定这些蛋白质如何发现和识别特定的 mRNA，以及它们如何执行该决定。公共健康相关性：项目叙述拟议的工作将阐明广泛的 mRNA 调节蛋白家族如何发挥作用。这些蛋白质控制干细胞并参与记忆的形成。了解它们的工作原理应该为干预提供实际的机会。