COBRE for Skeletal Health and Repair

COBRE 用于骨骼健康和修复

基本信息

批准号：
8337517
负责人：
QIAN CHEN
金额：
$ 219.23万
依托单位：
RHODE ISLAND HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-09-10 至 2017-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8337517
关键词：
Adult Affect American Area Arthritis Basic Science Benchmarking Biological Biology Biomedical Engineering Biotechnology Bone Growth Bone Regeneration Calcium Cartilage Cartilage Diseases Center for Translational Science Activities Centers of Research Excellence Chondrocytes Clinical Core Facility Crystal Formation Degenerative polyarthritis Discipline Disease Engineering Environment Equipment Extramural Activities Faculty Fatty acid glycerol esters Funding Generations Genes Goals Grant Harvest Health Hospitals Housing Joints Laboratories Life Mechanics Medicine Mentors Mentorship Mesenchymal Stem Cells Molecular Molecular Biology Molecular Medicine Orthopedics Pathway interactions Peer Review Pharmacology Phase Physiology Pilot Projects Prevalence Prevention Prevention strategy Principal Investigator Recruitment Activity Research Research Infrastructure Research Personnel Research Project Grants Rhode Island Scientist Side Skeletal Development Stem cells Tissue Engineering Tissues Training Programs Translational Research United States National Institutes of Health Universities Ursidae Family Vision Work aged arthropathies articular cartilage base career cost disability human FRAP1 protein interdisciplinary approach long bone medical schools meetings member molecular imaging multidisciplinary novel strategies programs public health relevance repaired role model skeletal success

项目摘要

DESCRIPTION (provided by applicant): The long-term goal of the Center of Biomedical Research Excellence (COBRE) is to develop a multidisciplinary translational research center focusing on discovering cartilage and joint health and disease mechanisms and developing repair strategy. During the Phase I of COBRE, great progress has been made in mentoring junior investigators into leaders of R01 grant funded research programs. The main objective of the Phase II COBRE is to sustain the success by recruiting more promising junior investigators into the COBRE research programs thereby further expanding and enhancing the base of skeletal research in Rhode Island Hospital and Brown University. The new research projects encompass clinical, biological, and engineering research fields. Project 1 analyzes how mechanical loading affects long bone growth during skeletal development. Project 2 examine how joint cartilage degenerates in adult joint diseases. Project 3 develops novel strategies of harvesting stem cells from fat tissues to repair bone. The investigators and mentors are selected from three departments in Rhode Island Hospital/The Alpert Medical School of Brown University (Orthopaedics, Medicine, and Molecular Pharmacology, Physiology, and Biotechnology). The junior investigators include a biologist, a bioengineer, and a clinician/scientist. The mentors also include biologists, engineers, and clinician/scientists. Eachmentor is a Principal Investigator of multiple federal grants including NIH R01. They will supervise junior investigator's research projects, serve as their role models, and mentor them to obtain federal research project grants. Our vision is, by sustaining and developing this research infrastructure, we will enable clinicians working side-by-side with basic research scientists, junior investigators with senior investigators, and biologists with bioengineers. This multidisciplinary approach is absolutely necessary to develop translational strategies for prevention and treatment of skeletal joint diseases.

描述（由申请人提供）：生物医学研究卓越中心（COBRE）的长期目标是开发一个多学科转化研究中心，重点是发现软骨，关节健康和疾病机制以及制定维修策略。在Cobre的第一阶段，在指导初级调查人员为R01赠款资助的研究计划的领导者方面取得了巨大进展。 II阶段索布尔的主要目的是通过招募更多有前途的初级研究人员参加毛cre研究计划，从而进一步扩大和增强罗德岛医院和布朗大学的骨骼研究基础，以维持成功。新的研究项目包括临床，生物学和工程研究领域。项目1分析机械负荷如何影响骨骼发育过程中的长骨生长。项目2检查关节软骨如何在成人关节疾病中退化。项目3开发了从脂肪组织收集干细胞到修复骨骼的新型策略。研究人员和导师是从罗德岛医院/布朗大学阿尔珀特医学院（骨科，医学和分子药理学，生理学和生物技术）中选出的。初级研究人员包括生物学家，生物工程师和临床医生/科学家。指导者还包括生物学家，工程师和临床医生/科学家。每个人是包括NIH R01在内的多项联邦赠款的首席调查员。他们将监督初级调查员的研究项目，并作为其榜样，并指导他们获得联邦研究项目赠款。我们的愿景是通过维持和发展这项研究基础设施，我们将使临床医生能够与基础研究科学家，高级研究人员的初级研究人员以及生物工程师的生物学家并肩工作。这种多学科方法对于制定预防和治疗骨骼关节疾病的翻译策略是绝对必要的。