COBRE for Skeletal Health & Repair

COBRE 促进骨骼健康

• 批准号: 10263335
• 负责人: QIAN CHEN
• 金额: $ 114.27万
• 依托单位: RHODE ISLAND HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10263335
• 关键词: American; Animals; Basic Science; Benchmarking; Biomechanics; Biomedical Engineering; Caliber; Cartilage; Cartilage Diseases; Cells; Center for Translational Science Activities; Centers of Research Excellence; Collaborations; Core Facility; Degenerative polyarthritis; Development; Diagnostic; Discipline; Engineering; Environment; Equipment; Faculty; Funding; Future; Generations; Goals; Grant; Health; Hospitals; Image; Infrastructure; International; Joints; Laboratories; Leadership; Mentors; Molecular; Molecular Biology; Motion; Musculoskeletal; Musculoskeletal Diseases; Nature; Organ; Peer Review; Performance; Phase; Pilot Projects; Prevention; Prevention strategy; Principal Investigator; Publishing; Research; Research Infrastructure; Research Peer Review; Research Personnel; Research Project Grants; Resources; Rhode Island; Science; Scientist; Services; Side; Testing; Therapeutic; Tissues; Training; Training Programs; Translational Research; United States National Institutes of Health; Universities; Vision; arthropathies; bench to bedside; disability; interdisciplinary approach; laboratory facility; multidisciplinary; nanomaterials; nanomedicine; novel; programs; recruit; repaired; skeletal; success; translational approach; treatment strategy

Overall 7. Project Summary/Abstract The long-term goal of the Center of Biomedical Research Excellence (COBRE) for Skeletal Health and Repair is to develop a multi-disciplinary translational research center focusing on discovering mechanisms of cartilage joint diseases and developing prevention and treatment strategies. Since the start of the COBRE eight years ago, seven full project investigators have received R01 or R01-equivalent federal grants and “graduated” from the COBRE training program, and published more than 240 peer-reviewed articles including landmark discoveries in Nature, Molecular Cell, and PNAS. All twenty target junior investigators have received exramural funding as Principal Investigator, and new state-of-the-art laboratories and core facilities have been built in bioengineering, imaging, molecular biology and nanomedicine. The main objective of the Phase III COBRE is to strengthen and transition the COBRE research infrastructure into a competitive, independent, and self- sustaining academic center of excellence-Brown Center of Musculoskeletal and Motion Sciences (BCMMS) in five years. To achieve this main objective, four specific aims are proposed as follows. Aim 1, Administrative Core provides strong leadership in translational research, evaluates the performance of technical Core Resources and Facilities, guides mentoring efforts in the Pilot Projects Program, and implements the COBRE transitioning plan; Aim 2, Bioengineering Core enhances an interactive research environment and provides the unique resources of biomechanical testing at the cell, tissue, and organ levels; Aim 3, Imaging, Molecular Biology, and Nanomedicine Core enhances translational research from bench to bedside, provides critical expertise and equipment in small animal live imaging analysis, and facilitates development of novel nanomaterial delivery vehicles for diagnostics and therapeutics; and Aim 4, Pilot Projects Program mentors a new generation of researchers in multiple disciplines of musculoskeletal research including clinicians, biologists, and engineers, facilitates research collaborations, and sustains the strong research environment developed in the first two phases of COBRE. Our vision is, by sustaining and transitioning the established high- caliber research infrastructure, we will enable clinicians working side-by-side with basic research scientists, junior investigators with senior investigators, and biologists with bioengineers for a long term into the future.

全面的 7。项目摘要/摘要 生物医学研究中心卓越中心（COBRE）的长期目标是骨骼健康和维修 是开发一个多学科翻译研究中心，重点是发现软骨的机制 关节疾病并制定预防和治疗策略。自从索布尔开始八年以来 以前，七名完整的项目调查人员已获得R01或R01等效赠款，并从 《毛cre培训计划》，并发表了240多个同行评审的文章，包括地标 自然界，分子细胞和PNA中的发现。所有二十个目标初级调查人员都收到了弹药 作为首席调查员的资金以及新的最先进的实验室和核心设施的资金已建成 生物工程，成像，分子生物学和纳米医学。第三阶段的主要目的是 为了加强和过渡毛cre研究基础设施为竞争，独立和自我 维持肌肉骨骼和运动科学（BCMMS）的卓越学术中心 五年。为了实现这一主要目标，提出了四个具体目标，如下所示。目标1，行政 核心在转化研究中提供了强大的领导才能，评估技术核心的性能 资源和设施，指导飞行员项目计划中的心理努力，并实现毛茸茸 过渡计划；目标2，生物工程核心增强了交互式研究环境，并提供了 在细胞，组织和器官水平上生物力学测试的独特资源；目标3，成像，分子 生物学和纳米医学核心增强了从长凳到床边的转化研究，提供了关键 小动物实时成像分析中的专业知识和设备，并促进了新颖的发展 用于诊断和治疗的纳米材料递送车； AIM 4，飞行员项目计划指导 新一代研究人员在包括临床医生在内的肌肉骨骼研究的多个学科中 生物学家和工程师促进研究合作，并维持强大的研究环境 在毛绒的前两个阶段中开发。我们的愿景是维持和过渡既定的高级 口径研究基础设施，我们将使临床医生能够与基础研究科学家并肩工作， 高级研究人员和生物工程师的初级调查员长期以来一直在未来。