Facility Core B--Pulmonary Toxicology

设施核心B——肺毒理学

• 批准号: 7239987
• 负责人: Peter S Thorne
• 金额: $ 23.63万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7239987
• 关键词: Acute; Aerosols; Airway Resistance; Allergens; Animal Model; Animals; Area; Asthma; Behavior; Biological Assay; Biological Markers; Biology; Breathing; Consultations; Core Facility; Development; Devices; Disease; Dose; End Point; Endotoxins; Environmental Health; Evaluation; Exposure to; Funding; Gases; Generations; Goals; Host resistance; Inhalation Exposure; Inhalation Therapy; Inhalation Toxicology; Knockout Mice; Lung; Lung diseases; Maintenance; Measurement; Methodology; Nose; Performance; Physiological; Predisposition; Prevention; Productivity; Property; Research; Research Personnel; Rodent; Sampling; Science; Scientist; Services; Structure of parenchyma of lung; System; Systems Analysis; Testing; Toxicology; Transgenic Organisms; improved; innovation; interest; methacholine; nanoparticulate; novel; post-doctoral training; pre-doctoral; resistance factors; response; toxicant; vapor

The goal of the Pulmonary Toxicology Facility Core (PTF, formerly the Inhalation Toxicology Facility) is to provide the facilities and expertise for EHSRC investigators to enhance the productivity and quality of their pulmonary toxicology research and to assist them in exploring new investigative areas in asthma, pulmonary biology, inhalation toxicology, or aerosol science. In addition, investigators from NIEHS-funded Environmental Health Centers are supported with expertise and assays for evaluation of exposures to asthma triggers. This facility provides assistance for testing hypotheses regarding the: ¿ Pulmonary biology of asthma and other environmental lung diseases; ¿ Development and prevention of environmental lung disease; ¿ Physicochemical properties and behavior of endotoxin, allergens, bioaerosols, and other airborne toxicants; and ¿ Performance of sampling devices commonly used by aerosol scientists and hygienists for environmental assessment.

肺毒理学设施核心（PTF，以前的吸入毒理学设施）的目标是 为 EHSRC 调查人员提供设施和专业知识，以提高其工作效率和质量 肺毒理学研究并协助他们探索哮喘的新研究领域， 此外，NIEHS 资助的研究人员还从事肺部生物学、吸入毒理学或气溶胶科学的研究。 环境卫生中心得到专业知识和分析的支持，用于评估接触 该设施为测试有关以下方面的假设提供帮助： ¿哮喘和其他环境性肺部疾病的肺部生物学； ¿环境性肺病的发生和预防； ¿内毒素、过敏原、生物气溶胶和其他空气传播物质的理化特性和行为 有毒物质；和 ¿气溶胶科学家和卫生学家常用的采样装置的性能 环境评估。