Studying Colorectal Cancer Effectiveness of Screening Strategies (SuCCESS)

研究结直肠癌筛查策略的有效性 (SuCCESS)

基本信息

批准号：
8335410
负责人：
CAROLYN M RUTTER
金额：
$ 84.63万
依托单位：
KAISER FOUNDATION HEALTH PLAN OF WASHINGTON
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-09-20 至 2016-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8335410
关键词：
Address Advisory Committees Behavior Benefits and Risks Cancer Etiology Cessation of life Colorectal Colorectal Cancer Commit Complex Data Data Collection Data Sources Diagnostic Procedure Disease Documentation Effectiveness Equilibrium Evaluation Foundations Goals Health Health Personnel Individual Information Systems Instruction Integrated Delivery of Health Care Knowledge Link Medical Meta-Analysis Methods Modality Modeling Morbidity - disease rate Outcome Pathologic Pathology Patient Preferences Patients Pattern Policies Policy Maker Preventive Process Provider Public Health Recommendation Recording of previous events Regimen Relative (related person)Research Research Activity Research Institute Research Personnel Risk Risk Factors Screening for cancer Screening procedure Second Primary Cancers Services Source Staging Subgroup System Testing United States Washington Work adenoma base cancer diagnosis cancer therapy clinical practice cohort colorectal cancer screening comparative effectiveness compare effectiveness cost electronic data evidence base improved information gathering member models and simulation mortality multidisciplinary prevent prospective

项目摘要

PROJECT SUMIVIARY (See Instructions): The overarching goal of our proposed project, SuCCESS: Studying Colorectal Cancer: Effectiveness of Screening Strategies, is to develop evidence to inform personalized screening recommendations that maintain most or all of the benefits of intensive screening, minimize risks and costs, and respect patient preferences. Based within Group Health Research Institute (GHRI), the SuCCESS project will draw on a wide array of rich electronic data sources available at Group Health (GH), an integrated health care delivery system in Washington State, to gather information about risk factors, screening patterns, diagnostic procedures, pathology, treatment, and cancer outcomes among GH enrollees. The SuCCESS project will use GH data to describe colorectal cancer (CRC) screening as practiced, including behaviors and effectiveness, and will build on this information to examine the potential for personalized screening regimens. We propose 3 linked projects related to this overall goal. Project 1, "Comparative effectiveness of colorectal cancer screening as practiced," will provide information about how screening is practiced, about patient decisions regarding screening modalities, and about the comparative effectiveness of different screening regimens as practiced. Project 2: "Personalizing colorectal cancer screening and surveillance," will focus on identifying effective personalized screening regimens based on screening history and other individual risk factors. Project 3, "Modeling long-term comparative effectiveness of colorectal screening," will use disease simulation models to predict the long-term effectiveness of different screening and surveillance regimens on botii overall and CRC mortality based on results from Project 1 and Project 2, and will develop a cohort model for CRC that will be freely distributed. Our proposed body of research will provide an important foundation for personalized clorectal cancer screening, and will produce results that are useful to a multidisciplinary audience, including clinicians, patients, policy makers, researchers, and professional medical organizations.

项目Sumiviary（请参阅说明）：我们提议的项目的总体目标，成功：研究结直肠癌：筛查策略的有效性，是为了提供证据，以告知个性化筛查建议，以维持密集筛查的大部分或全部好处，最大程度地减少风险和成本，并尊重患者的偏好。在集团健康研究所（GHRI）中，成功项目将利用华盛顿州的综合医疗保健提供系统集团健康（GH）提供了各种各样的丰富电子数据源，以收集有关GH参与者中的风险因素，筛查模式，诊断程序，病理，治疗和癌症结果的信息。成功项目将使用GH数据来描述练习的结直肠癌（CRC）筛查，包括行为和有效性，并将基于此信息来研究个性化筛查方案的潜力。我们提出了3个与此总体目标有关的链接项目。项目1，“实践的结直肠癌筛查的比较有效性”将提供有关筛查的筛查，有关筛查方式的患者决策以及有关不同筛查的比较有效性的信息实践方案。项目2：“个性化结直肠癌筛查和监视”，将重点放在基于筛查病史和其他个人危险因素的有效个性化筛查方案上。项目3，“对结直肠筛查的长期比较有效性进行建模”，将使用疾病模拟模型根据项目1和Project 2的结果来预测BOTII整体和CRC死亡率的不同筛查和监视方案的长期有效性，并将开发CRC的同类模型，以自由分配CRC。我们拟议的研究机构将为个性化的克利直肠癌筛查提供重要的基础，并将产生对多学科受众有用的结果，包括临床医生，患者，政策制定者，研究人员和专业的医疗组织。