CORES

核心

• 批准号: 8555319
• 负责人: CAROLYN M RUTTER
• 金额: $ 17.59万
• 依托单位: KAISER FOUNDATION HEALTH PLAN OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-20 至 2016-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8555319
• 关键词: Colorectal Cancer; Effectiveness; Screening procedure

PROJECT SUMIVIARY (See Instructions) The overarching goal of our proposed project, SuCCESS: Studying Colorectal Cancer: Effectiveness of Screening Strategies, is to develop evidence to inform personalized screening recommendations that maintain most or all of the benefits of intensive screening, minimize risks and costs, and respect patient preferences. Based within Group Health Research Institute (GHRI), the SuCCESS project will draw on wide array of rich electronic data sources available at Group Health (GH), an integrated health care delivery system in Washington State, to gather information about risk factors, screening patterns, diagnostic procedures, pathology, treatment, and cancer outcomes among GH enrollees. The SuCCESS project will use GH data to describe colorectal cancer (CRC) screening as practiced, including behaviors and effectiveness, and will build on this information to examine the potential for personalized screening regimens. We propose 3 linked projects related to this overall goal. Project 1, "Comparative effectiveness of colorectal cancer screening as practiced," will provide information about how screening is practiced, about patient decisions regarding screening modalities, and about the comparative effectiveness of different screenin regimens as practiced. Project 2: "Personalizing colorectal cancer screening and surveillance," will focus on identifying effective personalized screening regimens based on screening history and other individual risk factors. Project 3, "Modeling long-term comparative effectiveness of colorectal screening," will use disease simulation models to predict the long-term effectiveness of different screening and surveillance regimens on botii overall and CRC mortality based on results from Project 1 and Project 2, and will develop a cohort model for CRC that will be freely distributed. Our proposed body of research will provide an important foundation for personalized clorectal cancer screening, and will produce results that are useful to a multidisciplinary audience, including clinicians, patients, policy makers, researchers, and professional medical organizations

项目律师事务（请参阅说明）我们提出的项目的总体目标，成功：研究结直肠癌：筛查策略的有效性，是为了提供证据，以告知个性化筛查建议，以维持密集筛查的大部分或全部好处，最小化风险和成本的最小化，并尊重患者偏好。该成功项目位于集团健康研究所（GHRI）内，将利用多种在华盛顿州的综合卫生保健提供系统可提供的丰富的电子数据来源，以收集有关风险因素，筛查模式，诊断程序，病理，病理，病理，治疗和GH GH参与者的信息。成功项目将使用GH数据来描述练习的结直肠癌（CRC）筛查，包括行为和有效性，并将基于此信息来研究个性化筛查方案的潜力。我们提出了3个与此总体目标有关的链接项目。项目1，“实践的结直肠癌筛查的比较有效性”将提供有关筛查的筛查方式，有关筛查方式的患者决策的信息，以及有关实践的不同筛查方案的比较有效性。项目2：“个性化结直肠癌筛查和监视”，将重点放在基于筛查病史和其他个人危险因素的有效个性化筛查方案上。项目3，“对结直肠筛查的长期比较有效性进行建模”，将使用疾病模拟模型根据项目1和Project 2的结果来预测BOTII整体和CRC死亡率的不同筛查和监视方案的长期有效性，并将开发CRC的同类模型，以自由分配CRC。我们拟议的研究机构将为个性化的克利直肠癌筛查提供重要的基础，并将产生对多学科受众有用的结果，包括临床医生，患者，政策制定者，研究人员和专业的医疗组织