Development Research Plan

发展研究计划

• 批准号: 8234057
• 负责人: ASHLEE V. MOSES
• 金额: $ 62.39万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-03-01 至 2014-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8234057
• 关键词: Address; Administrator; Biological; Bioterrorism; Categories; Communication; Complement; Defect; Development; Diagnostic; Electronics; Emerging Communicable Diseases; Emerging Technologies; Funding; Genetic; Goals; Growth; Immune system; Lead; Measures; Mission; National Institute of Allergy and Infectious Disease; Natural Immunity; Oregon; Pacific Northwest; Pilot Projects; Policies; Research; Research Personnel; Research Project Grants; Risk; Scientist; System; Systems Biology; Talents; Technology; Translational Research; Washington; adaptive immunity; age related; base; biodefense; combat; flexibility; innovation; novel; pathogen; product development; programs; research and development; therapeutic vaccine; vaccine development

The goal of the Developmental Research Plan is to identify and support pilot projects that complement the strategic mission of the PNWRCE. The PNWRCE will advance strategies to combat NIAID Category A-C agents via the development of two themes: "Identification of age-related defects in the immune system to facilitate the development of vaccines and supplemental therapies" and "The use of systems biology and systems genetics approaches to define pathogen-host interactions and mechanisms of innate and adaptive immunity." Applications will be encouraged from scientists within the RCE and from eligible regional scientists wishing to move into biodefense/EID research. Thus, we will leverage the pilot project mechanism to expand the scope and excellence of biodefense/EID research in the PNW region and develop a cutting edge research portfolio to sustain and enrich Center's activities. Three Specific Aims are proposed to achieve these goals: (1) To solicit, identify and support developmental research projects ("pilot" projects) that expand the scope and range of investigators within the Pacific Northwest (PNW) region and take advantage of novel ideas and emerging technologies relevant to PNWRCE themes. (2) To support the growth of successful pilot projects into independent research grants that will lead to development of products (vaccines, therapeutics or diagnostics) against NIAID A-C pathogens or key advances in biodefense/EID research. (3) To create, through the pilot project mechanism, a platform of emergent talents and technologies that could enhance or replace existing research projects, thereby creating flexibility for the Center to prioritize and advance in the most promising research directions. We will use electronic communication systems in association with established translational research initiatives in Oregon (OCTRI) and Washington (CTSA) to solicit applications from a broad talent base of eligible scientists. In accordance with NIAID policies, we will select, fund and manage successful applications via an interactive committee of Center scientists, administrators and external advisors. Our mission is to maintain the Center's excellence through supporting projects with high potential for product development and maturation into independent research programs.

发展研究计划的目标是确定和支持试点项目，以补充 PNWRCE 的战略使命。 PNWRCE 将推进对抗 NIAID A-C 类的策略 通过开发两个主题的药物：“识别免疫系统中与年龄相关的缺陷 促进疫苗和补充疗法的开发”和“利用系统生物学和 系统遗传学方法来定义病原体-宿主相互作用以及先天和适应性的机制 免疫。”将鼓励 RCE 内的科学家和符合条件的地区科学家提出申请。 希望进入生物防御/EID 研究的科学家。因此，我们将利用试点机制 扩大 PNW 地区生物防御/EID 研究的范围和卓越性，并开发一种切割技术 边缘研究组合以维持和丰富中心的活动。提出了三个具体目标 实现这些目标： (1) 征求、确定和支持开发研究项目（“试点”项目）， 扩大西北太平洋 (PNW) 地区调查人员的范围和范围，并利用 与 PNWRCE 主题相关的新颖想法和新兴技术。 （二）支持发展 成功的试点项目转化为独立研究资助，这将导致产品的开发 针对 NIAID A-C 病原体的（疫苗、治疗或诊断）或生物防御/EID 的关键进展 研究。 （三）通过试点机制，打造新兴人才平台 可以增强或取代现有研究项目的技术，从而为研究创造灵活性 中心优先考虑并推进最有前途的研究方向。我们将使用电子 与俄勒冈州已建立的转化研究计划 (OCTRI) 相关的通信系统 和华盛顿州（CTSA），向广泛的合格科学家人才库征求申请。根据 根据 NIAID 政策，我们将通过一个互动委员会来选择、资助和管理成功的申请 中心科学家、管理人员和外部顾问。我们的使命是保持中心的卓越性 通过支持具有高潜力的产品开发和成熟为独立的项目 研究计划。