Data Management and Coordinating Center (DMCC)

数据管理和协调中心（DMCC）

基本信息

批准号：
8330246
负责人：
JEFFREY P KRISCHER
金额：
$ 307.55万
依托单位：
UNIVERSITY OF SOUTH FLORIDA
依托单位国家：
美国
项目类别：
财政年份：
2003
资助国家：
美国
起止时间：
2003-09-30 至 2014-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8330246
关键词：
Access to Information Accountability Address Adherence Administrator Adverse event Agreement Algorithms Architecture Archives Area Automatic Data Processing Beds Biological Biological Markers Biological Neural Networks Bite Businesses Cancer Patient Case Report Form Cellular Phone Characteristics Classification Clinic Visits Clinical Clinical Data Clinical Investigator Clinical Management Clinical Protocols Clinical Research Clinical Research Associate Clinical Research Protocols Clinical Trials Clinical Trials Cooperative Group Clinical Trials Data Monitoring Committees Code Collaborations Collection Committee Members Common Data Element Common Terminology Criteria for Adverse Events Communication Communities Computer Architectures Computer Security Computer software Computers Confidentiality Consent Forms Cost Savings Custom Cystic Fibrosis Data Data Analyses Data Base Management Data Collection Data Element Data Protection Data Quality Data Reporting Data Security Data Set Databases Decision Trees Descriptor Development Diagnosis Diagnostic radiologic examination Directories Disasters Disease Documentation Drops Drug Monitoring Electronic Mail Electronics Eligibility Determination Engineering Enrollment Ensure Environment Epidemiology Etiology Evaluation Event Exclusion Criteria Expert Systems Extensible Markup Language Faculty Family Feedback Flare Foundations Freezing Frequencies Funding Future General Population Generations Generic Drugs Genetic Genetic Transcription Genus - Lotus Grant Graph Grouping Growth Guidelines Hand Health Human Resources Image Individual Industry Informatics Information Networks Information Systems Informed Consent Institution Institutional Review Boards Insulin-Dependent Diabetes Mellitus International Internet Interview Label Laboratories Laboratory Research Language Laws Lead Learning Letters Libraries Life Link Location Logic Machine Learning Magnetic Resonance Imaging Mails Malignant Neoplasms Manuals Maps Measures Mechanics Medical Medical History Methodology Methods Metric Modeling Monitor Monitoring Clinical Trials Nature Neurofibromatoses Notification Online Systems Optics Outcome Study Pamphlets Paralysed Participant Pathologic Pathology Patient Outcomes Assessments Patient Self-Report Patients Performance Persons Pharmacy facility Phase Physical environment Physicians Pilot Projects Policies Population Population Study Positron-Emission Tomography Prevention strategy Principal Investigator Printing Privacy Procedures Process Production Programming Languages Proteomics Protocol Compliance Protocols documentation Publications Published Directory Publishing Qualifying Quality Control Quality of life Radiology Specialty Randomized Rare Diseases Reader Recording of previous events Records Recovery Recruitment Activity Registries Regulation Relative (related person)Reporting Research Research Design Research Infrastructure Research Personnel Research Subjects Resolution Resources Risk Role SNOMED Clinical Terms Sampling Scanning Schedule Scientist Secure Security Selection Bias Self Assessment Services Side Single-Gene Defect Site Site Visit Source Specific qualifier value Specimen Stream Structure Support Groups Support System System Techniques Technology Test Result Testing Text Time Training Translations Trees U-Series Cooperative Agreements United States National Institutes of Health Update Validation Variant Videoconferences Videoconferencing Visit Visual Voice Work X-Ray Computed Tomography base clinical research site cluster computing computer science computerized data processing data acquisition data management data mining data modeling data sharing database design database structure demographics design distributed data electronic data eligible participant experience federal policy federated computing firewall follow-up forest graphical user interface improved information display interest meetings member new technology novel strategies operation optical character recognition patient advocacy group patient registry predictive modeling professor programs prospective protocol development quality assurance radiologist remediation repository research study response sample collection software development statistics success symposium technology development therapeutic development tool trafficking user-friendly vector volunteer web interface web page web services web site working group

项目摘要

This application seeks funding for the Data Management and Coordinating Center (DMCC) (formerly known as Data Technology Coordinating Center, DTCC) for the Rare Diseases Clinical Research Network (RDCRN). The applicant, Dr. Krischer, has served as the Principal Investigator for the DTCC for the last 5 years and seeks to renew the cooperative agreement for the DMCC which supports the Rare Diseases Clinical Research Network (RDCRN). The DMCC propose to extend the systems, processes, and procedures developed successfully over the last grant cycle to accommodate the 3000 subjects enrolled on 32 current studies, contingent upon the successful re-competition of their associated clinical research consortia, addition of new studies reflecting the growth of the network, accommodation of federated databases, work with consortia that have pre-existing infrastructure (registries, patient databases, etc.) and registries, provide a user friendly website for web-based recruitment which receives over 3.4 million hits per year at present and a 4000+ member contact registry enhanced for subjects seeking enrollment on clinical trials. We will continue development of new technologies to support scalability and generalizability and tools for cross-disease data mining. Our international clinical information network is secure providing coordinated data management services for collection, storage and analysis of diverse data types from multiple diseases and geographically disparate locations and a portal for the general public and larger community of clinical investigators.

本申请为数据管理和协调中心 (DMCC)（以前称为作为罕见疾病临床研究网络数据技术协调中心 (DTCC) （RDCRN）。申请人Krischer博士在过去5年担任DTCC的首席研究员年并寻求续签支持罕见疾病的 DMCC 合作协议临床研究网络（RDCRN）。 DMCC 提议扩展系统、流程和在上一个拨款周期中成功开发了程序，以适应 3000 名受试者的注册 32 项当前研究，取决于其相关临床研究能否成功重新竞争联盟、增加反映网络增长的新研究、联盟的住宿数据库，与拥有现有基础设施（登记处、患者数据库等）的联盟合作，以及注册中心，为基于网络的招聘提供用户友好的网站，每个网站的点击量超过 340 万次目前已加强了 4000 多名会员联系登记处，以供寻求临床注册的受试者使用试验。我们将继续开发支持可扩展性和通用性的新技术和工具用于跨疾病数据挖掘。我们的国际临床信息网络是安全的，可提供协调的用于收集、存储和分析多种疾病的多种数据类型的数据管理服务和地理位置不同的地方，以及面向公众和更大的临床社区的门户调查人员。