Healthy Brain and Child Development National Consortium Data Coordinating Center

健康大脑和儿童发展国家联盟数据协调中心

• 批准号: 10666586
• 负责人: ANDERS M DALE
• 金额: $ 421.71万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-30 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10666586
• 关键词: Accountability; Accounting; Address; Affect; Age; Behavior assessment; Behavioral; Bioinformatics; Biological; Biological Factors; Biometry; Birth; Brain; Characteristics; Child; Child Development; Child Health; Childhood; Clinical; Clinical Data; Cohort Studies; Collaborations; Collection; Communities; Data; Data Analyses; Data Analytics; Data Collection; Data Coordinating Center; Data Set; Databases; Development; Electroencephalography; Electronic Health Record; Enrollment; Ensure; Environment; Environmental Exposure; Environmental Impact; Environmental Risk Factor; Epidemiology; Ethnic Origin; Evaluation; Family; Genetic; Goals; Health Insurance Portability and Accountability Act; Helping to End Addiction Long-term; Heterogeneity; High Performance Computing; Infant; Infrastructure; Investigation; Leadership; Life; Link; Location; Magnetic Resonance Imaging; Measures; Methods; Modality; Monitor; Mothers; Opiate Addiction; Opioid; Parents; Participant; Personal Satisfaction; Personally Identifiable Information; Persons; Policies; Population; Pregnancy; Pregnant Women; Privacy; Procedures; Protocols documentation; Public Health; Public Policy; Quality Control; Questionnaires; Race; Regulation; Reproducibility; Research; Resources; Sampling; Schedule; Secure; Shapes; Site; Spectrum Analysis; Speed; Standardization; Statistical Data Interpretation; System; Technology; Time; Toddler; Training; United States National Institutes of Health; Vendor; Vertebral column; Woman; access restrictions; behavioral health; behavioral outcome; brain health; clinical care; clinical data warehouse; cognitive testing; cohort; computerized data processing; computing resources; critical period; data access; data and analysis portal; data collection site; data exploration; data harmonization; data management; data registry; data resource; data tools; demographics; design; electronic health data; electronic health record system; experience; fetal substance exposure; flexibility; follow-up; high dimensionality; high risk; improved; infancy; innovation; longitudinal dataset; magnetic resonance imaging/electroencephalography; multidisciplinary; multimodal data; multimodality; neurobehavioral; neurodevelopment; neuroimaging; neurophysiology; new technology; opioid misuse; prenatal; prospective; recruit; resilience; sociodemographics; socioeconomics; stem; substance use; success; therapy design; tool; validation studies; wearable sensor technology

PROJECT SUMMARY The landmark Healthy Brain and Child Development (HBCD) study will provide a representative reference data resource to the scientific community enabling unprecedented investigation of neurodevelopment and the impact of environmental, genetic, and biological factors on brain and behavioral health and developmental trajectories from infancy through childhood. Through this study, the Healthy Brain and Child Development National Consortium (HBCD-NC) will recruit and retain a sociodemographically diverse cohort of 7,500 pregnant women from 24 sites across the U.S. and follow these families and their children through the first decade of life. Children will undergo rigorous data collection across modalities including neuroimaging, neurophysiology, behavioral and cognitive assessments, and collection of biospecimens via a balanced protocol developed by field-leading experts. Building upon the substantive complementary experience and expertise of its multidisciplinary team and leveraging multiple population-specific technical innovations, the Healthy Brain and Child Development National Consortium Data Coordinating Center (HDCC) will provide the leadership, management, and oversight of data collection, quality control, curation, processing, management, sharing, and analytics to facilitate and support the activities of the HBCD-NC and ensure its success. Included is development and implementation of an optimized, state-of-the-art MRI protocol harmonized for the first time in infants/toddlers across all three major vendors which leverages the latest innovations in scanner technology with age-specific structural, microstructural, quantitative, functional, and spectroscopy sequences. Also detailed is a targeted EEG protocol linked with a field-leading automated processing pipeline for developmental EEG which provides innovative derivative measures. Data and project management will occur through a centralized tracking and distribution platform linked to a high-throughput compute backbone which overcomes limits of commercially-available systems for management and integrated processing of multimodality data from large, multi-site studies. High performance computing will be supported through unique access to a combination of field-leading resources. Detailed procedures are outlined for secure collection, management, and analysis of personally identifiable information (PII) data, including flexible methods designed to accommodate heterogeneity in electronic health record systems across sites. Finally, substantive HBCD-specific enhancements to the Data Exploration and Analysis Portal (DEAP 2.0) will produce a crucial tool for data access to authenticated users while promoting best practices in reproducible statistical analysis and providing flexible computation without the need to download restricted-access data. The result of this field- leading combination of HDCC resources will be a state-of-the-art, longitudinal data set of unparalleled scale which provides deep understanding of the biological and environmental factors that affect a child’s health, brain, and behavioral development and shapes research, clinical care, and public policy for decades to come.

项目摘要 地标健康的大脑和儿童发展（HBCD）研究将提供代表性参考数据 科学界的资源，使神经发育和影响的前所未有的调查 关于大脑以及行为健康和发育轨迹的环境，遗传和生物学因素 从婴儿期到童年。通过这项研究，健康的大脑和儿童发展国家 财团（HBCD-NC）将招募并保留7,500名孕妇的社会人口统计学群体 来自美国各地的24个地点，并在生命的前十年跟随这些家庭及其子女。孩子们 将跨神经影像，神经生理学，行为和行为和 认知评估和通过现场领先制定的平衡协议收集生物测量 专家。基于其多学科团队的实质性完整经验和专业知识和专业知识 利用多种人群特定的技术创新，健康的大脑和儿童发展国家 财团数据协调中心（HDCC）将提供数据的领导，管理和监督 收集，质量控制，策展，处理，管理，共享和分析，以促进和支持 HBCD-NC的活动并确保其成功。包括的开发和实施是优化的， 最先进的MRI协议首次在婴儿/幼儿中首次在所有三个主要供应商中进行协调 利用扫描仪技术的最新创新，并具有特定年龄的结构，微结构，定量， 功能和光谱序列。还详细介绍的是与现场领导链接的目标脑电图协议 发育性脑电图的自动加工管道，提供创新的导数措施。数据和 项目管理将通过与高通量相关的集中跟踪和分销平台进行 计算主链，该主链克服了商业上可用系统的限制进行管理和集成 从大型多站点研究中处理多模式数据。高性能计算将得到支持 通过独特的访问现场领先资源的组合。概述了详细的程序 个人身份信息（PII）数据的收集，管理和分析，包括灵活的方法 旨在适应跨站点的电子健康记录系统中的异质性。最后，实质性 HBCD特定的数据探索和分析门户网站（DEAP 2.0）将产生关键工具 在促进可再现统计分析和 提供灵活的计算，而无需下载限制访问数据。这个字段的结果 HDCC资源的领先组合将是无与伦比的最先进的纵向数据集 这提供了对影响儿童健康的生物学和环境因素的深入了解 几十年来，行为发展和塑造研究，临床护理和公共政策。