ABCD-USA Consortium: Data Analysis Center

ABCD-美国联盟：数据分析中心

基本信息

批准号：
9564268
负责人：
ANDERS M DALE
金额：
$ 10万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-09-30 至 2020-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9564268
关键词：
10 year old Address Adolescent Adolescent Development Alcohol or Other Drugs use Alcohols American Behavioral Bioinformatics Biological Biological Assay Brain Brain imaging Calibration Child Child Development Childhood Clinical assessments Communities Computer Analysis Data Data Analyses Data Collection Development Diffusion Magnetic Resonance Imaging Ensure Environment Epidemiology Functional Magnetic Resonance Imaging Future Genetic Genetic study Geography Goals Human Image Individual Informatics Link Machine Learning Magnetic Resonance Imaging Marijuana Measures Mental Health Methodology Modality Monitor Neurobiology Neurocognition Neurocognitive Online Systems Outcome Participant Pattern Phenotype Population Procedures Process Protocols documentation Psychopathology Quality Control Questionnaires Recruitment Activity Reporting Research Research Design Research Infrastructure Research Personnel Research Project Grants Rest Risk Sampling Site Social Functioning Standardization Statistical Data Interpretation Surveys Symptoms Technology Technology Assessment Testing Time Twin Multiple Birth Uncertainty adolescent brain development adolescent substance use base behavioral health cognitive development cognitive neuroscience cognitive testing cohesion computer infrastructure computerized connectome data modeling design early onset emerging adult experience handheld mobile device imaging genetics imaging study informatics infrastructure marijuana use misuse of prescription only drugs mobile computing multimodality neuroimaging novel public health relevance success time use tool trend

项目摘要

DESCRIPTION (provided by applicant): The ABCD-USA Consortium proposes a study designed to permit the scientific community to answer important questions about the effects of substance use (SU) patterns on behavioral and brain development of adolescents. We have assembled a team of investigators with unparalleled research experience with children and adolescents, and specific expertise in adolescent SU, child and adolescent development, developmental psychopathology, longitudinal multi-site imaging, developmental neuroimaging, developmental cognitive neuroscience, genetics and imaging genetics, bioassays, epidemiology, survey research, bioinformatics, and mobile assessment technologies. We propose a comprehensive, nationwide study to be conducted at 21 sites organized into 11 hubs (over 89 million Americans, 29% of the US population, live within 50 miles of our geographically spread sites), that, uniquely, can provide a nationally representative sample and a large twin sample that together can help distinguish environmental, sociocultural, and genetic factors relevant to SU. We ensure cohesion and standardization by employing a recruitment strategy designed by a professional survey company (experience with Monitoring the Future); standardized environmental, neurocognitive and mental health assessments, MRI assessments with all scanners using harmonized Human Connectome Project procedures, and computerized data collection with real-time quality control. Developmentally tailored assessments will have stable sensitivity and construct validity across the childhood and adolescent developmental period. They minimize participant burden, yet capture even subtle changes over time in substance use, mental health, neurocognition, development, and environment, and we employ novel state-of-the-art bioassays and passive data collection from mobile devices. A detailed retention plan builds on the experience and success of our investigators. This application describes the ABCD-USA Data Analysis and Informatics Center (DAIC), which will: establish a harmonized MRI acquisition protocol, compatible with all major scanner platforms, taking advantage of recent technological advances in structural and functional MRI; establish rigorous quality control and quantitative calibration procedures to ensure accuracy and comparability of derived imaging measures across scanners and across time; implement advanced computational analysis workflows for all imaging data; implement reliable data entry, quality control, and monitoring tools for the substance use questionnaire, neurocognitive assessments, bioassay-derived measures, and mobile technologies assessment data; implement the state- of-the-art statistical analysis tools and procedures needed to integrate information across measures and modalities; and implement infrastructure and procedures for public sharing of raw- and derived data and associated tools and computational workflows, and enable interactive data exploration and analytics through a web-based Portal.

描述（由适用提供）：ABCD-USA财团提案一项旨在允许科学界回答有关物质使用（SU）模式对青少年行为和大脑发展的影响的重要问题。 We have assembled a team of investigators with unparalleled research experience with children and adolescents, and specific expertise in adolescent SU, child and adolescent development, developmental psychopathology, longitudinal multi-site imaging, developing neuroimaging, developing cognitive neuroscience, genetics and imaging genetics, bioassays, epidemiology, survey research, bioinformatics, and mobile assessment technologies.我们提出了一项全面的全国研究，将在有21个枢纽的21个地点进行（超过8900万美国人，美国29％的美国人口，居住在我们地理位置传播的地点50英里以内），独特地可以提供一个全国代表性的样本和大型的双胞胎样本，共同有助于区分环境环境，社会文化和遗传因素。我们通过采用专业调查公司设计的招聘策略来确保凝聚力和标准化（监视未来的经验）；标准化的环境，神经认知和心理健康评估，使用协调的人类连接项目程序进行所有扫描仪的MRI评估以及具有实时质量控制的计算机数据收集。经过开发量身定制的评估将在整个儿童期和青少年发育时期具有稳定的灵敏度和构建有效性。他们最大程度地减少了参与者的燃烧，但随着时间的使用，心理健康，神经认知，发展和环境捕捉了甚至随着时间的流逝而微妙的变化，我们采用了新型的最先进的生物测定和移动设备设备的被动数据收集。详细的保留计划以我们的调查人员的经验和成功为基础。该应用程序描述了ABCD-USA数据分析和信息学中心（DAIC），该中心将通过结构和功能MRI的最新技术进步，建立与所有主要扫描仪平台兼容的协调MRI获取协议；建立严格的质量控制和定量校准程序，以确保扫描仪和整个时间的派生成像测量的准确性和可比性；实施所有成像数据的高级计算分析工作流程；为物质使用问卷，神经认知评估，生物测定衍生的测量以及移动技术评估数据实施可靠的数据输入，质量控制和监视工具；实施跨测量和方式整合信息所需的最新统计分析工具和程序；并实施基础架构和程序，以公开共享原始数据和相关的工具以及计算工作流程，并通过基于Web的门户启用交互式数据探索和分析。