Pharmacokinetics/Pharmacodynamics (PK/PD) Core

药代动力学/药效学 (PK/PD) 核心

• 批准号: 8292412
• 负责人: BARBARA R GRUBB
• 金额: $ 35.72万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8292412
• 关键词: Affect; Animals; Chronic Obstructive Airway Disease; Clinical; Coughing; Deposition; Diagnostic Imaging; Drug Kinetics; Engineering; Exhalation; Heterogeneity; Human; Hydration status; Image; Inflammation; Intervention; Irrigation; Label; Lung; Magnetic Resonance Imaging; Measurement; Measures; Methods; Modeling; Movement; Mucociliary Clearance; Mucolytics; Mucous body substance; Mus; Obstructive Lung Diseases; Patients; Pharmaceutical Preparations; Pharmacodynamics; Positron-Emission Tomography; Research Personnel; Sampling; Shapes; Site; Sputum; Structure; Surface; Techniques; Time; Uncertainty; airway obstruction; airway surface liquid; human subject; in vivo; novel; particle; radiotracer; response; single photon emission computed tomography

The PK/PD Core will provide 1) pharmacokinetic (PK) measurements of drug concentrations over time in airway surface liquid (ASL) from all three projects and 2) in-vivo pharmacodynamic (PD) measurements of mucociliary and cough clearance (MCC/CC) for the animal and human projects (Projects II and 111).

PK/PD核心将提供1）药代动力学（PK）测量药物浓度随着时间的流逝，这三个项目的气道表面液体（ASL）和2个项目中的药物浓度（ASL）对粘膜和库酸盐清除率（MCC/CC）的体内药效学（PD）测量（动物和人类项目II和人类项目II和111）。