Auditory Information Processing in the Amygdala

杏仁核的听觉信息处理

• 批准号: 8320439
• 负责人: JEFFREY JAMES WENSTRUP
• 金额: $ 52.4万
• 依托单位: NORTHEAST OHIO MEDICAL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-12-01 至 2017-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8320439
• 关键词: Acoustic Stimulation; Acoustics; Address; Affect; Aggressive behavior; Amygdaloid structure; Animal Model; Animals; Auditory; Autistic Disorder; Behavior; Behavioral; CBA/CaJ Mouse; Chiroptera; Chronic; Communication; Cues; Dependence; Discrimination; Disease; Emotional; Female; Freezing; Functional Magnetic Resonance Imaging; Functional disorder; Future; Goals; Hearing; Human; Individual; Long-Term Effects; Measures; Mus; Neurons; Odors; Pattern; Play; Process; Randomized; Role; Schizophrenia; Sensory; Signal Transduction; Speech; Stimulus; Stress; Structure; Testing; Thalamic structure; Tinnitus; Training; Work; auditory stimulus; awake; base; conditioned fear; improved; information processing; male; neuromechanism; neurophysiology; research study; response; restraint; social; sound; vocalization

DESCRIPTION (provided by applicant): The long-term goal of this work is to improve the understanding of neural mechanisms that underlie acoustic communication. This project focuses on the amygdala, a structure known for its role in auditory fear conditioning. For this role, it receives auditory input from the thalamus and cortex, contributes to identifying a stimulu as aversive, and provides for appropriate emotional responses (e.g., autonomic responses, freezing). Recent work demonstrates a broader role for the amygdala in auditory behavior, including acoustic communication. This work is based on the view that the amygdala plays a critical role in acoustic communication through participation in several processes. 1) The amygdala "decides" whether a vocal signal is salient and whether that salience is positive or negative, based on contextual information from the vocal sequence, other sensory information, and the animal's internal state, 2) It orchestrates emotional responses that are appropriate for the received vocal communication signals and their context, 3) It modulates responsiveness to subsequent vocal signals through its direct and indirect projections to cortical and other auditory structures. In other words, the amygdala is likely to influence how we hear and respond to vocal communication signals. Understanding how the amygdala contributes to acoustic communication has been limited by lack of information on how amygdalar neurons respond to communication signals. Do amygdalar neurons discriminate among social vocalizations? What features of the auditory-evoked spike trains signal discrimination? How does contextual information modify the discrimination and discharge pattern of amygdalar neurons in response to social vocalizations? These questions are addressed within three Specific Aims that investigate the dependence of auditory responses on several forms of stimulus context: acoustic context (the sequencing of composition of vocalizations) (Aims1), other sensory context (Aim 2), and internal state (Aim 3). Auditory responses are obtained using chronic recording from the amygdala of awake, unrestrained animals in most experiments. Two animal models, big brown bats and CBA/CaJ mice, each provide particular advantages for the proposed studies. Dysfunction in the amygdala may play a critical role in abnormal relationships between acoustic inputs and emotional responses in disorders such as autism, schizophrenia, post-traumatic stress, and tinnitus. This work lays groundwork for study of the function of the amygdala in animal models of these disorders. PUBLIC HEALTH RELEVANCE: Dysfunction in the amygdala may play a critical role in the abnormal emotional responses to speech and other sounds that occurs in autism, schizophrenia, post-traumatic stress, and tinnitus. This work will establish how amygdalar neurons normally function in response to speech-like sounds, laying groundwork for study of the function of the amygdala in animal models of these disorders. !

描述（由申请人提供）：这项工作的长期目标是提高对声学沟通基础的神经机制的理解。该项目着重于杏仁核，杏仁核是一种以其在听觉恐惧条件中的作用而闻名的结构。对于此角色，它从丘脑和皮质中接收听觉输入，有助于识别刺激是厌恶的，并提供了适当的情感反应（例如，自主响应，冻结）。最近的工作表明，杏仁核在听觉行为（包括声学交流）中发挥了更广泛的作用。这项工作基于这样的观点，即杏仁核通过参与多个过程在声学交流中起着至关重要的作用。 1）杏仁核“决定”声信号是显着的，以及这种显着性是正面还是负面的，基于声音序列中的上下文信息，其他感觉信息和动物的内部状态，2）它协调情绪响应，它适合于接收到的声音沟通信号及其上下文，并通过其直接响应的响应能力，3）它可以调节其直接的响应能力，3）它的直接响应能力，3）它的直接响应能力，3）它的直接响应能力，3） 结构。换句话说，杏仁核可能会影响我们听到和响应声音交流信号的方式。缺乏有关杏仁核神经元如何响应通信信号的信息，了解杏仁核如何对声学交流的贡献受到限制。杏仁核神经元是否在社会发声中歧视？听觉诱发的尖峰列车的哪些功能信号歧视？上下文信息如何改变杏仁核神经元的歧视和放电模式，以响应社会发声？这些问题在三个特定的目的中解决了这些问题，这些目标研究了听觉反应对几种刺激环境的依赖性：声学环境（声音的组成的测序）（AIMS1），其他感觉环境（AIM 2）和内部状态（AIM 3）。在大多数实验中，使用从清醒，不受约束的动物的杏仁核中使用慢性记录获得听觉反应。两种动物模型，大棕色蝙蝠和CBA/CAJ小鼠，每种动物模型为拟议的研究提供了特殊的优势。杏仁核的功能障碍可能在声学输入和情绪反应之间的异常关系中起关键作用，例如自闭症，精神分裂症，创伤后压力和耳鸣。这项工作为研究杏仁核在这些疾病的动物模型中的功能奠定了基础。 公共卫生相关性：杏仁核的功能障碍可能在对自闭症，精神分裂症，创伤后压力和耳鸣的异常情感反应和其他声音中发挥关键作用。这项工作将确定杏仁核神经元通常如何响应言语声音，为研究这些疾病动物模型中杏仁核的功能的基础。呢