Academic achievement of children and adolescents with oral clefts

患有唇裂的儿童和青少年的学业成绩

基本信息

批准号：
8309128
负责人：
George L Wehby
金额：
$ 16.26万
依托单位：
UNIVERSITY OF IOWA
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-08-01 至 2015-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8309128
关键词：
6H,8H-3,4-dihydropyrimido(4,5-c)(1,2)oxazin-7-one Academic achievement Accounting Achievement Address Adolescence Adolescent Adult Adverse effects Affect Age Birth Birth Records Caring Characteristics Child Childhood Chronic Cleft Lip Cleft Palate Clinic Cognitive Congenital Abnormality Congenital Disorders Control Groups Data Dental Economics Education Educational Status Environment Family Future Goals Growth Health Inborn Genetic Diseases Individual Infant Development Inherited Intervention Iowa Knowledge Language Life Link Mathematics Measures Medical Operative Surgical Procedures Outcome Palate Pathway interactions Performance Policies Population Pregnancy Prevention Public Policy Quality of life Reading Recurrence Registries Reliance Reporting Research Infrastructure Risk Risk Factors Sampling Sampling Studies Schools Science Severities Siblings Socioeconomic Status Speech Therapy Surveys Syndrome Testing Time Universities Validity and Reliability base cognitive function cost effective design ear infection economic outcome effective intervention feeding human capital improved innovation longitudinal design mortality neuropsychological oral cleft population based programs psychologic psychosocial repaired socioeconomics suicidal risk

项目摘要

DESCRIPTION (provided by applicant): Cleft lip and/or palate (CL-P) are common birth defects occurring in about 1/500 to 1/2500 births. Nonsyndromic (NS) forms occurring without other major birth defects or syndromes are the most common and impose large early and long-term adverse effects on the health of affected individuals by increasing the risks for mortality and certain chronic conditions. NSCL-P may also reduce educational, psychosocial, and economic achievement. Understanding the NSCL-P effects on educational achievement is needed for understanding the pathways through which NSCL-P affects health and psychosocial and economic performance given the important effects of education on these outcomes. Furthermore, obtaining accurate estimates of the NSCL-P effects and how they vary by socioeconomic, demographic and health backgrounds is essential for identifying needs and developing cost-effective policies and interventions to improve the wellbeing of affected individuals. However, much remains unknown about the NSCL-P effects on the educational achievement of affected individuals. A few studies report adverse effects on cognitive performance and/or educational achievement early in life and throughout adulthood. However, these studies are limited by small clinic-based samples, lack of appropriate control groups, and cross-sectional designs that ignore changes over time. Furthermore, none of these studies identifies socioeconomic, demographic or health factors that may interact with and modify the effects of NSCL-P on educational achievement. The proposed study will identify the impacts of NS CL-P on the educational achievement of children and adolescents with oral clefts and assess how these impacts vary by socioeconomic, demographic and health backgrounds. The study is highly innovative by employing a unique, existing data infrastructure to implement the study Specific Aims and by addressing several of the limitations of previous studies. We will study a large population-based sample of individuals with oral clefts from Iowa identified through the Iowa Registry for Congenital and Inherited Disorders (IRCID) and multiple control groups including siblings, classmates, and unaffected children from the National Birth Defects and Prevention Study (NBDPS). This multi-control group approach provides significant methodological advantages over previous studies. We measure educational achievement using the objective standardized Iowa school tests that were developed and are maintained at the University of Iowa and have high reliability and validity. We will evaluate scores on Reading, Mathematics, Language, and Science as well as overall composite scores. We will also link data from birth records and NBDPS survey data on health and socioeconomic and demographic characteristics and risk factors during pregnancy. Furthermore, we study the effects of NSCL-P on educational achievement and its changes with age using longitudinal designs. The study will add significant knowledge about the NSCL-P effects on educational achievement and about ways to improve the long-term outcomes of affected individuals.

描述（由申请人提供）：唇裂和/或口感（Cl-P）是大约1/500至1/2500出生的常见出生缺陷。没有其他主要的先天缺陷或综合征出现的非综合征（NS）形式是最常见的，并且通过增加死亡率和某些慢性病的风险，对受影响个体的健康造成了很大的早期和长期不利影响。 NSCL-P还可以减少教育，社会心理和经济成就。需要了解NSCL-P对教育成就的影响，以了解NSCL-P会影响健康，社会心理和经济绩效的途径，鉴于教育对这些结果的重要影响。此外，获得NSCL-P效应的准确估计以及它们如何随社会经济，人口统计和健康背景而变化，对于确定需求并制定成本效益的政策和干预措施至关重要，以改善受影响个人的福祉。但是，关于NSCL-P对受影响个人的教育成就的影响，尚不清楚。一些研究报告了对认知表现和/或整个成年期的认知表现和/或教育成就的不利影响。但是，这些研究受到基于小型诊所的样本的限制，缺乏适当的对照组以及忽略随时间变化的横断面设计。此外，这些研究均未确定可能与NSCL-P对教育成就的影响并修改社会经济，人口统计或健康因素。拟议的研究将确定NS CL-P对口腔裂缝儿童和青少年的教育成就的影响，并评估这些影响如何因社会经济，人口统计和健康背景而异。通过采用独特的现有数据基础架构来实施该研究的特定目的并解决先前研究的一些局限性，这项研究具有高度创新性。我们将研究通过爱荷华州先天和遗传疾病（IRCID）和多个对照组（包括兄弟姐妹，同学和来自国家出生缺陷和预防研究（NBDPS））的多个对照组（包括兄弟姐妹，同学和未受影响的儿童）的大量基于人群的口腔裂口样本。这种多控制组方法比以前的研究具有显着的方法论优势。我们使用在爱荷华大学开发并维持的客观标准化的爱荷华州学校测试来衡量教育成就，并具有很高的可靠性和有效性。我们将评估阅读，数学，语言和科学以及整体综合分数的分数。我们还将在怀孕期间从出生记录和NBDPS调查数据中链接有关健康，社会经济和人口统计学特征和危险因素的调查数据。此外，我们研究了NSCL-P对使用纵向设计的教育成就及其随着年龄的变化的影响。该研究将增加有关NSCL-P对教育成就的影响以及改善受影响个人长期结果的方法的重要知识。