Biospecimens

生物样本

• 批准号: 8561357
• 负责人: Ahmet Dogan
• 金额: $ 1.01万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-20 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8561357
• 关键词: Biological; Cells; Chronic Lymphocytic Leukemia; Classification; Clinic; Clinical; Clinical Trials; DNA; Data; Databases; Development; Enrollment; Ensure; Epidemiologic Studies; Ethers; Extramural Activities; Family Study; Freezing; Funding; Future; Goals; Grant; Human; Iowa; Link; Lymphoma; Malignant Neoplasms; Molecular; Molecular Epidemiology; Newly Diagnosed; Outcome; Paraffin; Patients; Plasma; Process; Protocols documentation; Publications; Quality Control; Research; Research Personnel; Research Project Grants; Resource Sharing; Resources; Sampling; Serum; Services; Small-Cell Lymphoma; Specialized Program of Research Excellence; Specimen; Tissues; Translating; Translational Research; Tumor Tissue; Universities; Work; career development; genome wide association study; improved; meetings

The Iowa-Mayo SPORE Biospecimens Shared Resource provides a coordinated, centralized, and dedicated core for the procurement, processing and annotafion of biospecimens from lymphoma patients and pafients with small lymphocytic lymphoma/chronic lymphocytic leukemia (SLL/CLL). The goal of the Biospecimens Core is to procure a variety of biologic specimens on all patients involved in UI/MC SPORE protocols and all newly diagnosed lymphoma pafients seen at the University of lowa and the Mayo Clinic Rochester, who are enrolled into the Molecular Epidemiology Resource (MER). The specific aims ef the Biospecimens Core are: 1) To provide accurate classification of all lymphomas from patients enrolled onto SPORE protocols and the MER; 2) To collect, process, bank and distribute biologic specimens from lowa and Mayo lymphoma patients for translafional research; 3) To track all biospecimens and ensure linkage to clinical, outcome and related data; and 4) Te serve as a resource of expertise, collaborative support and service for projects. All specimens are collected and processed under tight quality control, and distributed to SPORE researchers or banked for future SPORE research projects. These activities are tracked using a sophisticated database that merges the activities at lowa and Mayo, and allows integration with clinical and other data collected in research projects. The Core provides specialized expertise in working with lymphoma biospecimens and is closely aligned with institutional research cores and shared resources, but does not duplicate them. During the last funding period, the Core collected biospecimens from 7 SPORE clinical trials (>1000 samples from 193 pafients). The Core also reviewed and classified 2,461 pafients for enrollment into the MER, and collected germline DNA on >2S00 and serum on >2100 ofthe MER patients. The Core additionally banked frozen cells on -400 patients. The Cere has supported all of the full projects and multiple Developmental and Career Development projects. There has been extensive utilization of biospecimens, including use of paraffin and frozen tissue; frozen cells; germline DNA; and serum and plasma, all leading to extensive publications involving the Core. The Biospecimens Core has also partnered on other projects that have obtained extramural funding to support epidemiologic studies, family studies, genome-wide association studies, inter-SPORE studies, and other ROI and POl projects. In the next grant cycle, we will continue to accrue new patient samples to the bank and work with investigators to utilize this increasingly valuable resource to support translational research projects in lymphoma.

爱荷华州-梅奥 SPORE 生物样本共享资源提供了一个协调的、集中的、 用于淋巴瘤患者生物样本的采购、处理和注释的专用核心 以及小淋巴细胞淋巴瘤/慢性淋巴细胞白血病（SLL/CLL）患者。的目标 生物样本核心是为所有参与 UI/MC SPORE 的患者获取各种生物样本 方案以及在洛瓦大学和梅奥诊所就诊的所有新诊断的淋巴瘤患者 罗彻斯特，他们已加入分子流行病学资源 (MER)。具体目标是 生物样本的核心是：1) 对入组患者的所有淋巴瘤进行准确分类 SPORE 协议和 MER； 2) 从lowa收集、处理、储存和分发生物标本 和梅奥淋巴瘤患者进行转化研究； 3) 跟踪所有生物样本并确保链接 临床、结果和相关数据； 4) 作为专业知识、协作支持和资源的资源 为项目服务。所有样本均在严格的质量控制下收集和处理，并分发给 SPORE 研究人员或为未来的 SPORE 研究项目做好准备。这些活动是使用 复杂的数据库，合并了 lowa 和 Mayo 的活动，并允许与临床和 研究项目中收集的其他数据。核心提供淋巴瘤治疗方面的专业知识 生物样本，并与机构研究核心和共享资源密切结合，但不 复制它们。在上一个资助期间，Core 从 7 个 SPORE 临床试验中收集了生物样本 （来自 193 名患者的 1000 个样本）。核心还对 2,461 名患者进行了审查和分类，以便登记入组 MER，并收集了 >2S00 的种系 DNA 和 >2100 名 MER 患者的血清。核心 另外还储存了-400名患者的冷冻细胞。 Cere 支持所有完整项目和多个项目 发展和职业发展项目。生物样本得到了广泛的利用， 包括使用石蜡和冷冻组织；冷冻细胞；种系DNA；以及血清和血浆，所有这些都会导致 涉及核心的广泛出版物。生物样本核心还与其他项目进行了合作 已获得外部资金来支持流行病学研究、家庭研究、全基因组关联 研究、SPORE 间研究以及其他 ROI 和 POl 项目。在下一个资助周期中，我们将继续 向银行积累新的患者样本，并与研究人员合作利用这一日益有价值的样本 支持淋巴瘤转化研究项目的资源。