Health Promotion for Positives: A Randomized Trial with HIV Positive Black Men

积极健康促进：艾滋病毒阳性黑人男性的随机试验

基本信息

批准号：
8281766
负责人：
JOHN BARTON JEMMOTT
金额：
$ 41.12万
依托单位：
UNIVERSITY OF PENNSYLVANIA
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-03-21 至 2016-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8281766
关键词：
AIDS prevention AIDS-Related Opportunistic Infections Adherence Affect African American Age Aging Anti-Retroviral Agents Applications Grants Attention Behavior Behavioral Blood Pressure Body mass index Budgets Cardiovascular Diseases Centers for Disease Control and Prevention (U.S.)Chronic Chronic Disease Colon Carcinoma Comorbidity Complement Computer Assisted Control Groups Couples Data Diabetes Mellitus Diet Evidence based intervention Expectancy Future General Population Guidelines HIV HIV Infections HIV Seropositivity Health Health Promotion Health behavior Highly Active Antiretroviral Therapy Hour Hypertension Individual Intervention Interview Kidney Diseases Life Link Long-Term Effects Malignant Neoplasms Malignant neoplasm of prostate Measures Mediating Mediator of activation protein Medical Records Morbidity - disease rate Outcome Participant Patient Self-Report Persons Physical Fitness Physical activity Physiological Prevention Prostate Randomized Randomized Controlled Trials Research Risk Screening for Prostate Cancer Screening procedure Self Efficacy Testing Time Treatment Efficacy United States Vulnerable Populations Waist-Hip Ratio Walking base behavior change comparative efficacy design effective therapy efficacy testing empowered experience fitness fruits and vegetables health disparity high risk innovation interest man men mortality post intervention primary outcome randomized trial response sex social cognitive theory successful intervention theories waist circumference

项目摘要

DESCRIPTION (provided by applicant): This application is in response to RFA-MD-12-001, "NIMHD Health Disparities Research (R01)." African American men who are infected with HIV are living longer and are being impacted by the same chronic diseases that affect the general population of African American men over 40. To be sure, African American men, in general, have disproportionately high rates of cardiovascular disease, hypertension, diabetes, kidney disease, and cancer, particularly prostate and colon cancer. However, HIV infection is associated with an increased risk for co-morbidity from chronic diseases. This increased risk is heightened by HIV infection, but also its treatment with certain agents used in highly active antiretroviral therapy (HAART) combinations. Many of these chronic illnesses have behavioral components-risk is influenced by what people do and do not do, their diet, and the amount of physical activity they get. Although the high risk for multiple behavior-linked chronic diseases among HIV-positive individuals has been recognized, there is a lack of evidence-based intervention specifically tailored to their needs. Hence, the broad objective is to reduce the risk of chronic diseases among HIV positive African American men. The Specific Aims are to test the efficacy of a theory- based, contextually appropriate health promotion intervention in inducing positive changes in behaviors linked to risk of chronic diseases among HIV positive African American men age 40 years or older and to identify the theoretical variables that mediate its efficacy. The study will utilize a randomized controlled trial. The participants willbe 384 African American HIV positive men age 40 or older who are receiving HAART for HIV. The men will be randomized to a theory-based contextually appropriate health promotion intervention that involves three, 3-hour weekly intervention sessions or an attention-control group. The health promotion intervention will be an adaptation of an intervention based on social cognitive theory integrated with formative research and found to be efficacious in increasing adherence to 5-a-Day diet and physical activity guidelines and prostate cancer screening guidelines in the applicants' preliminary studies. Data will be collected at baseline, immediately post, 3, 6 and 12 months post intervention, which will permit assessment of the short- term and long-term effects of the intervention and whether the intervention's efficacy varies over time. Audio computer-assisted self-interviewing will be used to assess self-reported adherence to physical activity guidelines, 5-a-Day fruit and vegetable guidelines, prostate screening guidelines, and colon cancer screening guidelines and theoretical mediators of behavior change. Objective outcomes will include health-related fitness (6-minute walk test, 1-minute push-up test, 1-minute sit-up test, sit-and-reach test), physiological variables (blood pressure, body mass index, waist circumference, and waist-hip ratio), and prostate and colon cancer screening based on medical record review.

描述（由申请人提供）：本申请是对 RFA-MD-12-001“NIMHD 健康差异研究 (R01)”的回应。感染艾滋病毒的非洲裔美国男性寿命更长，并且受到与 40 岁以上非洲裔美国男性普通人群相同的慢性疾病的影响。可以肯定的是，非洲裔美国男性总体上心血管疾病的发病率高得不成比例。、高血压、糖尿病、肾病和癌症，特别是前列腺癌和结肠癌。然而，艾滋病毒感染与慢性疾病合并症的风险增加有关。 HIV 感染以及高活性抗逆转录病毒疗法 (HAART) 组合中使用的某些药物的治疗都会加剧这种风险的增加。许多慢性疾病都有行为因素——风险受到人们做什么和不做什么、饮食以及身体活动量的影响。尽管人们已经认识到艾滋病毒阳性个体罹患多种与行为相关的慢性疾病的高风险，但缺乏专门针对其需求的循证干预措施。因此，总体目标是降低风险 HIV 阳性非裔美国男性中慢性病的发病率。具体目标是测试基于理论、适合具体情况的健康促进干预措施在诱导 40 岁或以上 HIV 阳性非洲裔美国男性与慢性病风险相关的行为发生积极变化方面的有效性，并确定调解的理论变量它的功效。该研究将采用随机对照试验。参与者将是 384 名 40 岁或以上的非洲裔美国 HIV 阳性男性，他们正在接受 HAART 治疗 HIV。这些男性将被随机分配到基于理论、适合具体情况的健康促进干预组，其中包括每周 3 小时的干预会议或注意力控制组。健康促进干预措施将是基于社会认知理论与形成性研究相结合的干预措施的改编，在申请人的初步研究中发现，该干预措施可有效提高对每日五次饮食和身体活动指南以及前列腺癌筛查指南的遵守率。将在基线、干预后立即、干预后 3、6 和 12 个月收集数据，这将允许评估干预措施的短期和长期效果以及干预措施的功效是否随时间变化。音频计算机辅助自我访谈将用于评估自我报告的身体活动指南、每日 5 份水果和蔬菜指南、前列腺筛查指南、结肠癌筛查指南以及行为改变理论中介的遵守情况。客观结果将包括与健康相关的健身（6分钟步行测试、1分钟俯卧撑测试、1分钟仰卧起坐测试、坐姿伸展测试）、生理变量（血压、体重指数、腰围）周长、腰臀比），以及基于病历审查的前列腺癌和结肠癌筛查。