2011 Cilia, Mucus & Mucociliary Interactions Gordon Research Conference

2011 纤毛，粘液

• 批准号: 8061893
• 负责人: Mary C Rose
• 金额: $ 3.3万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-01-25 至 2011-05-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8061893
• 关键词: Adhesions; Air; Area; Asthma; Biology; Biomedical Engineering; Bronchitis; Cell Differentiation process; Cells; Chronic Obstructive Airway Disease; Cilia; Clinical; Collaborations; Cystic Fibrosis; Defense Mechanisms; Deglutition; Development; Discipline; Disease; Environment; Epithelial Cells; Faculty; Gel; Genetic; Genomics; Gland; Health; Image; Knowledge; Life; Liquid substance; Minority; Molecular; Mucins; Mucous body substance; Mutation; Pathologic; Pathologic Processes; Physiological; Physiology; Postdoctoral Fellow; Primary Ciliary Dyskinesias; Process; Production; Property; Proteomics; Regulation; Research; Research Personnel; Respiratory System; Respiratory Tract Diseases; Respiratory tract structure; Scientist; Signal Transduction; Staging; Structural Models; Structure; Structure-Activity Relationship; Students; System; Systems Biology; Technology; Therapeutic; Therapeutic Intervention; Toxin; Transcriptional Regulation; Update; Woman; airway obstruction; authority; base; chronic rhinosinusitis; driving force; insight; mathematical model; meetings; novel strategies; pathogen; pre-doctoral; sound; symposium

DESCRIPTION (provided by applicant): This proposal seeks partial support for a conference on "Cilia, Mucus and Mucociliary interactions" to be held in Ventura, CA from February 13 to 18, 2011. This is an approved Gordon Research Conference (GRC) following successful GRC-sponsored conferences of the same title held in February 2005, 2007, and 2009. This conference is unique in its focus on cilia, mucus and mucociliary interactions. These fields represent specialized scientific disciplines that are highly relevant to each other, yet are rarely combined into a single scientific conference. The scientific importance of these interconnections with respect to biology, physiology, function and disease has been increasingly recognized in recent years. The past decade has seen major advances in the basic understanding of ciliary development, properties and function; epithelial cell differentiation; mucin regulation, production and secretion; and mucus functions and interactions that have increased possibilities for therapeutic intervention at the molecular level. The exchange of ideas at this conference is a driving force for this field that impacts primarily on diseases of the respiratory tract, e.g. primary ciliary dyskinesia, cystic fibrosis, bronchitis and bronchorrhea, chronic obstructive pulmonary diseases, asthma and chronic rhinosinusitis. This GRC conference is a forum where basic and clinical researchers from diverse disciplines meet, interact, and bring new basic findings to the translational stage. The general organization is based on the established and very successful GRC formula. The objectives of this conference are: 1) To bring together world authorities and young scientists in the disciplines of fundamental process in cilia and mucus including ciliary assembly and function, epithelial cell development and differentiation, mucus/mucin function in fluids and mucosal gels, principles of mucociliary adhesion and transport, and related pathologic processes in diseases; 2) To provide a forum for presentation of new research findings and technologies, exchange of ideas, and the stimulation of new collaborations among basic, translational, and clinical researchers; 3) To integrate new knowledge by bringing together investigators using a diverse range of approaches including structural and mathematical modeling, bioengineering, imaging and computational genetics; and 4) To assure strong representation of women, minorities, and young investigators (junior faculty, fellows, predoctoral and post-doctoral students) through sound planning and organization of the meeting. The conference opens with presentations of Prospects and Themes for cilia, mucus, and mucociliary interactions. It continues with sessions on Development of ciliary and mucous components; Signaling and transcriptional control; Fundamental processes in mucus and cilia; Genetic approaches to understanding mucociliary diseases; Diseases of cilia, mucus, and mucociliary interactions; Structure-function relationships in cilia and mucus; Mucociliary interactions; and Life at the interface: cilia and fluid interactions. PUBLIC HEALTH RELEVANCE: The mucociliary system is one of the primary defense mechanisms of mammalian respiratory tracts, as mucus traps air-borne pathogens and toxins and the coordinated beating of cilia in the underlying fluid layer drives the mucus layer upward so that it can be swallowed. However, abnormalities in either quantity or physicochemical properties of the mucus produced by cells of the respiratory tract, or genetic defects in ciliary assembly or structure, leads to airway obstruction by mucus and resultant respiratory tract diseases. This conference brings together experts on cilia, mucus, and mucociliary interactions to update progress in these areas and stimulate new approaches to better understanding their impact on health and diseases.

描述（由申请人提供）：该提案为2011年2月13日至18日在CA在CA在CA举行的“纤毛，粘液和粘膜互动”会议寻求部分支持。这是一项批准的戈登研究会议（GRC），此前是在2005年FF的2005年第2007卷和2007年第2007卷和2009年的CHIUS和2009年以来的同一标题之后，在成功的GRC研究会议上获得了成功的GRC研究会议。粘膜助剂相互作用。这些领域代表了彼此高度相关的专业科学学科，但很少合并为一次科学会议。近年来，这些相互联系在生理，生理，功能和疾病方面的科学重要性越来越多。过去十年来，基本理解睫状发育，性质和功能取得了重大进展。上皮细胞分化；粘蛋白调节，生产和分泌；在分子水平上增加了治疗干预的可能性的粘液功能和相互作用。在这次会议上的思想交流是该领域的推动力，主要影响呼吸道疾病，例如原发性睫状运动障碍，囊性纤维化，支气管炎和支气管炎，慢性阻塞性肺部疾病，哮喘和慢性鼻鼻涕。这次GRC会议是一个论坛，来自不同学科的基本和临床研究人员相遇，互动并将新的基本发现带入转化阶段。通用组织基于既定且非常成功的GRC公式。这次会议的目标是：1）将世界当局和年轻科学家汇集到纤毛和粘液基本过程的学科，包括纤毛组装和功能，上皮细胞的发育和分化，粘液/粘液蛋白在液体和粘膜凝胶中的功能2）提供一个论坛，以介绍新的研究发现和技术，思想的交流以及基础，转化和临床研究人员之间新合作的刺激； 3）通过将调查人员组合在一起，使用各种方法来整合新知识，包括结构和数学建模，生物工程，成像和计算遗传学；和4）通过合理的计划和会议的组织，确保妇女，少数群体和年轻调查员（初级教师，研究员，前专业和博士后学生）的强烈代表。会议的开头是纤毛，粘液和粘膜互动的前景和主题的演讲。它继续进行有关睫状和粘液成分发展的会议。信号传导和转录控制；粘液和纤毛的基本过程；理解粘部疾病的遗传方法；纤毛，粘液和粘毛相互作用的疾病；纤毛和粘液中的结构功能关系；粘毛相互作用；和界面的生命：纤毛和流体相互作用。 公共卫生相关性：粘膜膜系统是哺乳动物呼吸道的主要防御机制之一，因为粘液捕获了空体传播病原体和毒素，以及在基础流体层中纤毛的协调跳动，使粘液层驱动粘液层，以便可以吞噬它。然而，由呼吸道细胞产生的粘液数量或物理化学特性的异常，或纤毛组装或结构中的遗传缺陷导致粘液和由此产生的呼吸道疾病的气道阻塞。这次会议汇集了有关纤毛，粘液和粘膜互动的专家，以更新这些领域的进展，并刺激新方法，以更好地理解其对健康和疾病的影响。