2011 Mammalian Gametogenesis and Embryogenesis Gordon Research Conference

2011年哺乳动物配子发生和胚胎发生戈登研究会议

基本信息

批准号：
8195123
负责人：
ROBERT E BRAUN
金额：
$ 1.2万
依托单位：
GORDON RESEARCH CONFERENCES
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-07-01 至 2012-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8195123
关键词：
Address Agriculture Animals Area Assisted Reproductive Technology Barker Hypothesis Basic Science Biological Biological Preservation Biology Cell Cycle Regulation Cells Clinical Collaborations Contraceptive methods Data Development Disease Embryo Embryology Embryonic Development Engineering Epigenetic Process Event Fostering Funding Gametogenesis Germ Cells Goals Human Infertility International Intervention Methods Minority Modeling Molecular New Hampshire Nuclear Participant Patients Pluripotent Stem Cells Process Production Reproductive Biology Reproductive Health Request for Applications Research Research Personnel Resort Scientist Stress Therapeutic Translating Translational Research Woman Work aging nutrition career career development egg meetings new technology novel novel strategies novel therapeutic intervention offspring posters programs sperm cell stem cell niche symposium

项目摘要

DESCRIPTION (provided by applicant): This application requests partial funding for the 18th Gordon Conference on Mammalian Gametogenesis and Embryogenesis to be held August 21-26, 2011 at Waterville Valley Resort in Waterville Valley New Hampshire. This conference provides a unique and valuable opportunity for discussion and the exchange of ideas between clinicians devoted to delivering the most modern therapeutic approaches to their patients, and basic scientists who are examining the biological mechanisms that underlie normal and abnormal function of gametogenesis and embryogenesis. Understanding the molecular mechanisms underlying the production of viable eggs and sperm and the initiation of embryonic development is essential for the continued survival of animal species. Advances in reproductive biology have immediate application, not only for the treatment of human infertility and subfertility, but also for improvements in developing contraceptive methods, advances in agricultural engineering and novel approaches to wildlife preservation. Moreover, stem cells, pluripotent cells, gametes and early embryos provide important models for basic research aimed at understanding epigenetics, the developmental origins of adult disease, environmental perturbation of the epigenome, nuclear programming and cell cycle regulation, as well as transcriptional, translational, and post-translational control mechanisms. These areas have potential significance for a wide variety of biomedical applications. The objective of the Gordon Conference on Mammalian Gametogenesis and Embryogenesis is to provide a forum for the exchange of the latest advances in the field, as well as to promote discussion and debate by providing a relaxed setting that fosters interaction. A particularly important aspect of the Gordon Conference setting is the blending of young and established investigators, as well as national and international scientists to promote exchanges that will generate new ideas and facilitate new collaborations. PUBLIC HEALTH RELEVANCE: Understanding the molecular mechanisms underlying the production of viable eggs and sperm and the initiation of embryonic development is essential for the creation of viable healthy offspring. Advances in reproductive biology have immediate application, not only for the treatment of human infertility and the development of new contraceptive methods, but also for a better understanding of environmental influences on the epigenome and the developmental origins of adult disease. The study of gametes and early embryos is critical to our understanding of human reproductive health and disease.

描述（由申请人提供）：本申请要求为将于 2011 年 8 月 21 日至 26 日在新罕布什尔州沃特维尔谷度假村举行的第 18 届戈登哺乳动物配子发生和胚胎发生会议提供部分资金。这次会议为致力于为患者提供最现代治疗方法的临床医生和研究配子发生和胚胎发生正常和异常功能的生物学机制的基础科学家之间的讨论和思想交流提供了独特而宝贵的机会。了解产生可行卵子和精子以及胚胎发育启动的分子机制对于动物物种的持续生存至关重要。生殖生物学的进步可以立即应用，不仅可以用于治疗人类不孕症和生育力低下，还可以用于改进避孕方法的开发、农业工程的进步和野生动物保护的新方法。此外，干细胞、多能细胞、配子和早期胚胎为基础研究提供了重要模型，旨在了解表观遗传学、成人疾病的发育起源、表观基因组的环境扰动、核编程和细胞周期调控，以及转录、翻译、和翻译后控制机制。这些领域对于各种生物医学应用具有潜在意义。戈登哺乳动物配子发生和胚胎发生会议的目标是提供一个交流该领域最新进展的论坛，并通过提供促进互动的轻松环境来促进讨论和辩论。戈登会议设置的一个特别重要的方面是年轻和成熟的研究人员以及国内和国际科学家的融合，以促进交流，从而产生新的想法并促进新的合作。公共卫生相关性：了解产生可存活卵子和精子以及启动胚胎发育的分子机制对于创造可存活的健康后代至关重要。生殖生物学的进步具有直接的应用价值，不仅可以用于治疗人类不孕症和开发新的避孕方法，还可以更好地了解环境对表观基因组的影响和成人疾病的发育起源。配子和早期胚胎的研究对于我们了解人类生殖健康和疾病至关重要。