Thrombolysis and Acute Stroke Treatment (TAST) 2011: Forward to Acute Stroke Tre

溶栓和急性中风治疗 (TAST) 2011：迈向急性中风治疗

• 批准号: 8257015
• 负责人: Gregory J Del Zoppo
• 金额: $ 1.5万
• 依托单位: NEW YORK ACADEMY OF SCIENCES
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-30 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8257015
• 关键词: Academia; Academy; Accounting; Acute; Address; Aging; Area; Attention; Award; Basic Science; Benefits and Risks; Blood flow; Brain Injuries; Caring; Cerebrovascular Disorders; Clinic; Clinical; Clinical Management; Clinical Sciences; Clinical Trials; Collaborations; Communities; Congresses; Data; Devices; Diabetes Mellitus; Diagnosis; Discipline; Disease; Educational workshop; Electronics; Evolution; Fees; Fellowship; Fibrinolytic Agents; Fostering; Foundations; Future; General Population; Generations; Goals; Grant; Guidelines; Hypertension; Individual; Industry; Injury; International; Ischemic Stroke; Knowledge; Lead; Learning; Life; Medical; Minority; Mission; Morus; Multimedia; National Institute of Neurological Disorders and Stroke; Neurology; New York; Oral; Patients; Plasminogen Activator; Prevention; Price; Printing; Publications; Recovery; Reporting; Research; Research Personnel; Resolution; Safety; Science; Scientific Advances and Accomplishments; Scientist; Series; Societies; Solutions; Stroke; Symptoms; Systemic disease; Therapeutic; Time; Travel; Universities; Work; abstracting; acute stroke; base; brain tissue; burden of illness; clinical practice; design; discount; evidence base; improved; lectures; literacy; meetings; member; multidisciplinary; nervous system disorder; neurovascular unit; posters; programs; restorative treatment; success; symposium; thrombolysis

DESCRIPTION (provided by applicant): Following ten previous international symposia on the theme of thrombolytic treatment of acute ischemic stroke, The New York Academy of Sciences (NYAS) is hosting the 11th meeting in this series: Thrombolysis and Acute Stroke Treatment (TAST) 2011: Forward to Acute Stroke Treatment in 2021. Organized by Drs. del Zoppo (PI of this grant and co-founder of this series) and Alexandrov, the Scientific Committee, Drs. Marler, Mori, and Kaste, and an International Advisory Board, this three-day conference will be held at NYAS Conference Center in New York, on 1-3 December, 2011. The goals of the symposium are to: (i) provide a neutral forum to a) generate provocative and forward-looking discussions about the state-of-the-art and future directions of research and clinical practice in the acute treatment of ischemic stroke, and b) better understand what the future holds for stroke research and patients ten years for now; (ii) highlight the research contributions of young investigators working in this field; and (iii) develop high-quality print and electronic enduring materials reporting the meeting presentations to the global scientific community. The program will feature keynote and directed plenary lectures, two mini-symposia, and a hands-on workshop, and incorporate plenty of time for networking, and audience and panel discussions. These will lead to vigorous interactions. Speakers will be explicitly asked to respond to a set of questions during their presentations to foster the generation of data-driven, multidisciplinary and focused ideas, explore ischemic stroke as a systemic disease related to other disease entities, and better address the evolution of the brain injury. Highlighted topics include: (i) the neurovascular unit and its injury; (ii) the safety and efficacy of thrombolytic agents currently used or being developed for acute stroke treatment; (iii) new views of the penumbra; (iv) time window considerations and optimized delivery conditions; (v) stabilization of brain tissue for patient recovery; (vi) enhancing the safety of plasminogen activators; (vii) factors that influence risk and benefit; and (viii) alternative approaches. We anticipate wide participation (250-300 attendees) from within and outside the immediate area of cerebrovascular disease, from basic research to clinical settings worldwide. The incorporation of poster and short presentations selected from submitted abstracts into the agenda, and the availability of discounted registration prices and travel fellowships will encourage participation from minority and young investigators. Previous meetings in the US in this series have occurred in La Jolla (1992) and Bethesda (1998), undertaken by the Scripps Clinic and Research Foundation and by the NINDS/ University of Cincinnati, respectively. Given the success in those, the timely and relevant topic, and the scientific rigor of our organizers and advisors, we anticipate a strong turnout to witness these live and enduring discussions, which will foster cross-disciplinary collaborations to promote improved treatment management, new research ideas and directions, and future guidelines for acute treatments of ischemic stroke. PUBLIC HEALTH RELEVANCE: A three-day, scientific conference at the New York Academy of Sciences will provide a neutral forum for clinicians and scientists, experts in cerebrovascular disease and related disorders, to generate provocative and forward-looking discussions to better articulate how clinical and basic science can advance blood flow restorative treatments and medical support in the coming ten to fifteen years, to promote and improve acute treatment of ischemic stroke. The program's cross-disciplinary discussions will approach ischemic stroke as a systemic disease, recognizing the contributions of hypertension, diabetes, and disorders of aging, beyond the conventional targets of time from symptoms onset to deeper understanding of basic mechanisms and the advanced science of clinical trials. This forum will also generate enduring print and online publications to highlight these discussions and make them available to the global scientific community and the general public, foster cross-disciplinary dialogue and collaborations, and promote attention toward the future medical care of stroke patients. 1

描述（由申请人提供）：继之前十次以急性缺血性中风溶栓治疗为主题的国际研讨会之后，纽约科学院 (NYAS) 将主办该系列的第 11 次会议：溶栓和急性中风治疗 (TAST) 2011 ：展望 2021 年急性中风治疗。由 Drs 组织。 del Zoppo（本次资助的 PI 和该系列的联合创始人）和科学委员会 Alexandrov 博士。由 Marler、Mori 和 Kaste 以及国际顾问委员会组成的这次为期三天的会议将于 2011 年 12 月 1 日至 3 日在纽约 NYAS 会议中心举行。 研讨会的目标是：(i) 提供中立的论坛，a) 就缺血性中风急性治疗的研究和临床实践的最新技术和未来方向进行积极和前瞻性的讨论，b) 更好地了解中风研究的未来和患者已经十年了； (ii) 突出该领域年轻研究人员的研究贡献； (iii) 制作高质量的印刷和电子持久材料，向全球科学界报告会议的发言。该计划将包括主题演讲和定向全体讲座、两个小型研讨会和一个实践研讨会，并包含大量的时间用于社交、观众和小组讨论。这些将导致激烈的互动。演讲者将被明确要求在演讲期间回答一系列问题，以促进数据驱动、多学科和有针对性的想法的产生，探索缺血性中风作为与其他疾病实体相关的全身性疾病，并更好地解决大脑的进化问题受伤。重点主题包括：(i) 神经血管单元及其损伤； (ii) 目前使用或正在开发的用于治疗急性中风的溶栓剂的安全性和有效性； (iii) 对半影的新看法； (iv) 时间窗口考虑因素和优化的交付条件； (v) 稳定脑组织以促进患者康复； (vi) 增强纤溶酶原激活剂的安全性； (vii) 影响风险和收益的因素； (viii) 替代方法。我们预计脑血管疾病领域内外的广泛参与（250-300 名与会者），从基础研究到临床环境。将从提交的摘要中选出的海报和简短演示纳入议程，以及提供折扣注册价格和旅行奖学金将鼓励少数族裔和年轻研究人员的参与。该系列之前在美国举行的会议分别在拉霍亚（1992 年）和贝塞斯达（1998 年）举行，分别由斯克里普斯诊所和研究基金会以及 NINDS/辛辛那提大学主办。鉴于这些活动的成功、及时且相关的主题以及我们的组织者和顾问的科学严谨性，我们预计会有大量的人见证这些现场和持久的讨论，这将促进跨学科合作，以促进改善治疗管理、新研究缺血性中风急性治疗的想法和方向以及未来指南。 公共健康相关性：在纽约科学院举行的为期三天的科学会议将为脑血管疾病和相关疾病领域的临床医生和科学家、专家提供一个中立的论坛，以产生挑衅性和前瞻性的讨论，以更好地阐明临床和基础科学可以在未来十到十五年推进血流恢复治疗和医疗支持，以促进和改善缺血性中风的急性治疗。该项目的跨学科讨论将把缺血性中风视为一种全身性疾病，认识到高血压、糖尿病和衰老疾病的贡献，超越从症状出现到更深入了解基本机制和先进科学临床试验的时间的传统目标。该论坛还将产生持久的印刷和在线出版物，以突出这些讨论，并将其提供给全球科学界和公众，促进跨学科对话与合作，并促进对中风患者未来医疗护理的关注。 1