MODULATION OF PD-1 EXPRESSION ON T CELLS IN SIV-INFECTED MACAQUES

SIV 感染的猕猴 T 细胞上 PD-1 表达的调节

• 批准号: 8172859
• 负责人: R. PAUL JOHNSON
• 金额: $ 20.24万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8172859
• 关键词: CD28 Antigens; Cells; Computer Retrieval of Information on Scientific Projects Database; Funding; Grant; Institution; Macaca; Manuscripts; Publishing; Research; Research Personnel; Resources; Source; T-Lymphocyte; United States National Institutes of Health; exhaust; research study

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Experiments conducted over the past year have demonstrated that analysis of the costimulatory molecule CD28 in conjunction with PD-1 provides a more accurate definition of exhausted T cells; exhausted cells are PD-1-positive and CD28negative, while activated but functional T cells are PD-1-positive and CD28positive. A manuscript describing these findings has been published.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 在过去的一年中进行的实验表明，对共刺激分子CD28与PD-1结合进行的分析提供了对耗尽的T细胞的更准确定义。耗尽的细胞是PD-1阳性和CD28NENGATIVE，而活化但功能性T细胞是PD-1阳性和CD28阳性的。 描述这些发现的手稿已发表。