SWIFT DETECTION OF SPIO LABELED STEM CELLS GRAFTED IN THE MYOCARDIUM

快速检测移植到心肌中的 SPIO 标记干细胞

• 批准号: 8170460
• 负责人: MICHAEL GARWOOD
• 金额: $ 2.57万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8170460
• 关键词: Anatomy; Cells; Computer Retrieval of Information on Scientific Projects Database; Detection; Dose; Funding; Grant; Heart; Image; Institution; Label; Methods; Myocardium; Research; Research Personnel; Resources; Source; Stem cells; United States National Institutes of Health; base; heart imaging; iron oxide; particle

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The aim of this project is to develop method based on SWIFT for detection of superparamagnetic iron oxide (SPIO) particle-labeled stem cells in biologically relevant doses in the heart. The preliminary ex- vivo imaging of the heart reveals that SWIFT imaginary images present the off-resonant spins as an enhanced (positive) boundary surrounding the region of SPIO-labeled cells while the on-resonant spins are not visible. SWIFT magnitude images provide myocardium anatomies thus eliminating the need for a separate reference image. Such feature of SWIFT facilitates the detection of stem cells compared to the GRE method.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 该项目的目的是基于Swift在心脏中生物学相关剂量中的超顺磁铁（SPIO）颗粒标记的干细胞开发方法。心脏的初步演出成像表明，迅速虚构的图像呈现非谐振的旋转作为围绕Spio标记的细胞区域的增强（正）边界，而在抗谐振的旋转则看不到。迅速的幅度图像提供心肌解剖，从而消除了对单独的参考图像的需求。与GRE方法相比，Swift的这种特征促进了干细胞的检测。