Imaging Brain Function in Real World Environments & Populations with Portable MRI

真实世界环境中的大脑功能成像

基本信息

批准号：
8822705
负责人：
MICHAEL GARWOOD
金额：
$ 39.38万
依托单位：
UNIVERSITY OF MINNESOTA
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-09-26 至 2017-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8822705
关键词：
Applications Grants Behavior Behavioral Bicycling Binding Brain Brain imaging Clinic Cognitive Confined Spaces Developing Countries Discipline Disease Elderly Elements Emergency Situation Energy Supply Engineering Environment Equipment Feasibility Studies Frequencies Functional Magnetic Resonance Imaging Funding Generations Goals Head Helium High Prevalence High temperature of physical object Hospitals Human Image Imaging technology Implant Industry Institution Investigation Laboratories Liquid substance Location Magnetic Resonance Imaging Maintenance Mathematics Mechanics Methodology Methods Motion Movement Natural Disasters Neuroanatomy Neurologic Neurosciences Neurosciences Research New Territories Nitrogen Performance Phase Physics Play Population Population Heterogeneity Population Study Power Sources Process Reporting Research Infrastructure Role Sampling Shoulder Site Social Interaction Soldier Specific qualifier value Sports Students System Techniques Technology Temperature Testing Time Traumatic Brain Injury Tube Variant Veterans War Work base computer science cost design disability experience human subject imaging modality magnetic field meetings multidisciplinary neuroimaging new technology novel portability prevent public health relevance spatiotemporal volunteer

项目摘要

DESCRIPTION (provided by applicant): Functional magnetic resonance imaging (fMRI) continues to play a critical role in understanding the human brain. Yet current fMRI technology is far less than ideal for studying brain function due to the unnatural environment and restricting space of the magnet bore. Furthermore, fMRI cannot be performed on subjects who have metallic implants in their body (e.g., the elderly, soldiers and veterans), or who are impaired by certain physical disabilities as occurs in a variety of neurological and vestibular disorders. Finally, due to its expense and infrastructure requirements, MRI's predominant accessibility to wealthier institutions has resulted in a highly biased subject sampling and a shortage of studies in non-western environments and cultures. The general methodology used to obtain MR images today is essentially the same as that used approximately 4 decades ago. One major drawback of such methodology is that the tolerated magnetic field variation over the brain is limited to a small fraction of the magnet's field, B0. To overcome these limitations, a new MRI methodology has been conceived called STEREO, which stands for steering resonance over the object. By generating images with spatiotemporal-encoding, STEREO allows the B0 field to vary by a large amount, and for the first time, makes it possible to use a smaller, inherently less homogeneous magnet. In this project, the unique capabilities of STEREO will be exploited to demonstrate the feasibility of a portable, remotely supportable, head-only MRI scanner to permit imaging brain function in all populations and environments worldwide. To achieve this goal, this project will develop the STEREO methodology, in combination with new multi-coil gradient technology and new MRI spectrometer technology, to produce human brain images in a highly non-uniform B0. This project will also undertake a feasibility study of a new 1.5 T, high temperature superconducting magnet operating at liquid nitrogen temperature (77 K), to free the requirements for often unavailable liquid helium and/or a stable power supply for cryo-cooling. The overall objective of this grant proposal is to demonstrate the feasibility of critical new methods and technology required for this revolutionary MRI system to become a reality. A multidisciplinary team of leading experts from multiple institutions and industry will meet monthly to report and discuss progress, provide guidance, identify problems and decide corrective courses of action. Based on the experience gained in the process, our new generation MRI system will be specified and designed by the end of this 3-year project. This system will be built and tested with our next round of funding. Making this system available to neuroscientists will open exciting new territories of investigation into the human brain and human behavior, in a wide range of conditions and populations of subjects worldwide.

描述（通过应用程序证明）：功能性磁共振成像（fMRI）在理解人的大脑中继续起着关键作用。钻孔无法在某些身体上播放的物体上的金属植入物，士兵和退伍军人的身分，因为在各种神经系统和鉴别性疾病中，MRI占主导地位，MRI占主导地位。财富记录导致了高度偏见的采样，并且在非西方环境和文化中的研究短缺。大脑上的磁场变化仅限于磁铁场的一部分，以克服局限性，新的MRI方法称为“立体声”，该方法代表了对物体的转向。时间，使使用较小的，固有的较少磁性磁铁。在高度不均匀的B0中，多型梯度技术和新的MRI图像。不可用的液体氦气/或者供应冷却的整体目标。为了报告和讨论进度，提供指导，确定问题并确定纠正措施，我们的新一代MRI系统将由我们的三年项目结束并设计。下一轮资金。