VOLTAGE-GATING MECHANISM OF POTASSIUM CHANNELS

钾通道的电压门控机制

• 批准号: 8172045
• 负责人: FATEMEH KHALILI-ARAGHI
• 金额: $ 5.02万
• 依托单位: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8172045
• 关键词: Animals; Ataxia; Calcium Channel; Cardiac; Cardiovascular Diseases; Cations; Cell membrane; Cells; Computer Retrieval of Information on Scientific Projects Database; Endocrine; Funding; Grant; Human; Institution; Insulin; Integral Membrane Protein; Ions; Life; Long QT Syndrome; Muscle Cells; Nervous system structure; Neurologic; Neurons; Play; Potassium; Potassium Channel; Regulation; Research; Research Personnel; Resources; Role; Signal Transduction; Sodium Channel; Source; United States National Institutes of Health; Work; electrical potential; response; voltage

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Voltage-gated potassium (Kv) channels (http://www.ks.uiuc.edu/Research/kvchannel/) are integral membrane proteins present in all three domains of life. In a specialized class of animal cell, known as excitable cells - including neurons, muscle cells, and endocrine cells - Kv channels work with other cation channels (sodium and calcium channels) to regulate the electrical activity and signaling of the cell [1]. Kv channels activate (open and close) in response to changes in the electrical potential across the cell membrane allowing passive and selective conduction of K+ ions through the channel. Potassium conduction is directed by the electrochemical gradient across the cell membrane and can achieve very high rates, while still discriminating against all other cations (including the smaller Na+ ions) [1]. In addition to electrical signaling in nervous systems, Kv channels play an important role in the regulation of cardiac excitability and regulation of insulin release. In humans, malfunction of these channels can result in neurological or cardiovascular diseases such as long QT syndrome or episodic ataxia [2].

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 电压门控钾 (Kv) 通道 (http://www.ks.uiuc.edu/Research/kvchannel/) 是存在于生命所有三个领域的整合膜蛋白。在专门的 一类动物细胞，称为可兴奋细胞 - 包括神经元、肌肉细胞和 内分泌细胞 - Kv 通道与其他阳离子通道（钠和钙）一起工作 通道）来调节细胞的电活动和信号传导[1]。 Kv通道 激活（打开和关闭）以响应跨接电位的变化 细胞膜允许 K+ 离子被动和选择性地传导通过 渠道。钾传导是由电化学梯度引导的 细胞膜，可以达到非常高的速率，同时仍然歧视 所有其他阳离子（包括较小的 Na+ 离子）[1]。除了电气信号之外 在神经系统中，Kv通道起着重要的调节作用 心脏兴奋性和胰岛素释放的调节。在人类中， 这些通道可能导致神经或心血管疾病，例如 QT 间期延长 综合征或阵发性共济失调[2]。