HEMISPERIC: SPECIALIZATION AND INTERACTION

半球：专业化和互动

• 批准号: 8171040
• 负责人: ERAN ZAIDEL
• 金额: $ 0.3万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8171040
• 关键词: Address; Attention; Behavior; Behavioral; Behavioral Paradigm; Brain; Cerebral Dominance; Cerebrum; Clinical; Cognitive; Communication; Complex; Computer Retrieval of Information on Scientific Projects Database; Corpus Callosum; Data; Funding; Grant; Hand; Individual Differences; Institution; Laboratories; Lesion; Letters; Measures; Methodology; Natural Language Processing; Patients; Perception; Phonetics; Physiological; Process; Reaction Time; Research; Research Personnel; Resources; Role; Source; Structure; Techniques; United States National Institutes of Health; behavior measurement; cognitive neuroscience; design; language perception; parallel processing; programs; research study; theories

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This proposal is part of a research program that aims to clarify (1) hemispheric specialization and independence, (2) interhemispheric interaction, and (3) interhemispheric control. These mechanisms of interhemispheric relations address three central theoretical concepts in cognitive neuroscience: modularity of processing, intermodular communication, and control of parallel modular processes. A core set of progressively complex lateralized behavioral paradigms developed in our laboratory have been designed to (1) explore individual differences in hemispheric specialization in attention, perception and language; (2) contrast different degrees of hemispheric independence, including independence strategies, resources and priming, and (3) analyze the control of parallel processing in the two hemispheres. These experiments range from sensorimotor integration in simple reaction time through phonetic perception and letter identification to complex word recognition. Each experimental paradi gm includes an intrahemispheric component for studying hemispheric independence, and an interhemispheric component for studying interhemispheric interaction and control. These experiments have been administered to normal subjects and to patients with complete cerebral commissurotomy, agenesis of the corpus callosum and patients with partial callosotomy both pre- and post surgically as well as with patients with selected lateralized lesions to examine the role of the right hemisphere in natural language processing. This proposal focuses on the study of the anatomical correlates with some of the same above mentioned behavioral measures of interhemispheric relations. With this approach we combine sophisticated cognitive theory and methodology on the one hand, with in-depth neuroscientific analysis that incorporates anatomical, physiological and clinical behavioral techniques, data and theory on the other. Thus, we use converging studies of normal subjects and parallel measures of brain structure (MRI), brain function, and behavior.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 该提案是一项研究计划的一部分，旨在澄清（1）半球专业化和独立性，（2）半球间相互作用，以及（3）半球间控制。这些半球关系的这些机制介绍了认知神经科学中的三个中心理论概念：处理，管间通信的模块化和平行模块化过程的控制。在我们的实验室中开发的一组逐渐复杂的横向行为范式旨在（1）探索注意力，感知和语言的半球专业化的个体差异； （2）对比度不同的半球独立性，包括独立性策略，资源和启动，以及（3）分析两个半球平行处理的控制。这些实验范围从简单反应时间中的感觉运动整合到语音感知和字母识别到复杂的单词识别。每个实验性范式GM都包括用于研究半球独立性的半球内成分，以及用于研究半球间相互作用和对照的半球间成分。这些实验已针对正常受试者和完全脑部术术，call体的患者以及手术前后的部分call骨切开术的患者以及患有部分横向病变的患者，以及检查右半球在自然语言处理中的作用的患者。该提案的重点是对解剖学的研究，与上述一定程度上的某些相同的行为措施相关。通过这种方法，我们一方面将复杂的认知理论和方法结合在一起，并结合了深入的神经科学分析，其中包含了解剖学，生理和临床行为技术，数据和另一方面。因此，我们使用正常受试者的融合研究以及大脑结构（MRI），大脑功能和行为的平行度量。