HISTONE METHYLATION AND EPIGENETIC CONTROL OF THE GENOME

组蛋白甲基化和基因组的表观遗传控制

• 批准号: 8171330
• 负责人: Songtao Jia
• 金额: $ 0.47万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8171330
• 关键词: Chromosomes; Complex; Computer Retrieval of Information on Scientific Projects Database; Enzymes; Epigenetic Process; Fission Yeast; Funding; Genome; Grant; Histones; Institution; Methylation; Modification; Proteins; Research; Research Personnel; Resources; Source; United States National Institutes of Health; histone methyltransferase; methyl group; novel

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Residue specific methylation of histones results in diverse epigenetic states. But how histone methyltransferases (enzymes that add methyl group to histones) and histone demethylases (enzymes that remove methyl group from histones) are targeted to specific chromosome domains are not well understood. More importantly, apart from several well-known examples, how the cellular machinery recognizes these modifications is not clear. We will purify histone methyltransferase and demethylases complexes from fission yeast to identify novel proteins that regulate histone methylation.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 中心，不一定是研究者的机构。 组蛋白的残基特异性甲基化导致不同的表观遗传状态。但组蛋白如何 甲基转移酶（向组蛋白添加甲基的酶）和组蛋白去甲基酶 （从组蛋白中去除甲基的酶）针对特定染色体 域没有被很好地理解。更重要的是，除了几家知名的 例如，细胞机制如何识别这些修饰尚不清楚。我们将 从裂殖酵母中纯化组蛋白甲基转移酶和去甲基酶复合物以鉴定 调节组蛋白甲基化的新蛋白质。