DYNAMICS AND CEREBRAL SOURCES OF ATTENTIONAL PROCESSES

注意过程的动力学和大脑来源

• 批准号: 8171153
• 负责人: GREGORY V SIMPSON
• 金额: $ 0.61万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8171153
• 关键词: Area; Attention; Brain; Brain region; Cerebrum; Computer Retrieval of Information on Scientific Projects Database; Data; Electroencephalography; Electromagnetics; Functional Magnetic Resonance Imaging; Funding; Grant; Institution; Investigation; Laboratories; Location; Magnetic Resonance Imaging; Magnetoencephalography; Methods; Nature; Pattern; Process; Research; Research Personnel; Resources; Source; Spatial Distribution; System; United States National Institutes of Health; improved; information processing; interdisciplinary approach; neuroimaging

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We consider attention to be a construct which includes three interrelated classes of dynamic precesses: 1) those involved in redirecting attention, 2) those which selectively process information according to the focus of attention, and 3) those which are involved in sustaining the focus of attention. Due to the dynamic nature of these processes, investigation of the underlying brain mechanisms requires analyses of the active brain regions and their temporal activation patterns. Through our progress in the preceding grant period and through collaborative projects, we have the ability to acquire electroencephalography (EEG), magnetoencephalography (MEG), brain anatomical magnetic resonance images (MRI) and functional MRI (fMRI); as well as the capability to integrate and analyze these multi-modal data in our laboratory. This has enabled us to improve our methods for electromagnetic source estimation (EMSE) of the brain sources of EEG and MEG, including characterization of the temporal activation patterns in these brain areas. We now have the ability to constrain the EMSE with anatomical MRI and to inform the locations of likely brain sources with fMRI data in the same subjects. fMRI also serves as a stand-alone functional neuroimaging method for exploring the brain systems involved in attention. The proposed project applies this integrated multidisciplinary approach to examination of the spatial distribution of brain areas involved in these attentional processes and characterization of the temporal dynamics of the brain systems involved.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 我们将注意力视为一种包括三个相互关联的动态进攻类别的构造：1）参与重定向注意力的人，2）那些根据注意力的焦点选择性地处理信息的人，以及3）参与维持注意力重点的信息。由于这些过程的动态性质，对潜在大脑机制的研究需要分析活性大脑区域及其时间激活模式。通过我们在上一期授予期内的进步和通过协作项目，我们有能力获得脑电图（EEG），磁脑电图（MEG），大脑解剖学磁共振图像（MRI）和功能性MRI（fMRI）；以及在我们的实验室中整合和分析这些多模式数据的能力。这使我们能够改善脑电图和MEG大脑源的电磁源估计方法（EMSE）的方法，包括表征这些大脑区域中时间激活模式的表征。现在，我们可以通过解剖学MRI来限制EMSE，并在同一受试者中使用fMRI数据来告知可能的大脑源位置。 fMRI也是一种独立的功能神经影像学方法，用于探索参与注意力的大脑系统。拟议的项目将这种综合的多学科方法应用于检查这些注意力过程中涉及的大脑区域的空间分布以及所涉及大脑系统的时间动态的表征。