Neurophysiological Attention Test (NAT) for Objective Assessment of ADHD

用于客观评估 ADHD 的神经生理学注意力测试 (NAT)

• 批准号: 9335457
• 负责人: GREGORY V SIMPSON
• 金额: $ 75万
• 依托单位: THINK NOW, INC.
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-04-03 至 2020-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9335457
• 关键词: Adult; Assessment tool; Attention; Attention deficit hyperactivity disorder; Base of the Brain; Behavioral; Biological Markers; Brain; Classification; Clinical Research; Clinical Trials; Collaborations; Computer software; Controlled Clinical Trials; Data Analyses; Data Quality; Data Set; Device or Instrument Development; Devices; Diagnosis; Diagnostic; Disease; Electrodes; Electroencephalography; Environment; Evaluation; Functional Magnetic Resonance Imaging; Future; Goals; Impulsivity; Individual; Lead; Legal patent; Location; Maintenance; Measures; Methods; Modeling; Modification; Monitor; National Institute of Mental Health; Neurosciences; Performance; Phase; Pilot Projects; Preparation; Prevalence; Process; Research; Research Domain Criteria; Research Personnel; Running; Sample Size; Scalp structure; Series; Signal Transduction; Site; Source; Stimulus; Structure; Syndrome; System; Testing; Validation; Visual evoked cortical potential; Wireless Technology; Work; attentional control; base; behavior measurement; brain dysfunction; cognitive control; computerized data processing; cost; design; disorder control; improved; inattention; indexing; innovation; instrument; laptop; neurophysiology; novel; product development; public health relevance; sensor; sustained attention

 DESCRIPTION (provided by applicant): This project aims to validate a novel neurophysiological assessment tool for Attention-Deficit/Hyperactivity Disorder (ADHD). Adult ADHD is prevalent and enduring and the objective methods for assessment of the disorder are limited, particularly based on functional neurophysiological indices that can also be made readily and inexpensively accessible to a wide market. An important aspect of ADHD would appear to be difficulty in the maintenance of attentional control over periods of 10s of seconds, manifesting as inconsistent within-individual performance on sustained attention tasks with periods of normal performance and other periods of poor performance. We have created an innovative assessment tool, the Neurophysiological Attention Test (NAT), that tracks sustained attention based on electroencephalography (EEG). The NAT provides critical new measures of the fluctuations in control. Unlike any other behavioral or EEG-based assessment tools, the NAT enables continuous tracking of infra-slow fluctuations (ISFs) in neurophysiological indices of BOTH attending targets and ignoring distractors simultaneously, two core components of attention control, during sustained attention tasks (patent pending). Phase-I results show that the NAT identifies both behavioral and EEG indicators that successfully discriminate individuals with ADHD from healthy comparison individuals, and that correlate with scores on rating scales widely used to characterize the inattentive and impulsive features of ADHD. The proposed Phase II project will extend our work from Phase I to further improve the stimulus parameters, optimize the EEG measures for differentiating adults with ADHD from controls, test these improvements in a larger clinical trial (120 subjects per group) conducted across three sites to expand the sample size and verify utility under different recording conditions, and will determine the minimal number of EEG sensors needed for further development of the device. Ultimately, it is expected that the NAT will be an inexpensive, easy to use, easy to distribute, EEG-based objective assessment instrument that provides behavioral measures and functional neurophysiological biomarkers for ADHD. Future uses of the NAT include informing diagnosis, monitoring treatment, evaluating new treatments, and clinical research on the brain mechanisms of ADHD that may lead to better brain-based models and treatment options.

 描述（由适用提供）：该项目旨在验证一种新型的神经生理评估工具，以实现注意力缺陷/多动症障碍（ADHD）。成人多动症是普遍且持久的，评估该疾病的客观方法受到限制，尤其是基于功能性神经生理学指数，这些指数也可以轻松地在广泛的市场上易于访​​问。在维持10秒的时间时，ADHD的一个重要方面似乎很困难，这表现为在持续的注意力任务上表现出不一致的内部表现，并且具有正常性能和其他表现不佳时期。我们创建了一个创新的评估工具，即神经生理注意测试（NAT），该工具跟踪基于脑电图（EEG）的持续关注。 NAT为控制中波动提供了关键的新措施。与任何其他基于行为或基于脑电图的评估工具不同，NAT可以连续跟踪参加目标的神经生理学指数中的红外波动（ISF）（ISF），并且在持续的注意任务（持续的待定）期间，参与目标的两个核心组成部分，注意力控制的两个核心组成部分。第1阶段的结果表明，NAT识别行为和脑电图指标，这些指标成功地将ADHD的个体与健康的比较个体区分开来，并且与评级量表的分数相关，以广泛用来表征ADHD的不专心和冲动性特征。拟议的II期项目将从第一阶段扩展我们的工作，以进一步改善刺激参数，以优化对控制的成年人区分成年人的EEG测量值，在跨三个地点进行的较大临床试验（每组120名受试者）中测试这些改进，以扩大样本尺寸的扩展，并在不同的记录条件下进行验证，并确定eeg Sensers of Eeg Senseors of Eeg Senseors的设备。最终，预计NAT将是一种廉价，易于使用，易于分发的基于脑电图的客观评估工具，可为ADHD提供行为测量和功能性神经生理生物标志物。 NAT的未来用途包括告知诊断，监测治疗，评估新治疗方法以及有关ADHD大脑机制的临床研究，这可能会导致更好的基于大脑的模型和治疗选择。