MORPHOSTRUCTURAL CEREBRAL FEATURES ASSOCIATED TO BORDERLINE AND

与边缘和相关的大脑形态结构特征

• 批准号: 8171145
• 负责人: ROBERTA ROSSI
• 金额: $ 0.3万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8171145
• 关键词: Affect; Age; Amygdaloid structure; Area; Auditory; Back; Biological; Bipolar Disorder; Borderline Personality Disorder; Brain; Cerebrum; Clinical; Cognition; Computer Retrieval of Information on Scientific Projects Database; Data; Diagnosis; Diagnostic and Statistical Manual; Education; Emotions; Enrollment; Fright; Funding; General Population; Genetic; Grant; Hippocampus (Brain); Hospitals; Incidence; Institution; Lead; Limbic System; Link; Literature; Maps; Methods; Migraine; Paresthesia; Patients; Pattern; Protocols documentation; Radial; Rage; Reaction; Research; Research Personnel; Resources; Scanning; Source; Structure; Symptoms; Trauma; United States National Institutes of Health; Visual; Weight; experience; neuroimaging; neuropsychological; psychosocial; sex; tool; volunteer

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. "Morphostructural cerebral features associated to borderline and bipolar disorders" Background: Borderline personality disorder (BPD) is prevalent, affecting as many as 1% to 2% of the general population, and this incidence rises as high as 15% to 20% in psychiatric settings. Although psychosocial causes of BPD have been explored in many studies, relatively little data exist regarding biological causes. Use of neuroimaging in the study of BPD dates back only a few years. BPD has been linked to the amygdala and limbic systems of the brain, the centres that control emotion and, particularly, rage, fear and impulsive automatic reactions. Studies have shown that the hippocampus and the amygdala may be as much as 16% smaller in people with BPD and have suggested that experiences of trauma may lead to these neuroanatomical changes. Furthermore, some clinical similarity with Bipolar disorder (BD) and BPD have been described although the results are often contradictory and not exhaustive. Aim: To study morphostructural cerebral features associated to BPD and BP using advanced neuroimaging tools and to assess whether an association between specific cerebral areas/circuits and clinical features exists. Material and methods. We included in the study 25 BDP, 19 BP and 46 controls. Diagnoses will be made according DSM IV criteria. Patients underwent clinical and neuropsychological assessment. All patients will underwent MR. The scan protocol included a 3D T1-weighted sequence and PD/T2-weighted dual echo sequence. Healthy subjects were consecutive normal volunteers picked among those undergoing brain MR scan at the Neuroradiology Unit of the "Poliambulanza" Hospital, Brescia for reasons unrelated to cognition, such as migraine and headache, auditory or visual symptoms, paresthesias, and whose scan was negative and enrolled in a study on normal brain structure . Controls were matched to patients with regard to sex, age and education. Cortical pattern matching will be used to detect and visualize cortical variability due to the effect of CS and genetic factors on the brain. In line with literature we will study hippocampus using radial mapping.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 “与边缘和躁郁症相关的形态结构大脑特征” 背景：边缘性人格障碍（BPD）普遍存在，影响到普通人群的1％至2％，而在精神科环境中，这种发病率上升到高达15％至20％。尽管在许多研究中已经探讨了BPD的社会心理原因，但关于生物学原因的数据相对较少。在BPD研究中使用神经影像学的日期仅几年。 BPD已与大脑的杏仁核和边缘系统，控制情绪，尤其是愤怒，恐惧和冲动自动反应的中心有关。研究表明，BPD患者的海马和杏仁核可能小16％，并建议创伤经历可能导致这些神经解剖学变化。此外，尽管结果通常是矛盾的，且不详尽，但已经描述了与躁郁症（BD）和BPD的一些临床相似性。 目的：研究使用先进的神经影像工具研究与BPD和BP相关的形态结构大脑特征，并评估是否存在特定的脑区域/电路和临床特征之间的关联。 材料和方法。我们包括在研究中25 bdp，19 bp和46个对照组。诊断将根据DSM IV标准进行。患者接受了临床和神经心理学评估。所有患者将接受MR。扫描协议包括3D T1加权序列和PD/T2加权双回波序列。健康受试者是在Brescia的“ Poliambulanza”医院神经放射学部门的脑部MR SCAN中连续选择的正常志愿者，原因是与认知无关的原因，例如偏头痛和头痛，听觉或视觉症状，观念症，视觉性症状，扫描和扫描是负面的，并且在正常的大脑结构中负面研究。对照与性别，年龄和教育有关的患者匹配。由于CS和遗传因素对大脑的影响，皮质模式匹配将用于检测和可视化皮质变异性。与文献一致，我们将使用径向映射研究海马。