HIPPOCAMPAL FORMATION IN PSYCHOPATHY: A RADIAL MAPPING MR-BASED STUDY

精神病中的海马结构：基于 MR 的径向映射研究

• 批准号: 8363442
• 负责人: ROBERTA ROSSI
• 金额: $ 0.51万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8363442
• 关键词: Age; Algorithms; Functional disorder; Funding; Grant; Hippocampal Formation; Hippocampus (Brain); Magnetic Resonance; Maps; Measurement; Measures; Medial; Methods; Modeling; National Center for Research Resources; Neurobiology; Pathology; Principal Investigator; Radial; Research; Research Infrastructure; Resources; Slice; Source; Surface; System; Temporal Lobe; United States National Institutes of Health; Violence; base; computational anatomy; cost; in vivo; men; psychopathic behavior; psychopathic personality; regional difference; relating to nervous system

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. 'Background. Neurobiology of psychopathy remains obscure. Medial temporal lobe pathology has been suggested to be a part of the neural systems dysfunction which manifests as violent and psychopathic behavior. In a previous study, Laakso and colleagues measured regional hippocampal volumes using magnetic resonance and found that the regional volumes along the anteroposterior axis of the hippocampus were correlated with the subjects' degree of psychopathy. Strong negative correlations were observed between the psychopathy scores and the posterior half of the hippocampi bilaterally. Aim. To locate in vivo the structural changes within the hippocampal formation in subjects with psychopathy. Methods. Twenty-six men with psychopathy (age:32¿8) and 25 controls (35¿11) were included in this study. Psychoapthy were assessed using the Psychopathy Checklist-Revised. The hippocampal formation will be isolated by manually tracing on 35 coronal slices the outlines of the hippocampus proper and subiculum after registration to a common stereotactic space. Group differences will be assessed with algorithms developed ad hoc that make use of three-dimensional parametric surface mesh models. Expected results. We expect that regional differences within the hippocampal formation should exist between psychopathy and controls and should be in line with previous results obtained with volumetric measurements (Laakso et al, 2001).

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 '背景。精神病的神经生物学仍然晦涩难懂。媒体暂时的叶病理学被认为是神经系统功能障碍的一部分，表现为暴力和精神病行为。在先前的研究中，Laakso及其同事使用磁共振测量了区域海马体积，发现沿海马前轴沿前后轴的区域体积与受试者的精神病程度相关。双侧的精神病评分和海马后半部分之间观察到了强的负相关。 目的。在体内定位心理病受试者海马形成中的结构变化。 方法。这项研究包括26名精神病患者（年龄：32¿8）和25个对照（35¿11）。使用精神病清单​​重新定义的心理局部评估。海马形成将通过手动追踪在35个冠状切片上，在注册到公共立体定向空间后，在35个冠状切片上符合海马的轮廓和地下。将通过开发的临时算法来评估组差异，该算法使用三维参数表面网格模型。 预期结果。我们预计，在精神病和对照之间应该存在海马形成中的区域差异，并且应与以前通过体积测量获得的结果一致（Laakso等，2001）。