DEVELOPING A PUBLIC CRYOEM REPOSITORY DATABASE

开发公共 CryOEM 存储库数据库

• 批准号: 8168546
• 负责人: Helen M Berman
• 金额: $ 2.15万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-01-15 至 2010-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8168546
• 关键词: Archives; Biological Models; Collection; Communities; Computer Retrieval of Information on Scientific Projects Database; Cryoelectron Microscopy; Data; Databases; Deposition; Educational workshop; Electron Microscopy; Funding; Goals; Grant; Image; Imagery; Institution; Maps; Metadata; Modeling; Proteins; Research; Research Personnel; Resources; Source; System; United States National Institutes of Health; Validation; base; density; reconstruction; repository; research study; structural biology; tool

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Our goal is to create a robust system for the collection, validation, annotation, distribution and visualization of data derived from cryoEM experiments and analyses. We will provide researchers with an integrated "one-stop shop" for the deposition and assessment of metadata, maps, and models, as well as a comprehensive and quantitative description of the deposited data and its linkage to other relevant databases for end-users. We are building on and significantly enhancing the systems currently operated by the wwPDB for the deposition and distribution of 3D atomic models, and the systems at the EBI for the deposition and distribution of electron microscopy based reconstruction maps. The end result will be the full integration of cryoEM experimental data into the PDB archive as managed by the Worldwide Protein Data Bank (wwPDB, http://wwpdb.org). In addition, the investigators at the National Center for Macromolecular Imaging in Houston will also develop the necessary computational and visualization tools so that the cryoEM researchers can use them to validate the maps and models, and the archived density maps and models can be easily viewed by the public. Through this establishment, we continuously seek the advice from the various experts in the cryoEM and structural biology community through workshops.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 我们的目标是创建一个强大的系统，用于收集、验证、注释、分发和可视化来自冷冻电镜实验和分析的数据。我们将为研究人员提供一个集成的“一站式服务”，用于元数据、地图和模型的存储和评估，以及对存储数据及其与最终用户其他相关数据库的链接的全面和定量描述。我们正在建立并显着增强 wwPDB 目前运行的用于沉积和分布 3D 原子模型的系统，以及 EBI 用于沉积和分布基于电子显微镜的重建图的系统。最终结果是将冷冻电镜实验数据完全整合到由全球蛋白质数据库（wwPDB，http://wwpdb.org）管理的 PDB 档案中。此外，休斯敦国家高分子成像中心的研究人员还将开发必要的计算和可视化工具，以便冷冻电镜研究人员可以使用它们来验证图和模型，并且可以轻松查看存档的密度图和模型。公众。通过这个机构，我们通过研讨会不断寻求冷冻电镜和结构生物学界各专家的建议。