STRUCTURAL BASIS OF CELL MEMBRANE TARGETING, ADHESION, AND SIGNALING

细胞膜靶向、粘附和信号传导的结构基础

• 批准号: 8170160
• 负责人: William I Weis
• 金额: $ 0.03万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8170160
• 关键词: Actins; Adhesions; Allosteric Regulation; Binding; Cadherins; Cell Adhesion; Cell membrane; Complex; Computer Retrieval of Information on Scientific Projects Database; Couples; Cytoskeleton; F-actin-binding proteins; Funding; Grant; Institution; Length; Regulation; Research; Research Personnel; Resources; SNAP receptor; Signal Transduction; Source; Specificity; Structure; United States National Institutes of Health; base; mutant; programs; protein structure; synchrotron radiation; syntaxin

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This program aims to determine the structures of proteins involved in cell membrane targeting, adhesion, and signaling, in order to establish the mechanism and specificity of their interactions. There are currently two projects with crystals that require synchrotron radiation. 1. Structure of full-length a-catenin, an F-actin binding protein that couples cadherin-based cell adhesion to regulation of the actin cytoskeleton. 2. Complexes of the SNARE regulator Munc18a bound to mutants of the SNARE syntaxin that will allow understanding of allosteric regulation of this interaction.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此，可以在其他清晰的条目中表示。列出的机构是 对于中心，这不一定是调查员的机构。 该程序旨在确定与细胞膜靶向，粘附和信号传导有关的蛋白质的结构，以建立其相互作用的机制和特异性。 当前有两个具有晶体需要同步辐射的项目。 1。全长A-catenin的结构，一种F-肌动蛋白结合蛋白，伴侣基于钙粘着蛋白的细胞粘附于肌动蛋白细胞骨架的调节。 2。核心调节剂munc18a的复合物结合到编语法的突变体，这将允许理解这种相互作用的变构调节。