Neuropathology Core D

神经病理学核心 D

• 批准号: 8051775
• 负责人: LAWRENCE A. HANSEN
• 金额: $ 29.2万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8051775
• 关键词: Affect; Age; Alzheimer' s Disease; American; Amyloid; Anterior; Antibodies; Arts; Autopsy; Axonal Transport; Basal Ganglia; Behavior Therapy; Biochemistry; Biological Assay; Brain; Brain Stem; Case Study; Cerebrospinal Fluid; Cessation of life; Clinical; Collaborations; Communities; Consensus; Consultations; Corpus Callosum; DLG4 gene; Data; Databases; Dementia; Diagnosis; Disease; Dot Immunoblotting; Environment; Enzyme-Linked Immunosorbent Assay; Formalin; Fostering; Freezing; Guidelines; Hippocampus (Brain); Inferior; Institutes; Instruction; Interdisciplinary Study; International; Investigation; Lasers; Lead; Left; Lesion by Stage; Lewy Body Disease; Magnetic Resonance Imaging; Microscopy; Mission; Molecular Analysis; Neocortex; Nerve Degeneration; Neurofibrillary Tangles; Neurons; Online Systems; Paraffin; Parietal; Participant; Pathologic; Pathology; Patients; Performance; Pilot Projects; Plasma; Principal Investigator; Process; Production; Protocols documentation; Registries; Relative (related person); Reporting; Research; Research Personnel; Research Project Grants; Resources; Risk; Sampling; Scanning; Staging; Staining method; Stains; Students; Synapses; Synaptophysin; Techniques; Temporal Lobe; Tissues; Training; Ubiquitin; Western Blotting; Writing; alpha synuclein; brain tissue; clinical Diagnosis; genome wide association study; genome-wide analysis; immunocytochemistry; immunoreactivity; innovation; investigator training; meetings; mild neurocognitive impairment; neocortical; neurochemistry; neuropathology; normal aging; programs; protein TDP-43; quality assurance; repository; symposium; syntaxin; tau Proteins; tau-1; thioflavine; tool; web site; working group

The Neuropathology Core has been instrumental in providing support for establishing the accuracy of clinical diagnosis of Alzheimer's Disease (AD) and dementia with Lewy bodies (DLB), delineating structural and clinico-pathological correlates of dementia in AD, identifying new neuropathological entities causing dementia, provide tissues to investigators and helping to better understand the mechanisms of synaptic degeneration in AD. For the renewal the Aims of the Neuropathology Core will be to: 1) perform rapid autopsies and procure brains from the ADRC participants, using a standardized protocol; 2) perform standardized neuropathological diagnoses of demented and normal aged (control) patients clinically evaluated by the UCSD ADRC; 3) perform Braak staging and lesion counts for AD, DLB and fronto-temporal dementia (FTD) cases; 4) maintain a state of the art brain repository to provide the ADRC projects and other investigators with well characterized; 5) perform immunochemical analysis relevant to neurodegeneration and amyloid production in selected ADRC cases and 6) foster the utilization of the ADRC Neuropathology tissue repository for new research and inter-center collaborations. Approximately 40 cases and 20 tissue requests will be processed a year. The neuropathological results will be submitted to the National Alzheimer's Coordinating Committee (NACC) in compliance with NIA requirements. As part of the mission of the Core we will also continue to support extensive collaborations with national and international investigators and train fellows, residents, graduate and undergraduate students in neuropathology and microscopy techniques. We will be provide brain tissues and expert consultation on AD and DLB cases for Project 1, tissues and data relevant to axonal transport pathology in DLB to Project 2, and data on neurodegeneration of selected neuronal regions in DLB cases to Project 3. The Core also contributes significantly to the other Cores and is involved in developing new assays and incorporating new tools for neuropathological analysis including stereology and laser capture microscopy. RELEVANCE (See instructions): AD affects millions of Americans with its risk growing exponentially with age. The AD Centers Program fosters research related to AD and non-AD dementias. The ADRC will enhance the performance of innovative research on AD and related topics, including research that may lead to potential disease modifying therapies or behavioral treatments. It will provide an environment and core resources to enhance research, foster professional and community training, and coordinate interdisciplinary research.

神经病理学核心一直在提供支持临床准确性的支持 诊断为阿尔茨海默氏病（AD）和痴呆症患有路易的身体（DLB），描述结构和 AD中痴呆症的临床病理相关性，确定引起的新神经病理学实体 痴呆，向研究人员提供组织，并有助于更好地了解突触的机制 AD退化。对于续约，神经病理学核心的目的将是：1） 使用标准化协议，从ADRC参与者那里尸检并从ADRC参与者那里获得大脑； 2）执行 临床上痴呆症和正常老年（对照）患者的标准化神经病理学诊断 由UCSD ADRC评估； 3）进行AD，DLB和额叶的BRAAK分期和病变计数 痴呆症（FTD）病例； 4）保持最先进的大脑存储库，以提供ADRC项目和其他 具有良好特征的调查员； 5）进行与神经变性有关的免疫化学分析 在选定的ADRC病例中产生淀粉样蛋白，6）促进了ADRC神经病理学的利用率 新研究和中心合作的组织存储库。大约40例和20个组织 请求将一年处理。神经病理学结果将提交给国家 阿尔茨海默氏症协调委员会（NACC）符合NIA要求。作为任务的一部分 我们还将继续支持与国家和国际的广泛合作的核心 调查人员和火车研究员，居民，毕业生和本科生神经病理学和 显微镜技术。我们将就AD和DLB案例提供脑组织和专家咨询 项目1，与DLB中轴突传输病理相关的项目和数据，以及有关项目2的数据 在项目3的DLB病例中选定的神经元区域的神经变性。核心也有助于 重要的是其他核心，并参与开发新测定和合并新工具 神经病理学分析，包括立体学和激光捕获显微镜。 相关性（请参阅说明）： 广告会影响数百万的美国人，其风险随着年龄的增长而成倍增长。广告中心计划 促进与AD和非AD痴呆有关的研究。 ADRC将提高 关于AD和相关主题的创新研究，包括可能导致潜在疾病的研究 修改疗法或行为疗法。它将提供一个环境和核心资源来增强 研究，培养专业和社区培训，并协调跨学科研究。