Cannabinoid-Altered Vocal Development

大麻素改变声音发育

基本信息

批准号：
7496073
负责人：
KENNETH M SODERSTROM
金额：
$ 27.31万
依托单位：
EAST CAROLINA UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-09-15 至 2011-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7496073
关键词：
Acute Adolescence Adolescent Adult Age Agonist Animals Antibodies Area Auditory Behavioral Brain Brain region Cannabinoids Choline O-Acetyltransferase Chromosome Pairing Chronic Class Communication Condition Consumption Corpus striatum structure Daily Dendritic Spines Dependence Development Dose Down-Regulation Drug Exposure Endocannabinoids Exposure to FOS gene Fiber Golgi Apparatus Human Immunohistochemistry Indium Interneurons Label Late Effects Learning Marijuana Marijuana Abuse Measures Methods Modeling Motor Nature Neurons Numbers Parvalbumins Pattern Perception Pharmaceutical Preparations Physiological Play Population Probability Process Production Prosencephalon Proteins Range Receptor Activation Relative (related person)Reporting Role Sensory Series Signal Transduction Somatostatin Songbirds Staining method Stains Stereotyping Substance P Synapses System Testing Thalamic structure Time Vertebral column Waxes Work addiction cannabinoid receptor day density desensitization design dosage early onset drug abuse improved neural circuit neuromechanism postnatal receptor receptor density receptor expression relating to nervous system research study transcription factor vocal control vocal learning zebra finch

项目摘要

DESCRIPTION (provided by applicant): Early initiation of drug abuse is associated with increased likelihood of later dependence and a decreased probability of quitting in adulthood. These observations are supported by results of animal studies demonstrating that exposure to CNS-active drugs around the time of adolescence causes behavioral changes related to drug consumption that persist to adulthood. We have obtained similar results investigating effects of cannabinoids (drugs that act like marijuana) administered during periadolescence on the vocal development of a songbird, the zebra finch, an animal that learns a form of vocal communication during periods of late-postnatal development. We have found that cannabinoids alter zebra finch vocal development (but not already-learned adult song) and that the neural circuit that regulates this learning process contains a strikingly distinct and dense expression of cannabinoid receptors. Thus, the songbird brain provides a unique model to examine the effects of cannabinoids on neural and behavioral development. This new project will identify physiological changes responsible for cannabinoid-altered vocal learning. Because late-postnatal CMS development is characterized by similar activity-dependent processes of synaptic refinement and fiber tract maturation in both songbirds and mammalian species, what we learn about the neural mechanisms of cannabinoid-altered sensory-motor vocal learning will likely prove relevant to the problem of human marijuana abuse that typically begins during adolescence.

描述（由申请人提供）：早期开始滥用药物与以后依赖的可能性增加以及成年后戒烟的可能性降低相关。这些观察结果得到了动物研究结果的支持，这些研究表明，在青春期左右接触中枢神经系统活性药物会导致与药物消耗相关的行为变化，这种变化会持续到成年。我们在调查青春期服用大麻素（作用类似于大麻的药物）对鸣禽（斑胸草雀）声音发育的影响时获得了类似的结果，斑胸草雀是一种在产后发育后期学习声音交流形式的动物。我们发现大麻素会改变斑胸草雀的声音发育（但不会改变已经学会的成年歌曲），并且调节这一学习过程的神经回路包含大麻素受体的惊人独特和密集的表达。因此，鸣禽大脑提供了一个独特的模型来检查大麻素对神经和行为发育的影响。这个新项目将确定导致大麻素改变声音学习的生理变化。由于鸣禽和哺乳动物的产后 CMS 发育具有类似的突触细化和纤维束成熟的活动依赖性过程，因此我们对大麻素改变的感觉运动发声学习的神经机制的了解可能会证明与人类大麻滥用问题通常始于青春期。