UNMC: MICROARRAY CORE, GENOMICS

UNMC：微阵列核心、基因组学

• 批准号: 8167478
• 负责人: JAMES D EUDY
• 金额: $ 4.89万
• 依托单位: UNIVERSITY OF NEBRASKA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8167478
• 关键词: Binding Sites; Chromosomes; Clinical; Computer Retrieval of Information on Scientific Projects Database; Core Facility; DNA Microarray Chip; DNA-Protein Interaction; Defect; Development; Diagnostic; Epigenetic Process; Funding; Genetic; Genetic Transcription; Genomics; Genotype; Grant; Histone Acetylation; Institution; Investigation; Measurement; Methylation; Microarray Analysis; Monitor; Research; Research Personnel; Research Project Grants; Resources; Source; United States National Institutes of Health; biological research; biological systems; comparative genomic hybridization; genome-wide; tool; transcription factor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The UNMC DNA Microarray Core Facility will support the InBRE project by providing the necessary resources for investigators to utilize DNA microarray technology in their respective research projects. DNA microarray technology is an important tool used in the investigation of biological systems. It is used in a variety of biological research applications including genome-wide transcription measurements, genome-wide genotyping and chromosome copy number measurements (Stoughton, 2005; Todd et al 2007). Microarrays are also used in epigenetic studies to monitor methylation status as well as DNA / protein interactions such as transcription factor binding sites and histone acetylation (Hoheisel, 2006). DNA microarrays have also become a routine diagnostic tool in clinical genetics settings in the context of comparative genomic hybridization (cGH), and are used to identify submicroscopic deletions and amplifications responsible for a variety of developmental defects (Oostlander et al, 2004).

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 UNMC DNA微阵列核心设施将通过为调查人员提供必要的资源来支持INBRE项目，以便研究人员在其各自的研究项目中利用DNA微阵列技术。 DNA微阵列技术是用于研究生物系统的重要工具。它用于多种生物学研究应用中，包括全基因组转录测量，全基因组基因分型和染色体拷贝数测量值（Stoughton，2005; Todd et al 2007）。微阵列也用于表观遗传研究中，以监测甲基化状态以及DNA /蛋白质相互作用，例如转录因子结合位点和组蛋白乙酰化（Hoheisel，2006）。在比较基因组杂交（CGH）的背景下，DNA微阵列也已成为临床遗传学环境中的常规诊断工具，并用于识别负镜下缺失和造成各种发育缺陷的放大（Oostlander等，2004）。