MECP2 POLYMORPHISMS IN SLE

SLE 中的 MECP2 多态性

• 批准号: 8168264
• 负责人: Amr H Sawalha
• 金额: $ 22.81万
• 依托单位: OKLAHOMA MEDICAL RESEARCH FOUNDATION
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8168264
• 关键词: Affect; Biological Assay; Computer Retrieval of Information on Scientific Projects Database; DNA Resequencing; Funding; Genes; Genetic Polymorphism; Grant; Haplotypes; Individual; Institution; Research; Research Personnel; Resources; Risk; Series; Source; United States National Institutes of Health; Variant; case control; chromatin immunoprecipitation; novel; protein complex

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In this study, resequencing will be used to further characterize the MECP2 gene in individuals with the risk and protective haplotypes, searching for novel variants. These variants will then be assayed in an independent series of cases and controls. Additionally, chromatin immunoprecipitation will be used to determine the affects of these variants on DNA/protein complexes.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 在这项研究中，将重新配置用于进一步表征具有风险和保护性单倍型的个体中的MECP2基因，以寻找新型变体。然后将在一系列独立的病例和对照组中分析这些变体。另外，将使用染色质免疫沉淀来确定这些变体对DNA/蛋白质复合物的影响。