MECP2 POLYMORPHISMS IN SLE

SLE 中的 MECP2 多态性

• 批准号: 8359796
• 负责人: Amr H Sawalha
• 金额: $ 13.96万
• 依托单位: OKLAHOMA MEDICAL RESEARCH FOUNDATION
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8359796
• 关键词: Affect; Autoimmunity; Biological Assay; DNA; DNA Resequencing; Funding; Genes; Genetic; Grant; Haplotypes; Individual; Molecular; National Center for Research Resources; Principal Investigator; Research; Research Infrastructure; Resources; Risk; Series; Source; Systemic Lupus Erythematosus; United States National Institutes of Health; Variant; case control; chromatin immunoprecipitation; cost; novel; protein complex

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. In this study, resequencing will be used to further characterize the MECP2 gene in individuals with the risk and protective haplotypes, searching for novel variants. These variants will then be assayed in an independent series of cases and controls. Additionally, chromatin immunoprecipitation will be used to determine the affects of these variants on DNA/protein complexes.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的首席研究员可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 在这项研究中，重测序将用于进一步表征具有风险和保护性单倍型的个体的 MECP2 基因，寻找新的变异。然后将在一系列独立的病例和对照中对这些变异进行分析。此外，染色质免疫沉淀将用于确定这些变异对 DNA/蛋白质复合物的影响。