CLINICAL TRIAL: NON-ALCOHOLIC STEATOHEPATITIS CLINICAL RESEARCH NETWORK

临床试验：非酒精性脂肪性肝炎临床研究网络

• 批准号: 8166794
• 负责人: JOEL Edward LAVINE
• 金额: $ 2.36万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-12-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8166794
• 关键词: Ancillary Study; Clinical; Clinical Research; Clinical Trials; Computer Retrieval of Information on Scientific Projects Database; DNA; Data Collection; Databases; Diagnosis; Etiology; Funding; Grant; Image; Institution; Laboratories; Liver; Liver diseases; Measures; Natural History; Pathogenesis; Patients; Phase; Phase III Clinical Trials; Prevention; Recruitment Activity; Research; Research Personnel; Resources; Serum; Severities; Source; Staging; Subgroup; Therapeutic Studies; Tissue Banking; Tissue Banks; Tissues; United States National Institutes of Health; Urine; cohort; diabetic patient; multidisciplinary; non-alcoholic fatty liver; non-diabetic; nonalcoholic steatohepatitis; novel strategies

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Elucidate, through the cooperative effort of a multidisciplinary and multicenter group of collaborators, the etiology, natural history, diagnosis, treatment and prevention of nonalcoholic fatty liver disease (NAFLD) and in particular its more severe form of NASH and its complications. Construct a database of a large cohort of patients with NAFLD with a broad range of severity, recruited by the network. Core data collection will include clinical, demographic, laboratory, imaging and histological features. Develop a tissue bank comprising serum, liver tissue, DNA and urine obtained from recruited patients. Undertake Phase 2 and 3 trials of new approaches to the therapy of NAFLD in non-diabetic and diabetic patient subgroups. Provide a resource for developing clinical and pathological criteria for standardizing diagnotsic and staging criteria for NAFLD, provide a resource for developing clinical and pathological criteria and best measures and endpoints for therapeutic studies of NAFLD, provide a resource for ancillary studies of the pathogenesis, natural history and treatment of NAFLD, and initiate phase 3 trials of promising therapies for NAFLD.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 通过多学科和多中心合作者的合作，阐明了病因，自然史，诊断，治疗和预防非酒精性脂肪肝病（NAFLD），尤其是其更严重的NASH及其并发症的形式。构建一个由网络招募的大量NAFLD患者的数据库。核心数据收集将包括临床，人口统计学，实验室，成像和组织学特征。开发由招募患者获得的血清，肝组织，DNA和尿液的组织库。在非糖尿病患者亚组中进行NAFLD治疗的新方法的第2阶段和第3阶段试验。为开发NAFLD诊断和分期标准的临床和病理标准提供资源，为开发NAFLD治疗研究的临床和病理学标准以及最佳措施和终点提供了资源，为NAFLD的治疗研究提供了资源，为NAFLD的病原体，自然历史和NAFLD的病原体病理和治疗提供了辅助研究，并为NAFLD的自然治疗以及启发性的naf nef nef nef naf aft aft naf aff separiatiation。