XENOBIOTIC BIOTRANSFORMATION IN CHILDREN WITH NONALCOHOLIC FATTY LIVER DISEASE

非酒精性脂肪肝病儿童的异生生物转化

• 批准号: 8166859
• 负责人: JOEL Edward LAVINE
• 金额: $ 0.24万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-12-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8166859
• 关键词: Acetaminophen; Adolescent; CYP2D6 gene; CYP3A4 gene; Caffeine; Child; Collection; Computer Retrieval of Information on Scientific Projects Database; Cytochrome P-450 CYP1A2; Enzymes; Funding; Grant; Institution; Liver diseases; Metabolic Biotransformation; Metabolism; Phase; Plasma; Population; Research; Research Personnel; Resources; Saliva; Sampling; Source; Transferase; United States National Institutes of Health; Urine; Xenobiotic Metabolism; Xenobiotics; absorption; base; non-alcoholic fatty liver

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The principle objective is to compare the activity of phase I and II enzymes in xenobiotic metabolism in adolescents with or without non-alcoholic fatty liver disease. Specifically, we would compare CYP 1A2, CYP2D6, CYP3A, glucuronyl-transferase (UGT) and sulfono-transferase (ST) activity between these two populations. Other objectives include: To estimate caffeine clearance using a single plasma sample, and CYP 1A2 activity based on urine collection To determine the utility of saliva collection in determining absorption rate of caffeine and acetaminophen To determine the utility of saliva collection in determining acetaminophen metabolism

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 主要目的是比较患有或没有非酒精性脂肪肝疾病的青少年中异种代谢中I和II期酶的活性。具体而言，我们将在这两个种群之间比较CYP 1A2，CYP2D6，CYP3A，CYP3A，CYP3A，葡萄糖酰转移酶（UGT）和磺胺转移酶（ST）活性。 其他目标包括： 使用单个等离子体样品估算咖啡因清除率，以及基于尿液收集的CYP 1A2活性 确定唾液收集在确定咖啡因和对乙酰氨基酚的吸收率中的效用 确定唾液收集在确定对乙酰氨基酚代谢中的效用