Diabetic Kidney Disease: Influence of Exercise on Physical and Vascular Function

糖尿病肾病：运动对​​身体和血管功能的影响

• 批准号: 8141982
• 负责人: Ulf G Bronas
• 金额: $ 13.93万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-15 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8141982
• 关键词: Address; Advisory Committees; Affect; Attenuated; Biological Availability; Biological Markers; Blood Vessels; C-reactive protein; Cardiovascular Diseases; Cardiovascular system; Caring; Chronic Disease; Chronic Kidney Failure; Clinical; Clinical Research; Clinical Trials; Comorbidity; Control Groups; Data; Development Plans; Diabetic Nephropathy; Dialysis procedure; Exercise; Fostering; Functional disorder; General Population; Goals; Guidelines; Health; Healthcare; Hemodialysis; Incidence; Individual; Inflammation; Intervention Studies; Investigation; Kidney; Kidney Diseases; Life; Life Style; Measures; Mediating; Medical; Mentors; Mentorship; Microalbuminuria; Minnesota; Modeling; Morbidity - disease rate; Nitric Oxide; Nitric Oxide Synthase; Non-Insulin-Dependent Diabetes Mellitus; Oxidative Stress; Participant; Patients; Physical Function; Physical activity; Physical therapy exercises; Physiologic pulse; Population; Positioning Attribute; Primary Prevention; Principal Investigator; Randomized; Renal function; Research; Research Personnel; Resources; School Nursing; Secondary Prevention; Stress; Structure; Survival Rate; Testing; Therapeutic; Therapeutic Uses; Time; Training; Training Programs; Universities; Vasodilation; Woman; Work; arterial stiffness; brachial artery; cardiovascular disorder risk; career development; clinical practice; design; dimethylarginine; experience; high risk; improved; inhibitor/antagonist; innovation; insight; isoprostaglandin F2alpha type-III; lifestyle intervention; men; mortality; patient oriented; professor; programs; reactive hyperemia; routine care; sedentary; success

DESCRIPTION (provided by applicant): Dr. Bronas is a Clinical Exercise Physiologist and a Clinical Assistant Professor in the School of Nursing at the University of Minnesota. The purpose of this proposal is to develop Dr. Bronas into an independent clinical researcher with the long-term goal of conducting clinical research using therapeutic lifestyle interventions in the primary and secondary prevention of renal disease related cardiovascular disease. The career development plan consists of a multi-disciplinary approach to foster a translational and inter-disciplinary approach to clinical research. The training program is designed to provide Dr. Bronas with a closely mentored patient-oriented clinical research experience with structured didactics and course work. The primary mentorship will be provided by Drs. Painter and Rosenberg with cardiologists, nephrologists, and clinical trial experts making up the mentoring advisory committee. The objective of the proposed research is to test the hypothesis that a supervised exercise therapy program (n=40) will improve vascular (endothelial) function, arterial structure (stiffness/compliance), and vascular health biomarkers in men and women with pre-dialysis type 2 diabetic kidney disease (DKD), as compared to a usual medical care control group (n=40). This study will further test the hypothesis that a supervised exercise therapy program will improve physical function. This study is investigating an adjunct treatment option (exercise therapy) previously not studied in patients with DKD and which is not a routine part of clinical practice. The proposed study will be the first to investigate the effect of exercise therapy on vascular health factors that are related to the progression of CVD in patients with DKD and if successful, offer a valuable insight into the efficacy of exercise training as an adjunct therapeutic option for patients with DKD. RELEVANCE: This study is significant because it will be the first study to investigate the impact of exercise therapy on vascular health in patients with DKD. This study will increase our understanding of the utility of exercise therapy to improve vascular health in this population, and generate new hypotheses regarding the impact of exercise therapy on factors associated with the progression of CVD in patients with DKD, and thus provide insight into a new and adjunct treatment option.

描述（由申请人提供）：Bronas博士是明尼苏达大学护理学院的临床运动生理学家和临床助理教授。该提案的目的是将野兽博士发展成为一名独立的临床研究人员，其长期目标是在肾脏疾病相关的心血管疾病的初级和二级预防中使用治疗生活方式干预进行临床研究。职业发展计划由一种多学科的方法组成，可以促进一种转化和跨学科的临床研究方法。该培训计划旨在为Bronas博士提供与结构化教学和课程工作有关的密切指导的以患者为导向的临床研究经验。主要的指导将由Drs提供。画家和罗森伯格（Rosenberg）与心脏病专家，肾脏病医生和临床试验专家组成了指导咨询委员会。拟议的研究的目的是检验以下假设：与患有2型糖尿病前糖尿病肾脏病（DKD）的男性和女性相比，男性和女性中男性和女性的血管（内皮）功能，动脉结构（僵硬/合规性）和血管健康生物标志物（与经常的医疗对照组相比）（n = 40）。这项研究将进一步检验以下假设：监督运动治疗计划将改善身体机能。这项研究正在研究以前未在DKD患者中研究的辅助治疗选择（运动疗法），这不是临床实践的常规部分。拟议的研究将是第一个研究运动疗法对DKD患者CVD进展的血管健康因素的影响，如果成功，则可以对运动训练作为DKD患者的辅助治疗选择的有价值的见解。 相关性：这项研究很重要，因为它将是第一个研究运动治疗对DKD患者血管健康的影响的研究。这项研究将提高我们对运动治疗以改善该人群血管健康的实用性的理解，并就运动治疗对DKD患者CVD进展的因素的影响产生新的假设，从而洞悉新的和辅助治疗方案。