Neurophysiological Correlates of Moderate Alcohol Use in Older Adults.

老年人适度饮酒的神经生理学相关性。

• 批准号: 8134209
• 负责人: Jeffrey B Boissoneault
• 金额: $ 3.16万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-29 至 2012-07-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8134209
• 关键词: Accounting; Acute; Adult; Affect; Age; Age-Years; Alcohol consumption; Alcohols; Brain; Cardiovascular system; Consumption; Coronary Arteriosclerosis; Dissociation; Dose; Elderly; Electrophysiology (science); Ethanol; Event; Event-Related Potentials; Female; Gender; General Population; Guidelines; Health; Health Benefit; Human; Impairment; Individual; Intake; Knowledge; Laboratories; Life Style; Literature; Longevity; Measurable; Measurement; Measures; Medical; National Institute on Alcohol Abuse and Alcoholism; Neurocognition; Neurocognitive; Non-Insulin-Dependent Diabetes Mellitus; Performance; Persons; Placebos; Play; Psychomotor Performance; Public Health; Recommendation; Recruitment Activity; Relative (related person); Research; Risk; Risk Reduction Behavior; Role; System; Woman; Work; age group; age related; automobile accident; burden of illness; cancer type; cardiovascular disorder risk; cost; drinking; experience; impaired capacity; improved; interest; male; men; neurophysiology; relating to nervous system; response; sex; social; young adult

DESCRIPTION (provided by applicant): Conventional wisdom and a substantial body of scientific evidence suggests that the intake of small amounts of alcohol confers a variety of health benefits to the user including reduced risk of coronary artery disease, type-2 diabetes, and some types of cancer. Given that this is the case, it is common medical practice to recommend to those individuals who already drink alcohol that they continue to drink, albeit moderately. Although this practice makes intuitive sense, even small acute doses of alcohol have been shown to have subtle, yet measurable effects on neurocognition and psychomotor performance in the user which may confer some risk to that individual. Preliminary evidence from our laboratory suggests the effect of these moderate drinking episodes on psychomotor and neurocognitive performance may differd epending on the individual's age as well as a host of other individual factors. The proposed project extends these preliminary findings through measurement of electrophysiological and psychomotor changes associated with acute moderate drinking and comparing results between two relevant age groups: younger adults (25-40 years of age) and older adults (55- 70 years of age). Although not the primary focus of this proposal, exploratory analyses characterizing potential gender effects will also be conducted. To this end, we intend to recruit equal numbers of men and women for the study.

描述（由申请人提供）：传统观点和大量科学证据表明，摄入少量酒精会给使用者带来多种健康益处，包括降低患冠状动脉疾病、2 型糖尿病和某些类型糖尿病的风险。癌症。鉴于这种情况，常见的医学实践是建议那些已经饮酒的人继续饮酒，尽管适量。尽管这种做法具有直观意义，但即使是小剂量的急性酒精也已被证明会对使用者的神经认知和精神运动表现产生微妙但可测量的影响，这可能会给个人带来一些风险。我们实验室的初步证据表明，这些适度饮酒事件对精神运动和神经认知表现的影响可能会有所不同，具体取决于个人的年龄以及许多其他个人因素。拟议的项目通过测量与急性中度饮酒相关的电生理和精神运动变化并比较两个相关年龄组：年轻人（25​​-40 岁）和老年人（55-70 岁）之间的结果来扩展这些初步发现。虽然不是该提案的主要重点，但还将进行探索性分析，描述潜在的性别影响。为此，我们打算招募同等数量的男性和女性参与这项研究。