Project 1: Urban Dietary Effects on the Asthmatic Response to Pollutants

项目1：城市饮食对污染物哮喘反应的影响

• 批准号: 8185157
• 负责人: GREGORY B DIETTE
• 金额: $ 17.82万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8185157
• 关键词: Address; African American; Age; Air Pollutants; Allergens; Animal Model; Animals; Area; Asthma; Baltimore; Blood; Breathing; Child; Childhood Asthma; Collection; Complement; Complex; Diet; Diet Modification; Dietary Intervention; Dietary Practices; Dietary intake; Disease; Dust; Enabling Factors; Environment; Exhalation; Food; Gases; Home environment; Inflammatory; Irrigation; Lead; Left; Life; Low income; Measurement; Meat; Minority; Modification; Monitor; Morbidity - disease rate; Mus; Neighborhoods; Nitric Oxide; Nitrogen Dioxide; Nose; Oxidative Stress; Participant; Particulate Matter; Pathway interactions; Pattern; Pollution; Population; Predisposition; Recommendation; Recruitment Activity; Research; Research Infrastructure; Research Personnel; Role; Urine; Vulnerable Populations; air monitoring; airborne allergen; base; clinical effect; drinking; experience; fruits and vegetables; health disparity; high risk; human subject; improved; inflammatory marker; inner city; nutritional guideline; particle; pollutant; respiratory; response; suburb

Asthma is a common and complex disorder. In the U.S., the burden of asthma is enormous, with a disproportionate impact on vulnerable groups including young children, African-Americans and those living in the inner city. These most vulnerable people often inhabit an environment that has excessive pollution levels, including high levels of indoor pollutants and allergens. Furthermore, the diet of low-income, inner city African-Americans is markedly inconsistent with national nutritional guidelines, and has a pattern that may leave them especially vulnerable to the effects of inhaled pollutants and allergens. To address the critical questions of the role of dietary intake and the indoor environment on childhood asthma, we propose a panel study of children living in urban neighborhoods enriched with African-American and lower income participants. We have already shown that in the neighborhoods of the proposed study participants that in-home pollutant levels, including particulate matter (PM) and nitrogen dioxide (NO2), greatly exceed the outdoor levels and suburban indoor levels and that these in-home pollutants are independently associated with increased asthma morbidity. Furthermore, we have already demonstrated that the diet in this high-risk population is poor and is of a pattern that is inconsistent with dietary patterns that have been shown to protect against asthma. We plan to examine the effect of the poor "inner city" diet on susceptibility of asthmatic children to in-home pollutant (PM and NO2) exposure (Aim 1), and to identify barriers and enabling factors to implementing dietary and environmental modifications in inner city homes of children with asthma (Aim 2). To address these aims will plan to recruit 200 children with asthma, ages 5-12, in inner city Baltimore, each of whom will undergo 3 seven-day monitoring periods (at baseline, 3 months and 6 months) where they will undergo indoor air monitoring, dietary and respiratory assessments, nasal lavage, exhaled nitric oxide measurements, urine collection and blood draw for markers of inflammation and oxidative stress. Importantly, the aims in this application build upon the well-established infrastructure of a group of experienced investigators with diverse but highly integrated areas of expertise. This real-world field-based study will complement the findings from Projects 2 and 3 by demonstrating the clinical effect of diet on response to indoor pollutants, and by providing corroborative evidence of the oxidative stress and inflammatory pathways by which they may act. Projects 2 and 3 will similarly examine the effects of diet on response to pollutants, but in controlled settings using human subjects and animal.

哮喘是一种常见且复杂的疾病。在美国，哮喘带来的负担是巨大的 对幼儿、非裔美国人和其他弱势群体的影响尤为严重 在内城。这些最脆弱的人群往往居住在污染过度的环境中 水平，包括高水平的室内污染物和过敏原。此外，低收入人群的饮食、内 城市非裔美国人的营养状况明显不符合国家营养指南，并且具有以下模式： 可能使他们特别容易受到吸入污染物和过敏原的影响。为了解决 关于饮食摄入和室内环境对儿童哮喘的作用的关键问题，我们提出 对居住在非裔美国人和低收入城市社区的儿童进行的小组研究 参与者。我们已经表明，在拟议的研究参与者的社区中，在家中 颗粒物（PM）和二氧化氮（NO2）等污染物水平大大超过了标准 室外水平和郊区室内水平，并且这些室内污染物是独立相关的 随着哮喘发病率的增加。此外，我们已经证明，这种高风险饮食 人口贫困，其饮食模式与已证明的饮食模式不一致 预防哮喘。我们计划研究不良的“内城”饮食对易感性的影响 哮喘儿童在家中污染物（PM 和 NO2）暴露（目标 1），并确定障碍和 在内城区儿童家庭中实施饮食和环境改变的有利因素 患有哮喘（目标 2）。为了实现这些目标，我们计划招募 200 名 5 至 12 岁的哮喘儿童， 巴尔的摩市中心，每个人都将接受 3 个为期 7 天的监测期（基线、3 个月和 6 个月），他们将接受室内空气监测、饮食和呼吸评估、鼻腔评估 灌洗、呼出一氧化氮测量、尿液收集和抽血以检测炎症标志物 和氧化应激。重要的是，该应用程序的目标建立在完善的基础设施之上 由一群经验丰富的研究人员组成，他们具有不同但高度综合的专业领域。这个现实世界 实地研究将通过展示临床研究来补充项目 2 和 3 的发现 饮食对室内污染物反应的影响，并提供氧化的确凿证据 它们可能发挥作用的应激和炎症途径。项目 2 和 3 将类似地检查 饮食对污染物反应的影响，但在受控环境中使用人类受试者和动物。