Novel Optrode Devices for Neuroscientists: Packaging and Waveguide Solutions to M

面向神经科学家的新型光极器件：M 的封装和波导解决方案

• 批准号: 8058436
• 负责人: JOHN P SEYMOUR
• 金额: $ 17.56万
• 依托单位: NEURONEXUS TECHNOLOGIES
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-03-15 至 2013-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8058436
• 关键词: Animals; Automobile Driving; Behavior; Behavioral; Communities; Couples; Cues; Custom; Devices; Diffusion; Dimensions; Disease model; Excision; Face; Financial Support; Future; Hand; Ion Channel; Joints; Laboratories; Lesion; Light; Lighting; Measures; Methods; Modeling; Modification; Monitor; Morphologic artifacts; Mus; Neurons; Neurosciences; Neurosciences Research; Operative Surgical Procedures; Optics; Output; Pattern; Plague; Polymers; Population; Productivity; Protocols documentation; Research Personnel; Rodent; Science; Silicon Dioxide; Site; Solutions; Specificity; Surface Properties; System; Techniques; Technology; Tissues; Translating; United States National Institutes of Health; Work; base; cell type; cost; cost effective; cost effectiveness; density; design; improved; innovation; light intensity; meetings; neural circuit; novel; optical fiber; relating to nervous system; research study; response; tool

DESCRIPTION (provided by applicant): The objective of this application is to develop advanced optrode solutions for neuroscientists that fulfill the potential of optogenetic technology-achieving highly specific neural circuit control. Once developed, the neuroscientist's experimental options for optical stimulation will grow to two dimensions with no limits on the recording site placement. Our approach develops (i) practical, yet novel solutions for the packaging issues currently plaguing users, and (ii) custom waveguides capable of region-specific illumination with no electrical artifact, and is modularly integrated onto any existing NeuroNexus recording array. As an alternative to wafer- level integration, we have devised an approach that lowers cost by improving yield while increasing design options. This project will further optogenic techniques, which have shown excellent promise as tools that allow temporally precise, non-invasive control of activity in well- defined neuronal populations. This degree of control over neural firing allows specific monitoring of temporal activity patterns in the context of circuit dynamics, understanding changes due to plasticity, and responses to behavior and external cues, which is critically important for studying disease models as well. PUBLIC HEALTH RELEVANCE: The objective of this application is to develop advanced optrode solutions for neuroscientists that fulfill the potential of optogenetic technology-achieving highly specific neural circuit control. Once developed, the neuroscientist's experimental options for optical stimulation will grow to two dimensions with no limits on the recording site placement. Our approach develops (i) practical, yet novel solutions for the packaging issues currently plaguing users, and (ii) custom waveguides capable of region-specific illumination with no electrical artifact, and is modularly integrated onto any existing NeuroNexus recording array. As an alternative to wafer- level integration, we have devised an approach that lowers cost by improving yield while increasing design options. This project will further optogenic techniques, which have shown excellent promise as tools that allow temporally precise, non-invasive control of activity in well- defined neuronal populations. This degree of control over neural firing allows specific monitoring of temporal activity patterns in the context of circuit dynamics, understanding changes due to plasticity, and responses to behavior and external cues, which is critically important for studying disease models as well.

描述（由申请人提供）：本申请的目的是为神经科学家开发高级Optrode解决方案，以满足光遗传学方面的高度特异性神经电路控制的潜力。一旦开发，神经科学家的光刺激的实验选择将增长到两个维度，而记录位点放置则无限。我们的方法为当前困扰用户的包装问题开发了（i）实用但新颖的解决方案，以及（ii）能够具有特定于区域的照明的自定义波导，没有电气伪像，并且可以模块化地集成到任何现有的Neuronexus录制阵列中。作为晶圆级集成的替代方案，我们设计了一种方法，该方法通过提高产量同时提高设计选择来降低成本。该项目将进一步进一步的光源技术，这些技术表现出了极好的希望，作为允许在良好定义的神经元种群中进行时间精确的非侵入性控制的工具。这种对神经射击的控制程度允许在电路动态的背景下特定监测时间活动模式，理解由于可塑性而导致的变化以及对行为和外部线索的反应，这对于研究疾病模型至关重要。 公共卫生相关性：该应用程序的目的是为神经科学家开发高级Optrode解决方案，以满足光遗传学方面的高度特异性神经电路控制的潜力。一旦开发，神经科学家的光刺激的实验选择将增长到两个维度，而记录位点放置则无限。我们的方法为当前困扰用户的包装问题开发了（i）实用但新颖的解决方案，以及（ii）能够具有特定于区域的照明的自定义波导，没有电气伪像，并且可以模块化地集成到任何现有的Neuronexus录制阵列中。作为晶圆级集成的替代方案，我们设计了一种方法，该方法通过提高产量同时提高设计选择来降低成本。该项目将进一步进一步的光源技术，这些技术表现出了极好的希望，作为允许在良好定义的神经元种群中进行时间精确的非侵入性控制的工具。这种对神经射击的控制程度允许在电路动态的背景下特定监测时间活动模式，理解由于可塑性而导致的变化以及对行为和外部线索的反应，这对于研究疾病模型至关重要。