Genetic and Neural Complexity in Psychiatry

精神病学中的遗传和神经复杂性

• 批准号: 8089553
• 负责人: MARIA KARAYIORGOU
• 金额: --
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-15 至 2015-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8089553
• 关键词: Address; Animals; Brain Diseases; Cell model; Communication; Development; Developmental Cell Biology; Discipline; Early treatment; Future; Generations; Genetic; Goals; Mental disorders; Mutation; Neurobiology; Neurosciences; Patients; Prevention strategy; Psychiatry; Research; Series; Shapes; Technology; Time; Translations; design; gene function; meetings; mouse model; nonhuman primate; novel strategies; psychogenetics; public health relevance; relating to nervous system

DESCRIPTION (provided by applicant): Recent advances in the field of psychiatric genetics have brought about excitement and urgency to envision and design intelligently the next steps in order to inform the neurobiology of the psychiatric disorders and develop strategies for prevention, early intervention, or treatment. The primary goal of the meeting on the "Genetic and Neural Complexity in Psychiatry" is to facilitate a discussion on the future of research in Psychiatry as it is shaped by the recent advances in genetics and newly emerging concepts and approaches in neuroscience. This meeting will bring together experts and open a dialogue between geneticists and neuroscientists allowing direct translation and speedy application of recent findings. The first planned meeting in the proposed series of 3 bi-annual meetings, will focus on deep sequencing approaches, which will allow discovery of rare, highly penetrant mutations, as well as on approaches designed to understand their impact on gene function, including the generation of mouse models. It will also address emerging reprogramming technologies that allow development of cellular models from patients carrying specific rare mutations as well as the pros and cons of studying additional animal species with particular emphasis on non-human primates. Finally, it will highlight and discuss novel approaches to decipher circuitry and communication in the disease brain. PUBLIC HEALTH RELEVANCE: This meeting brings together pre-eminent experts in a range of disciplines, including genetics, neurobiology, cell and developmental biology, and psychiatry, to identify issues of importance, and set goals and standards for the critical advancement of the field of Psychiatry. The time is opportune, since recent advances in the field of psychiatric genetics call for careful planning of the next steps in order to inform the neurobiology of the psychiatric disorders and develop strategies for prevention, early intervention, or treatment.

描述（由申请人提供）：精神遗传学领域的最新进展引起了兴奋和紧迫感，以智能地设想和设计下一步，以便为精神疾病的神经生物学提供信息，并制定预防，早期干预或治疗的策略。关于“精神病学中遗传和神经复杂性”会议的主要目标是促进有关精神病学研究未来的讨论，因为它是由遗传学以及神经科学中新出现的概念和方法的最新进展所塑造的。这次会议将汇集专家，并在遗传学家和神经科学家之间进行对话，允许直接翻译和快速应用最近的发现。在拟议的三个两年一次会议系列中的第一次计划会议将集中在深层测序方法上，这将允许发现罕见的高度渗透突变，以及旨在了解其对基因功能的影响的方法，包括小鼠模型的产生。它还将解决新兴的重编程技术，这些技术允许从携带特定罕见突变的患者以及研究其他动物物种的利弊中开发细胞模型，并特别强调非人类灵长类动物。最后，它将强调并讨论疾病大脑中解密电路和通信的新颖方法。 公共卫生相关性：这次会议汇集了一系列学科的杰出专家，包括遗传学，神经生物学，细胞和发育生物学以及精神病学，以识别重要性问题，并为精神病领域的批判性进步设定目标和标准。现在是时候了，因为精神遗传学领域的最新进展要求仔细规划下一步，以便为精神疾病的神经生物学提供信息，并制定预防，早期干预或治疗的策略。