The Role of Ubiquitination in Methamphetamine Neurotoxicity (CDA)

泛素化在甲基苯丙胺神经毒性 (CDA) 中的作用

• 批准号: 8110226
• 负责人: Anna Moszczynska
• 金额: $ 24.9万
• 依托单位: WAYNE STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2013-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8110226
• 关键词: 26S proteasome; Accident and Emergency department; Affect; Animal Model; Antidotes; Autoreceptors; Binding; C-terminal; Cell Death; Cell membrane; Cell physiology; Characteristics; Cytosol; DNA; Data; Development; Dopamine; Dopamine D2 Receptor; Dose; Drug toxicity; Electron Transport; Electrons; Energy Metabolism; Enzymes; Exocytosis; Filament; Goals; Impaired cognition; Impairment; Intervention; Knowledge; Lead; Learning; Life; Link; Lipids; Mediating; Membrane; Mentors; Methamphetamine; Methamphetamine dependence; Mitochondria; Molecular; Nerve Degeneration; Neurodegenerative Disorders; Neurons; Overdose; Oxidative Stress; Pathway interactions; Pharmaceutical Preparations; Pharmacologic Substance; Phase; Physicians; Play; Process; Production; Property; Proteins; Reactive Oxygen Species; Receptor Signaling; Recycling; Regulation; Research; Research Personnel; Role; Signal Transduction; Site; Solid; Synaptic Vesicles; System; Techniques; Testing; Toxic Actions; Toxic effect; Toxin; Transcriptional Regulation; Transmembrane Transport; Travel; Ubiquitin; Ubiquitination; Up-Regulation; Vesicle; Work; base; career; dopamine transporter; dopaminergic neuron; experience; feeding; genetic regulatory protein; in vivo; methamphetamine abuse; mitochondrial dysfunction; multicatalytic endopeptidase complex; neuroprotection; neurotoxicity; neurotransmission; novel; overexpression; oxidation; parkin gene/protein; prevent; programs; protein misfolding; protein protein interaction; receptor; receptor expression; receptor function; restoration; skills; stressor; trafficking; ubiquitin-protein ligase; uptake; vesicular monoamine transporter; vesicular monoamine transporter 2