CLINICAL AND TRANSLATIONAL RESEARCH METHODS CORE

临床和转化研究方法核心

基本信息

批准号：
8122163
负责人：
Richard F MACKO
金额：
$ 14.15万
依托单位：
UNIVERSITY OF MARYLAND BALTIMORE
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/8122163
关键词：
Adherence Aerobic Age Aging Baltimore Basic Science Behavioral Biological Biological Adaptation Body Composition Cardiovascular Diseases Cardiovascular system Characteristics Chronic Chronic Disease Clinical Clinical Data Clinical Sciences Collaborations Communities Comorbidity Consultations Databases Dependence Development Diabetes Mellitus Disability phenotype Disabled Persons Disease Elderly Epidemiologic Studies Epidemiology Evaluation Evaluation Research Event Exercise Exercise stress test Frequencies Health Health Policy Health Promotion High Prevalence Hip Fractures Hip region structure Home environment Hyperlipidemia Hypertension Individual Intention Intervention Investigation Knowledge Laboratories Leadership Life Style Mediating Medical Methodology Methods Mission Modality Modeling Modification Natural History Outcome Participant Patients Physiological Policy Research Population Process Quality of life Recommendation Recovery Recurrence Rehabilitation Research Rehabilitation therapy Research Research Design Research Infrastructure Research Methodology Research Personnel Resources Risk Risk Factors Services Stroke Time Training Translational Research Translations Universities adjudicate base community living community setting conditioning design disability functional disability functional outcomes improved loss of function motor learning neuromuscular neuromuscular function new technology older patient outcome forecast population based programs quality assurance ranpirnase rehabilitation strategy social stroke rehabilitation therapy development treatment adherence treatment strategy

项目摘要

The mission of RC-1 is to design, implement, and evaluate clinical and translational research in exercise rehabilitation and recovery in older patients with stroke, hip fracture, and other medical conditions associated with functional limitations in aging. Reorganization of UM-OAIC from a project to a Core based Center led to the proposed core, which provides access and leadership to Pepper and other university resources to conduct translational rehabilitation research in functionally limited older people. Two levels of translation: bench to clinical laboratory; and clinical laboratory to community, are facilitated. Core directors were chosen for their leadership in common and costly disabling conditions in older people, stroke and hip fracture. Our stroke rehabilitation program investigated physiological and functional efficacy of motor learning-based exercise rehabilitation interventions via relatively small intervention development studies in the UM-OAIC that included examination of biological mechanisms underlying functional impairment. The Baltimore Hip Studies (BHS) have been ongoing for >20 years and emphasized larger epidemiological studies. In these investigations, we have examined physiological and functional sequelae of hip fracture in community settings, and exercise interventions implemented in the home. The intention for the proposed UM-OAIC is to apply constructive methods and knowledge from each disabling condition, to the other condition so that stroke research can be taken into community settings, and hip fracture research can be pursued in the clinical and basic science laboratories, including a focus on exercise-mediated biological adaptations. Increasing collaborations represented by dual core leadership provide a translational research model that focuses on the following aims: 1)To facilitate design and conduct of research mechanisms underlying functional limitations associated with stroke, hip fracture and other chronic diseases in older people to determine the disability phenotype across a spectrum of neuromuscular, cardiovascular, functional and behavioral domains. 2)To facilitate evaluation of the multi-faceted processes by which older persons who develop disabling medical diseases such as stroke or hip fracture decline functionally, and either recover with rehabilitation or develop comorbid medical conditions that worsen their prognosis. 3)To facilitate development and implementation of disease and disability specific exercise and motor learning interventions, including application of new technologies, adherence strategies and treatment fidelity to optimize clinical and functional outcomes.4)To utilize infrastructure of the Pepper to facilitate testing of exercise interventions at the community level, and help investigators study the factors that could impede or facilitate the broader dissemination of health and function promoting exercise interventions for aging populations with functional limitations.

RC-1的任务是设计，实施和评估锻炼中的临床和翻译研究老年患者中风，髋部骨折和其他医疗状况的康复和康复衰老的功能限制。 UM-OAIC从项目重组到基于核心的中心导致拟议的核心为胡椒和其他大学资源提供访问和领导才能在功能上有限的老年人中进行翻译康复研究。翻译两个级别：长凳到临床实验室；和社区的临床实验室得到了促进。选择了核心主管对于他们在老年人的共同和昂贵的残疾条件下的领导才能，中风和髋部骨折。我们的中风康复计划调查了基于运动学习的生理和功能疗效通过在UM-OAIC中相对较小的干预发展研究进行锻炼康复干预措施其中包括检查功能障碍的生物学机制。巴尔的摩臀部研究（BHS）已经持续了20年，并强调了更大的流行病学研究。在这些调查，我们检查了社区中髋部骨折的生理和功能后遗症设置和在家中实施的锻炼干预措施。提议的UM-OAIC的意图是将每个禁用条件的建设性方法和知识应用于另一种条件，以便可以将中风研究用于社区环境，可以在临床和基础科学实验室，包括专注于运动介导的生物学适应。双重核心领导代表的越来越多的合作提供了一种转化研究模型专注于以下目的：1）促进设计和进行研究机制的设计与中风，髋部骨折和其他老年人相关的功能限制确定跨神经肌肉，心血管，功能和功能和行为领域。 2）促进评估多面过程发展残疾的医疗疾病，例如中风或髋部骨折的功能下降，然后恢复随着康复或发展合并症，预后恶化。 3）促进疾病的发展和实施特定的运动和运动干预措施，包括应用新技术，依从性策略和治疗保真度以优化临床和功能结果。4）利用胡椒的基础设施来促进运动干预措施的测试社区层面，并帮助调查人员研究可能阻碍或促进更广泛的因素传播健康和功能，以促进具有功能性衰老人群的运动干预措施限制。