Immersion in Drug Abuse

沉浸在药物滥用中

• 批准号: 8056794
• 负责人: ESTELLE B. GAUDA
• 金额: $ 33.57万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-01 至 2014-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8056794
• 关键词: Adolescence; Adolescent Medicine; Adverse effects; Age; Behavior; Biology; Birth; Brain; Development; Doctor of Medicine; Doctor of Philosophy; Drug Addiction; Drug Metabolic Detoxication; Drug Tolerance; Drug abuse; Drug usage; Education; Family; Fetus; Goals; Grant; Human; Illicit Drugs; Immersion Investigative Technique; Intervention; Learning; Mediating; Medical Students; Medical center; Mission; NIH Program Announcements; National Institute of Drug Abuse; Newborn Infant; Opiate Addiction; Opiates; Pharmaceutical Preparations; Physicians; Pregnancy; Pregnant Women; Prevention strategy; Reporting; Research; Research Personnel; Research Training; Risk-Taking; Scientist; Staging; Students; Surveys; Training; Training Programs; United States; Universities; Woman; addiction; alternative treatment; base; career; design; experience; fetal; nervous system development; next generation; novel; pediatric department; pregnant; programs; psychosocial; reproductive; response

DESCRIPTION (provided by applicant): A NIDA conducted national survey reported that 5.5% of 4 million women who gave birth in the United States in 1992 used illegal drugs while they were pregnant. In addition to the psychosocial ramifications, illicit drug use also has adverse effects on the development of the nervous system in the fetus and newborn and increases the possibilities of risk taking behavior in adolescence. Little is known about the biology of addiction to illicit drugs in the developing fetus and newborn and few investigators specialize in this important field. In response to the program announcement (PAR-04-054), Research Education Grants in Drug Abuse and Addiction, the overall goal of this proposal is to bring together the scientific and educational expertise in drug abuse research at Johns Hopkins and Morgan State University to create a novel educational/research training program with the mission of training researchers in the basic biology and psychosocial aspects of illicit drug use in the young woman entering reproductive age, the pregnant woman, and her fetus and newborn. Under the co-directorship of Estelle Gauda, M.D., a physician-scientist at Johns Hopkins, and Gabrielle McLemore, Ph.D., a educator-scientist at Morgan State University, we have created a partnership between investigators from the Center for Addiction and Pregnancy at Johns Hopkins Bayview Medical Center, the Kennedy Krieger Family Center, the Department of Pediatrics and Adolescent Medicine at Johns Hopkins University, and Morgan State University to accomplish this goal through 2 educational programs. The Summer Immersion in Drug Abuse Research Program (SIDARP) is a 10 week educational-research/training experience which will target doctoral students, medical students, and physicians at an early stage of their professional careers. The Drug Abuse Research Training (DART) Program is a long-term (2-3 years) research experience designed to target pre and postdoctoral students and clinician-scientists to be the next generation of leaders in the field of drug addiction and abuse research and education. The training program will use a competency based learning strategy to maximize learning. Emphasis will be given to having educational and research opportunities that will include basic mechanisms mediating drug dependence and tolerance in the fetus and newborn, effects of opiate exposure on human fetal behavior and newborn brain development, alternative treatment and detoxification strategies for opiate addiction during pregnancy and in the newborn, and drug abuse intervention and prevention strategies in women of reproductive age.

描述（由申请人提供）：NIDA进行的全国调查报告说，在1992年在美国出生的400万妇女中有5.5％在怀孕期间使用了非法毒品。除了心理社会的后果外，非法药物使用还会对胎儿和新生儿的神经系统的发展产生不利影响，并增加了青春期冒险行为的可能性。关于发展中胎儿和新生儿中非法药物成瘾的生物学知之甚少，很少有研究人员专门研究这一重要领域。 In response to the program announcement (PAR-04-054), Research Education Grants in Drug Abuse and Addiction, the overall goal of this proposal is to bring together the scientific and educational expertise in drug abuse research at Johns Hopkins and Morgan State University to create a novel educational/research training program with the mission of training researchers in the basic biology and psychosocial aspects of illicit drug use in the young woman entering reproductive age, the pregnant woman, and her fetus and新生儿。在约翰·霍普金斯（Johns Hopkins）的医师科学家Estelle Gauda（M.D.）和摩根州立大学（Morgan State State University）的教育工作者 - 科学家Gabrielle McLemore博士学位的埃斯特尔·高田（Estelle Gauda）的共同指导下，我们已经建立约翰·霍普金斯大学（Johns Hopkins University）和摩根州立大学（Morgan State University）通过2个教育计划来实现这一目标。夏季浸入药物滥用研究计划（SIDARP）是为期10周的教育研究/培训经验，它将在其职业职业的早期阶段以博士生，医学生和医生为目标。药物滥用研究培训（DART）计划是一项长期（2 - 3年）的研究经验，旨在针对博士后和博士后学生和临床医生 - 科学家成为吸毒和虐待研究和教育领域的下一代领导者。培训计划将使用基于能力的学习策略来最大化学习。将重点放在拥有教育和研究机会上，其中包括介导药物依赖和耐受性的基本机制，阿片类药物对人类胎儿行为的影响以及新生儿大脑发育的影响，替代性治疗以及阿片化的替代性治疗策略以及在怀孕期间以及新生儿滥用和预防策略在妊娠期间成瘾，以及对生殖年龄的妇女的滥用和预防策略。

项目成果

Narp knockout mice show normal reactivity to novelty but attenuated recovery from neophobia.

Narp 基因敲除小鼠对新奇事物表现出正常的反应性，但从恐惧症中恢复的能力减弱。

• DOI: 10.1016/j.bbr.2013.10.001
• 发表时间: 2013
• 期刊: Behavioural brain research
• 影响因子: 2.7
• 作者: Blouin,AshleyM;Lee,JongahJ;Tao,Bo;Smith,DaniR;Johnson,AlexanderW;Baraban,JayM;Reti,IrvingM
• 通讯作者: Reti,IrvingM

Spinal cord protein interacting with C kinase 1 is required for the maintenance of complete Freund's adjuvant-induced inflammatory pain but not for incision-induced post-operative pain.

• DOI: 10.1016/j.pain.2010.07.017
• 发表时间: 2010-10
• 期刊: Pain
• 影响因子: 7.4
• 作者: Atianjoh FE;Yaster M;Zhao X;Takamiya K;Xia J;Gauda EB;Huganir RL;Tao YX
• 通讯作者: Tao YX

Comparison of cigarette smoking knowledge, attitudes, and practices among staff in perinatal and other substance abuse treatment settings.

• DOI: 10.1097/adm.0000000000000068
• 发表时间: 2014-09
• 期刊: Journal of addiction medicine
• 影响因子: 5.5
• 作者: Miller-Thomas T;Leoutsakos JM;Terplan M;Brigham EP;Chisolm MS
• 通讯作者: Chisolm MS

Opioids and clonidine modulate cytokine production and opioid receptor expression in neonatal immune cells.

• DOI: 10.1038/jp.2012.124
• 发表时间: 2013-05
• 期刊: JOURNAL OF PERINATOLOGY
• 影响因子: 2.9
• 作者: Chavez-Valdez, R.;Kovell, L.;Ahlawat, R.;McLemore, G. L.;Wills-Karp, M.;Gauda, E. B.
• 通讯作者: Gauda, E. B.