Cancer Nanotechnology in Imaging and Radiotherapy

癌症纳米技术在成像和放射治疗中的应用

基本信息

批准号：
8133003
负责人：
GAYLE E. WOLOSCHAK
金额：
$ 46.73万
依托单位：
NORTHWESTERN UNIVERSITY AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-09-25 至 2014-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8133003
关键词：
Academia Address Administrator Advisory Committees Angiogenesis Inhibitors Animal Model Animals Applications Grants Area Basic Science Binding Biochemical Biological Products Biology Blood capillaries Brain Neoplasms CCNE1 gene Cancer Center Cancer Detection Carbon Nanotubes Cell model Cells Characteristics Chemicals Chemistry Chicago Clinical Clinical Oncology Clinical Research Clinical Trials Collaborations Complex Conceptions Conduct Clinical Trials Contrast Media Coupled Dendrimers Detection Development Devices Discipline Education Engineering Enrollment Environment Evaluation Exhibits Exposure to Eye Faculty Familiarity Feedback Foundations Fruit Funding Future Gadolinium Generations Gold Heating Human Human body Hydrogels Image Imaging Device Institution Integrins Ions Knowledge Laboratories Language Lesion Light Link Location Magnetic Resonance Imaging Magnetism Malignant Neoplasms Malignant neoplasm of brain Malignant neoplasm of prostate Manuscripts Master of Science Medical Metastatic Lesion Metastatic Neoplasm to the Bone Methodology Methods Michigan Mission Missouri Molecular Monitor Nanotechnology Nature Normal tissue morphology Outpatients Pathway interactions Patients Performance Pharmaceutical Preparations Pharmacology Phase Photochemotherapy Physics Physiological Play Positioning Attribute Preclinical Testing Private Sector Process Property Prostatic Neoplasms Publications Publishing Quantum Dots Radiation Oncologist Radiation Oncology Radiation therapy Radiation-Sensitizing Agents Radiology Specialty Research Research Personnel Research Project Grants Research Training Residencies Robert H Lurie Comprehensive Cancer Center of Northwestern University Roentgen Rays Role Roswell Park Cancer Institute Safety Scientist Signal Transduction Site Specificity Spottings Staging Students Technology Temperature Testing Therapeutic Therapeutic Agents Training Training Program for Cancer Prevention and Control Scientists (R25)Training Programs Translating Translations Tumor Biology Ultrasonography Universities Virginia Washington Writing abstracting angiogenesis base bench to bedside cancer cell cancer diagnosis cancer imaging cancer therapy capillary career development cellular oncology chemotherapy clinical application clinical practice design direct application experience gadolinium oxide grasp image guided therapy imaging modality in vivo iron oxide magnetic field medical specialties meetings melting member molecular imaging multidisciplinary nano nanodevice nanomaterials nanoparticle nanoparticulate nanoscale nanosized nanovector neoplastic cell neovascular novel oncology service optical imaging particle physical property pre-clinical preclinical study programs radiologist response skills success therapeutic target tool tumor

项目摘要

DESCRIPTION (provided by applicant): This is the second revision of a proposal to establish an R25T cancer education and career development program, Cancer Nanotechnology in Imaging and Radiotherapy. Radiology and radiation oncology are clinical specialties that are heavily used for cancer diagnosis and treatment and that are likely to be revolutionized by advances in nanotechnology. For the fruits of nanotechnology research to benefit patients who are receiving radiology or radiation oncology services, there must be close collaboration between physical scientists, tumor biologists, and clinicians. The most important role of the clinician is to design and conduct clinical trials that assess the safety and efficacy of a newly developed nanomaterial. Fulfillment of this role requires not only clinical trials expertise, but also familiarity with the physical and chemical characteristics of the nanomaterial being tested and with the results of preclinical studies. Clinician input can also be critical in the conception of a nanotechnology study, in obtaining funding for such a study, in preclinical studies, especially those that involve animal imaging, and in dealing with regulatory agencies. To participate fully in the entire bench ? bedside process, radiologists and radiation oncologists must have a basic understanding of nanotechnology concepts and methodologies, a familiarity with nanotechology safety and regulatory issues, and an excellent grasp of the principles and practices of tumor biology. Furthermore, they need to be well-versed in the design and conduct of clinical trials, be familiar with small animal imaging, and be able to write research grants, IND applications, and manuscripts. There are presently no formal mechanisms by which clinicians in these specialties can acquire these skills and knowledge. To address these needs, Northwestern University, in conjunction with the University of Chicago, is proposing this education and career development program. The program will consist of formal coursework, supplementary educational experiences, participation in a laboratory-based cancer nanotechnology project, and participation in a cancer-related radiology or radiation oncology clinical study. Trainees will have the option of completing the requirements for a Master of Science in Clinical Investigation (MSCI). Program management will consist of the program director, Dr. Gayle Woloschak, four additional faculty members who will oversee various trainee activities, an advisory committee, and a program administrator. While the program is targeted to MDs who have just completed a residency in radiology or radiation oncology, it will also be open to practicing clinicians in these specialties. The program will operate under the auspices of the Robert H. Lurie Comprehensive Cancer Center of Northwestern University, with strong support from the Depts. of Radiology and of Radiation Oncology at Northwestern University and from the Depts. of Radiology and of Radiation & Cellular Oncology at the University of Chicago. The program will have strong links to Northwestern's Center for Cancer Nanotechnology Excellence.

描述（由申请人提供）：这是建立R25T癌症教育和职业发展计划，成像和放疗中癌症纳米技术的提案的第二次修订。放射学和放射肿瘤学是临床专业，大量用于癌症诊断和治疗，并且很可能会因纳米技术的进步而彻底改变。为了使纳米技术研究的果实使接受放射学或放射肿瘤学服务的患者有益，必须在物理科学家，肿瘤生物学家和临床医生之间进行密切合作。临床医生最重要的作用是设计和进行临床试验，以评估新开发的纳米材料的安全性和功效。履行此角色不仅需要临床试验专业知识，而且还需要熟悉正在测试的纳米材料的物理和化学特征以及临床前研究的结果。临床医生的输入在纳米技术研究的概念中也可能至关重要，在临床前研究中，尤其是涉及动物成像的人以及与监管机构打交道的临床前研究中，在获得此类研究的资金时也可能至关重要。要充分参加整个替补席？床头过程，放射科医生和放射肿瘤学家必须对纳米技术概念和方法论，熟悉纳米技术的安全性和调节性问题以及对肿瘤生物学原理和实践的极好理解。此外，他们需要在临床试验的设计和行为上进行良好的介绍，熟悉小动物成像，并能够撰写研究补助金，IND应用和手稿。目前，这些专业中的临床医生无法获得这些技能和知识。为了满足这些需求，西北大学与芝加哥大学一起提出了这项教育和职业发展计划。该计划将包括正式的课程，补充教育经验，参与基于实验室的癌症纳米技术项目以及与癌症相关的放射学或放射肿瘤学临床研究的参与。学员将可以选择完成临床研究硕士学位（MSCI）的要求。计划管理将由计划主任盖尔·沃洛沙克（Gayle Woloschak）博士组成，另外四名教职员工将监督各种学员活动，咨询委员会和计划管理员。尽管该计划针对刚刚完成放射学或放射肿瘤学居住的MDS，但也将向这些专业的临床医生开放。该计划将在西北大学罗伯特·H·卢里综合癌症中心的主持下运作，并得到部门的大力支持。西北大学的放射学和放射肿瘤学的研究。芝加哥大学的放射学和辐射和细胞肿瘤学的研究。该计划将与西北癌症纳米技术中心卓越中心有牢固的联系。