Cincinnati Neuro-Oncology Research Core

辛辛那提神经肿瘤学研究核心

基本信息

批准号：
7944174
负责人：
NANCY RATNER
金额：
$ 71万
依托单位：
CINCINNATI CHILDRENS HOSP MED CTR
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-09-30 至 2012-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7944174
关键词：
Accounting Adult Affect Animal Model Area Basic Science Biological Models Biology Bone Marrow Transplantation Brain Brain Neoplasms Caring Cell model Central Nervous System Neoplasms Child Childhood Childhood Brain Neoplasm Clinic Clinical Clinical Oncology Clinical Trials Community Clinical Oncology Program Development Developmental Biology Diagnostic radiologic examination Environment Ependymoma Erinaceidae Faculty Focus Groups Funding Generations Genome Glioma Goals Hereditary Malignant Neoplasm Home environment Individual Informatics Investigational Therapies Knowledge Lead Malignant Childhood Neoplasm Malignant Neoplasms Metabolism Modeling Molecular Nervous Mouse Nervous System Neoplasms Nervous system structure Neurilemmoma Neuroepithelial, Perineurial, and Schwann Cell Neoplasm Operative Surgical Procedures Outcome Pathway interactions Patients Pediatric Hospitals Phase Phase I Clinical Trials Population Process Psychology Radiation Oncology Recruitment Activity Regulation Research Research Personnel Role Scientist Signal Pathway Spinal Cord Stem cells Syndrome Therapeutic Tumor Suppressor Proteins Universities Vision Work base biomedical informatics carcinogenesis clinical care improved innovation insight interest leukemia medulloblastoma member meningioma mouse model neoplasm type nerve stem cell neuro-oncology notch protein novel outcome forecast patient population pre-clinical programs relating to nervous system stem success

项目摘要

DESCRIPTION (Provided by the applicant): Tumors of the nervous system are the second most common types of neoplasm in the pediatric population. In contrast to the most common cancer (leukemia), strides have been made in improving outcomes for some nervous system tumors but many remain difficult or impossible to treat effectively. There is opportunity to dramatically improve outcome for nervous system cancer in children through development of new therapies. It is our hypothesis that interactive programs based in developmental biology studying individual nervous system tumor types will identify critical differences and similarities in molecular processes and extend the applicability of new therapies. Animal models and neural stem/progenitor cell models systems are now being used to study nervous system cancers and for preclinical development of novel therapies for nervous system tumors. Whole genome approaches are adding insight into developmental regulation and carcinogenesis. The goal of this proposal is to contribute to development of a multi-disciplinary, world-class Neuro-Oncology focus group within the Cincinnati Children's Hospital aimed at attacking the problem of neural tumors. Taking advantage of our institutional strengths in developmental biology and informatics, this will be accomplished by recruitment of 2 new Tenure Track faculty members. One is a developmental biologist with interest in the hippo signaling pathway and the other a neural tumor focused bioinformatician.

描述（由申请人提供）：神经系统的肿瘤是小儿种群中第二常见的肿瘤类型。与最常见的癌症（白血病）相反，在改善某些神经系统肿瘤的预后方面已经取得了长足的进步，但许多人仍然难以有效治疗。通过开发新疗法，有机会大大改善儿童神经系统癌的预后。我们的假设是，研究个体神经系统肿瘤类型的发展生物学的互动程序将确定分子过程中的关键差异和相似性，并扩展新疗法的适用性。动物模型和神经干/祖细胞模型系统现在用于研究神经系统癌症和神经系统新疗法的临床前开发肿瘤。整个基因组方法正在增加对发育调节和致癌作用的见解。该提案的目的是为辛辛那提儿童医院内的多学科，世界一流的神经肿瘤焦点小组的发展做出贡献，旨在攻击神经肿瘤的问题。利用我们在发展生物学和信息学方面的机构优势，这将通过招募2位新的终身教师招募来实现。一种是对河马信号通路有兴趣的发育生物学家，另一个是以神经肿瘤为焦点的生物信息学家。