A Partnership Initiative for HIV Prevention Trials

艾滋病毒预防试验合作倡议

• 批准号: 8084115
• 负责人: Kathleen M MacQueen
• 金额: $ 49.26万
• 依托单位: FAMILY HEALTH INTERNATIONAL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-11 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8084115
• 关键词: AIDS prevention; AIDS/HIV problem; Address; African American; Age; Attitude; Behavior; Collaborations; Communities; Community Surveys; Creativeness; Data Collection; Discrimination; Educational Curriculum; Ensure; Ethnography; Evaluation; Focus Groups; Fostering; Future; Group Affiliation; HIV prevention trial; Interview; Maps; Measures; Modeling; Participant; Policies; Population; Prevention program; Problem Solving; Process; Prophylactic treatment; Research; Research Design; Research Methodology; Research Personnel; Respondent; Risk; Sampling; Structure; Surveys; Technology; Trust; United States; Vaccines; community based participatory research; effective intervention; experience; health disparity; improved; literacy; microbicide; programs; public health relevance; success; theories

DESCRIPTION (provided by applicant): The proposed research addresses a critical question for the future success of vaccine, microbicide, pre-exposure prophylaxis and other emerging HIV prevention technologies in the United States: How can we ensure that the community support and program capacity to evaluate and deliver new HIV prevention technologies are available where they are most needed? The research setting (Durham, NC) provides an ideal context to conduct research to address this question. The 5-year study will evaluate a systematic partnership-building approach for HIV prevention trial planning and implementation. The research aims are three-fold. AIM 1 is to implement and conduct a process evaluation of a systematic community-based participatory research model to build support for new HIV prevention technologies in the African American community. This is accomplished through use of a conceptual framework that (1) integrates research with policy, community, behavior, and programs; (2) builds on community-based participatory research principles; (3) uses ethnography to generate empirical evidence to inform research design and provide a bridge between local residents, the research team, and other stakeholder groups; and (4) draws on group theory to refine the structure of stakeholder involvement and foster inclusiveness, creativity and active problem-solving. AIM 2 is to describe the communities and group affiliations that exist among young (ages 18-30) at-risk African Americans, and measure the relationship among experiences of discrimination, levels of trust, and support for new HIV prevention technologies in this population. AIM 3 is to identify priorities for evaluating and implementing new HIV prevention technologies in the African American community. Research methods include participant observation, ethnographic mapping, focus groups, semi-structured interviews, and quantitative surveys. An HIV prevention technologies research literacy curriculum will be developed, implemented and evaluated; the evaluation will include an assessment of community attitudes toward research on specific HIV prevention technologies. Support for and feasibility of collaboration in conducting local research on new HIV prevention technologies will assessed with multiple stakeholder groups including researchers. Across all years a two-way process evaluation of the evolving community partnership will be undertaken. Sampling strategies include respondent-driven sampling for a community survey of young at-risk African Americans in Years 2 and 3; purposive sampling will be used for all other data collection activities. The results of all data collection activities will be presented to community partners and guidance solicited for next steps in evaluating and delivering new HIV prevention technologies. PUBLIC HEALTH RELEVANCE: African Americans experience significant health disparities and this is especially evident with regard to HIV/AIDS in the U.S. South. Improving the capacity for HIV prevention trials in partnership with African American communities will lay the groundwork for moving effective interventions into successful prevention programs.

描述（由申请人提供）：拟议的研究解决了美国未来成功的关键问题，在美国的未来成功，暴露前预防和其他新出现的HIV预防技术：我们如何确保社区支持和计划能力和计划的能力，以评估和提供新的HIV预防技术？研究环境（北卡罗来纳州达勒姆）提供了一个理想的背景来进行研究以解决这个问题。这项为期5年的研究将评估一种系统性的伙伴关系方法，用于预防艾滋病毒试验计划和实施。研究目的是三倍。 AIM 1是对系统的基于社区的参与研究模型的过程评估，以建立对非裔美国人社区中新的HIV预防技术的支持。这是通过使用概念框架来实现的，该概念框架（1）将研究与政策，社区，行为和计划集成； （2）基于社区的参与研究原则； （3）使用民族志来生成经验证据，以告知研究设计并提供当地居民，研究小组和其他利益相关者群体之间的桥梁； （4）借鉴群体理论，以完善利益相关者参与和培养包容性，创造力和积极解决问题的结构。目的2是描述年轻人（18-30岁）处于危险的非洲裔美国人之间存在的社区和群体隶属关系，并衡量歧视，信任水平以及对该人群中新的HIV预防技术的支持之间的关系。 AIM 3是确定在非裔美国人社区评估和实施新的HIV预防技术的优先事项。研究方法包括参与者观察，人种学映射，焦点小组，半结构化访谈和定量调查。将开发，实施和评估HIV预防技术研究素养课程；评估将包括对社区对特定艾滋病毒预防技术研究的态度的评估。对新艾滋病毒预防技术进行本地研究的协作支持和可行性将与包括研究人员在内的多个利益相关者群体进行评估。在所有年份中，将进行对不断发展的社区伙伴关系的双向过程评估。抽样策略包括对受访者驱动的抽样，以对2年级和3年级的年轻处于年轻的非洲裔美国人进行社区调查；目的抽样将用于所有其他数据收集活动。所有数据收集活动的结果将介绍给社区合作伙伴，并为评估和提供新的HIV预防技术的下一步征求指导。 公共卫生相关性：非洲裔美国人经历了重大的健康差异，这对于美国南部的艾滋病毒/艾滋病尤为明显。与非裔美国人社区合作提高预防艾滋病毒预防试验的能力将为有效的干预措施迈向成功的预防计划。